Joseph Sheheen
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View article: Glycogen metabolism in mouse embryonic Sertoli cells sustains the germ line through the lactate shuttle
Glycogen metabolism in mouse embryonic Sertoli cells sustains the germ line through the lactate shuttle Open
Metabolites are key regulators of cell fate decisions, epigenetic remodeling, and lineage commitment. While genetic pathways governing testis differentiation are well studied, the role of metabolism remains poorly understood. In this study…
View article: Nonpathological inflammation drives the development of an avian flight adaptation
Nonpathological inflammation drives the development of an avian flight adaptation Open
The development of modern birds provides a window into the biology of their dinosaur ancestors. We investigated avian postnatal development and found that sterile inflammation drives formation of the pygostyle, a compound structure resulti…