Joseph Stanek
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View article: Phase II Study of post transplant cyclophosphamide-based graft versus host disease prophylaxis after HLA-mismatched unrelated donor transplantation and reduced intensity conditioning: Results from the NMDP-sponsored access expansion Study
Phase II Study of post transplant cyclophosphamide-based graft versus host disease prophylaxis after HLA-mismatched unrelated donor transplantation and reduced intensity conditioning: Results from the NMDP-sponsored access expansion Study Open
Allogeneic hematopoietic cell transplantation (HCT) using an HLA mismatched unrelated donor (MMUD) with calcineurin inhibitor-based graft versus host disease (GVHD) prophylaxis results in increased incidence of non-relapse mortality (NRM) …
View article: Comparing Absolute Neutrophil Counts of Children With Sickle Cell Disease With and Without the Duffy Null Phenotype
Comparing Absolute Neutrophil Counts of Children With Sickle Cell Disease With and Without the Duffy Null Phenotype Open
While nonpathogenic, the Duffy null phenotype (DN) lowers circulating neutrophils. DN is common among youth with sickle cell disease (SCD), but its implications on absolute neutrophil counts (ANC) and hydroxyurea over time are unclear. Our…
View article: The Nationwide Children’s Hospital Blood and Marrow Transplant Index: A Quality Improvement Approach to Assess the Performance of a Pediatric Blood and Marrow Transplant Program
The Nationwide Children’s Hospital Blood and Marrow Transplant Index: A Quality Improvement Approach to Assess the Performance of a Pediatric Blood and Marrow Transplant Program Open
Introduction: To design and test a metric that reflects the overall quality and safety performance of our blood and marrow transplant program (BMT) and use this metric to enhance the quality of care provided to patients. Methods: The BMT i…
View article: Prevalence and Impact of Autism Spectrum Disorder and Selected Neurodevelopmental Diagnoses in Hospitalized Youth With Sickle Cell Disease
Prevalence and Impact of Autism Spectrum Disorder and Selected Neurodevelopmental Diagnoses in Hospitalized Youth With Sickle Cell Disease Open
Background Sickle cell disease (SCD) is a chronic illness accounting for 134,000 hospital admissions annually. Youth with SCD and youth with autism spectrum disorder (ASD) experience health disparities, yet the hospitalization outcomes of …
View article: Depression Screening and Primary Care Engagement and Their Association With Socioeconomic Disadvantage Among Adolescents Aged 13–17 Years With Sickle Cell Disease
Depression Screening and Primary Care Engagement and Their Association With Socioeconomic Disadvantage Among Adolescents Aged 13–17 Years With Sickle Cell Disease Open
It is unclear if adolescents with sickle cell disease (SCD) are screened for depression, since primary care provider (PCP) visits decline with age and socioeconomic disadvantage may impact receipt of care. This 1‐year study identified 97% …
View article: Differences in Observed Outcomes and Toxicities for Adolescent and Young Adult Patients With Aggressive Mature B‐Cell Lymphomas Treated at an Adult Versus Pediatric Cancer Center
Differences in Observed Outcomes and Toxicities for Adolescent and Young Adult Patients With Aggressive Mature B‐Cell Lymphomas Treated at an Adult Versus Pediatric Cancer Center Open
Background Treatments for adolescent and young adult (AYA) patients with mature B‐cell lymphomas (MBCL) differ between adult versus pediatric centers, and data are scarce regarding comparative toxicities and outcomes. Procedures We identif…
View article: Incidence of Adrenal Insufficiency in Patients With High‐Risk Neuroblastoma: A Single‐Institution Analysis
Incidence of Adrenal Insufficiency in Patients With High‐Risk Neuroblastoma: A Single‐Institution Analysis Open
Background Neuroblastoma is the most common extracranial solid tumor in children, with about half of cases classified as high risk. Treatment varies by risk level, with high‐risk patients undergoing aggressive multimodal therapy. While lon…
