Joseph P. Hanig
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View article: Assessing the developmental effects of fentanyl and impacts on lipidomic profiling using neural stem cell models
Assessing the developmental effects of fentanyl and impacts on lipidomic profiling using neural stem cell models Open
Fentanyl is a potent and short-acting opioid that is often given to pediatric patients during surgery to relieve pain and as an adjunct to anesthesia. Its effects on the developing brain are yet to be determined. In the present study, comm…
View article: Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models Open
Safety concerns about general anesthetics (GA), such as desflurane (a commonly used gaseous anesthetic agent), arose from studies documenting neural cell death and behavioral changes after early-life exposure to anesthetics and compounds w…
View article: The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses
The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses Open
Introduction In 2015, the FDA released a Drug Safety Communication regarding a possible link between opioid exposure during early pregnancy and an increased risk of fetal neural tube defects (NTDs). At the time, the indications for opioid …
View article: Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing
Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing Open
Neurotoxicity assessments are generally performed using laboratory animals. However, as in vitro neurotoxicity models are continuously refined to reach adequate predicative concordance with in vivo responses, they are increasingly used for…
View article: Quantitative Neurotoxicology: An Assessment of the Neurotoxic Profile of Kainic Acid in Sprague Dawley Rats
Quantitative Neurotoxicology: An Assessment of the Neurotoxic Profile of Kainic Acid in Sprague Dawley Rats Open
This study consisted of a qualitative and quantitative assessment of neuropathological changes in kainic acid (KA)–treated adult male rats. Rats were administered a single 10 mg/kg intraperitoneal injection of KA or the same volume of sali…
View article: Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism
Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism Open
View article: Microglial activation and responses to vasculature that result from an acute LPS exposure
Microglial activation and responses to vasculature that result from an acute LPS exposure Open
View article: Effects of the Na-K ATPase blocker digoxin on microglia structure and function in real time in the mouse retina.
Effects of the Na-K ATPase blocker digoxin on microglia structure and function in real time in the mouse retina. Open
View article: Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats
Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats Open
This work extends the understanding of how toxic exposures to amphetamine (AMPH) adversely affect the immune system and lead to tissue damage. Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia.…
View article: Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease
Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease Open
View article: Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study Open
Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, an…
View article: Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine
Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine Open
Our previous studies have raised the possibility that altered blood glucose levels may influence and/or be predictive of methamphetamine ( METH ) neurotoxicity. This study evaluated the effects of exogenous glucose and corticosterone ( COR…
View article: Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair? Open
View article: Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward
Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward Open
Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking. There is a need for more sensitive and specific biomarkers of neurotoxicity that can help diagnose and pr…
View article: Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood
Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood Open
Methods were developed to evaluate the stability of rat whole blood expression obtained from RNA sequencing (RNA-seq) and assess changes in whole blood transcriptome profiles in experiments replicated over time. Expression was measured in …
View article: Quantitative Assessment of MRI<i>T</i><sub>2</sub>Response to Kainic Acid Neurotoxicity in Rats<i>in vivo</i>
Quantitative Assessment of MRI<i>T</i><sub>2</sub>Response to Kainic Acid Neurotoxicity in Rats<i>in vivo</i> Open
The aim of this study was to assess quantitative changes in T2 relaxation using magnetic resonance imaging approaches in rats exposed to kainic acid to assess the utility of such endpoints as biomarkers of neurotoxicity. Quantitative T2 ma…