Joseph Saad
YOU?
Author Swipe
View article: Predictors of response and rational combinations for the novel <scp>MCL</scp> ‐1 inhibitor <scp>MIK665</scp> in acute myeloid leukemia
Predictors of response and rational combinations for the novel <span>MCL</span> ‐1 inhibitor <span>MIK665</span> in acute myeloid leukemia Open
Despite promising anti‐leukemic activity of MCL‐1 inhibitors in preclinical studies of acute myeloid leukemia (AML), clinical progress has been hindered by limited knowledge of target patient subgroups. To stratify patients for MCL‐1 inhib…
View article: NAMPT INHIBITION SELECTIVELY TARGETS MDS MYELOBLASTS IN HIGH-RISK MDS WITH MONOSOMY 7 OR DEL(7Q)
NAMPT INHIBITION SELECTIVELY TARGETS MDS MYELOBLASTS IN HIGH-RISK MDS WITH MONOSOMY 7 OR DEL(7Q) Open
Monosomy 7 and deletion of the q arm of chromosome 7 (-7/-7q) are high-risk markers in myelodysplastic syndromes (MDS). We previously showed that blasts with -7/-7q from patients with acute myeloid leukemia (AML) are exceptionally sensitiv…
View article: Network-Based Stratification Refines Stratification of Intermediate-Risk Acute Myeloid Leukemia Samples
Network-Based Stratification Refines Stratification of Intermediate-Risk Acute Myeloid Leukemia Samples Open
The European LeukemiaNet (ELN) risk stratification of acute myeloid leukemia (AML) uses genetic and molecular markers to categorize patients. However, disease heterogeneity, particularly in the intermediate-risk group, complicates stratifi…
View article: DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes
DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes Open
View article: Knee Pain After Jumping
Knee Pain After Jumping Open
View article: Predictors of Response and Rational Combinations for the Novel MCL-1 Inhibitor MIK665 in Acute Myeloid Leukemia
Predictors of Response and Rational Combinations for the Novel MCL-1 Inhibitor MIK665 in Acute Myeloid Leukemia Open
Despite promising anti-leukemic activity of MCL-1 inhibitors in preclinical studies of acute myeloid leukemia (AML), their progress through clinical evaluation has in part been challenged by limited knowledge of patient subgroups suitable …
View article: Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia
Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia Open
Monosomy 7 and del(7q) (-7/-7q) are frequent chromosomal abnormalities detected in up to 10% of patients with acute myeloid leukemia (AML). Despite unfavorable treatment outcomes, no approved targeted therapies exist for patients with -7/-…
View article: Monosomy 7/del(7q) Cause Sensitivity to Inhibitors of Nicotinamide Phosphoribosyltransferase in Acute Myeloid Leukemia
Monosomy 7/del(7q) Cause Sensitivity to Inhibitors of Nicotinamide Phosphoribosyltransferase in Acute Myeloid Leukemia Open
Monosomy 7 and del(7q) (-7/-7q) are frequent chromosomal abnormalities detected in up to 10% of acute myeloid leukemia (AML) patients. Despite unfavorable treatment outcomes, no approved targeted therapies exist for patients with -7/-7q. T…
View article: Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia Open
Myeloid neoplasms with erythroid or megakaryocytic differentiation include pure erythroid leukemia, myelodysplastic syndrome with erythroid features, and acute megakaryoblastic leukemia (FAB M7) and are characterized by poor prognosis and …
View article: Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML
Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML Open
[Figure: see text]
View article: Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine Open
Thrombocytopenia, prevalent in the majority of patients with myeloid malignancies, such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), is an independent adverse prognostic factor. Azacitidine (AZA), a mainstay therapeut…
View article: DrugComb: an integrative cancer drug combination data portal
DrugComb: an integrative cancer drug combination data portal Open
Drug combination therapy has the potential to enhance efficacy, reduce dose-dependent toxicity and prevent the emergence of drug resistance. However, discovery of synergistic and effective drug combinations has been a laborious and often s…
View article: DrugComb - an integrative cancer drug combination data portal
DrugComb - an integrative cancer drug combination data portal Open
Drug combination therapy has the potential to enhance efficacy, reduce dose-dependent toxicity and prevent the emergence of drug resistance. However, discovery of synergistic and effective drug combinations has been a laborious and often s…
View article: Making Sense of the Epigenome Using Data Integration Approaches
Making Sense of the Epigenome Using Data Integration Approaches Open
Epigenetic research involves examining the mitotically heritable processes that regulate gene expression, independent of changes in the DNA sequence. Recent technical advances such as whole-genome bisulfite sequencing and affordable epigen…
View article: Precision Treatment of Acute Myeloid Leukemia : Predictive Response Biomarkers for BET inhibitor JQ1
Precision Treatment of Acute Myeloid Leukemia : Predictive Response Biomarkers for BET inhibitor JQ1 Open
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the accumulation of immature and abnormally proliferating blast cells in the patient’s bone marrow and peripheral blood. Despite the mounting knowledge, there rema…
View article: The 2017 Arkema Plant Explosion following Hurricane Harvey in Crosby, Texas
The 2017 Arkema Plant Explosion following Hurricane Harvey in Crosby, Texas Open
In August of 2017, Hurricane Harvey brought destruction to southeast Texas. With the hurricane came extremely high water levels that the Crosby plant was not prepared for. In addition to underestimating the floodwaters, Arkema had not anti…
View article: A Retrospective Examination of Issues Addressed during Music Therapy Sessions with Bone Marrow Transplant Recipients
A Retrospective Examination of Issues Addressed during Music Therapy Sessions with Bone Marrow Transplant Recipients Open
Introduction: Bone marrow transplant (BMT) recipients may experience psychological and physical issues throughout the treatment process which can adversely affect outcomes. Music Therapy (MT) is a complementary treatment that may be implem…