View article: Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-ICU Setting
Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-ICU Setting Open
Findings suggest ketamine is safe in a non-ICU setting for treatment of complex pain during anti-GD2 immunotherapy. Additional prospective studies are needed to quantify the effect of reducing opioid side effects by including ketamine in p…
View article: Cerebral Sinus Venous Thrombosis in Children and Young Adults: Comprehensive Management and Long-Term Outcomes-A Single Institutional Experience
Cerebral Sinus Venous Thrombosis in Children and Young Adults: Comprehensive Management and Long-Term Outcomes-A Single Institutional Experience Open
View article: Reduction of Blood Transfusion in Iron Deficiency Anemia (ReBIDA): A Quality Improvement Initiative
Reduction of Blood Transfusion in Iron Deficiency Anemia (ReBIDA): A Quality Improvement Initiative Open
Background: Iron deficiency anemia (IDA) is the most common form of pediatric anemia, with first‐line treatment focusing on iron repletion through oral and/or intravenous iron. The American Society of Hematology (ASH)/the American Society …
View article: Cytomegalovirus viral load at initiation of pre‐emptive antiviral therapy impacts cytomegalovirus dynamics in pediatric allogeneic hematopoietic cell transplantation recipients
Cytomegalovirus viral load at initiation of pre‐emptive antiviral therapy impacts cytomegalovirus dynamics in pediatric allogeneic hematopoietic cell transplantation recipients Open
Background Cytomegalovirus (CMV) contributes to morbidity and mortality in allogeneic hematopoietic cell transplantation (allo‐HCT) recipients. Pre‐emptive antiviral therapy (PET) reduces the incidence of CMV end‐organ disease (EOD), thoug…
View article: Sexually transmitted infection testing and diagnosis in adolescents and young adults with sickle cell disease
Sexually transmitted infection testing and diagnosis in adolescents and young adults with sickle cell disease Open
Background Sexually transmitted infections (STIs) are common and disproportionately affect Black adolescents and young adults (AYAs). Less is known about STIs among Black AYAs with chronic conditions, such as sickle cell disease (AYAs‐SCD)…
View article: QOL-38. PSYCHOSOCIAL OUTCOMES OF CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND HIGH-GRADE GLIOMA (HGG) –PROSPECTIVE, LONGITUDINAL PROMIS ASSESSMENTS OF PATIENTS ENROLLED ON CONNECT PHASE I CLINICAL TRIALS
QOL-38. PSYCHOSOCIAL OUTCOMES OF CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND HIGH-GRADE GLIOMA (HGG) –PROSPECTIVE, LONGITUDINAL PROMIS ASSESSMENTS OF PATIENTS ENROLLED ON CONNECT PHASE I CLINICAL TRIALS Open
INTRODUCTION Given poor prognoses, children with DIPG/HGG may experience psychosocial sequelae throughout their illness journey, negatively impacting quality of life (QOL). We prospectively assessed caregiver-proxy and patient-reported psy…
View article: MDB-83. OUTCOMES OF INFANTS AND YOUNG CHILDREN WITH NEWLY DIAGNOSED SHH MEDULLOBLASTOMA TREATED ON THE NEXT CONSORTIUM “HEAD START” 4 PROTOCOL
MDB-83. OUTCOMES OF INFANTS AND YOUNG CHILDREN WITH NEWLY DIAGNOSED SHH MEDULLOBLASTOMA TREATED ON THE NEXT CONSORTIUM “HEAD START” 4 PROTOCOL Open
BACKGROUND Infants and young children with SHH medulloblastoma were demonstrated to have a favorable outcome on “Head Start (HS)” III clinical trial utilizing five cycles of induction followed by one myeloablative high-dose chemotherapy (H…
View article: TRLS-10. CLINICAL TRIAL IN PROGRESS - CONNECT2007: PHASE I/II STUDY OF LUTATHERA IN PATIENTS WITH RECURRENT AND/OR PROGRESSIVE HIGH-GRADE CENTRAL NERVOUS SYSTEM (CNS) TUMORS AND MENINGIOMAS THAT DEMONSTRATE UPTAKE ON DOTATATE PET
TRLS-10. CLINICAL TRIAL IN PROGRESS - CONNECT2007: PHASE I/II STUDY OF LUTATHERA IN PATIENTS WITH RECURRENT AND/OR PROGRESSIVE HIGH-GRADE CENTRAL NERVOUS SYSTEM (CNS) TUMORS AND MENINGIOMAS THAT DEMONSTRATE UPTAKE ON DOTATATE PET Open
BACKGROUND Somatostatin type-2A receptors (SST2A) regulate cell growth through complex downstream modulation of proliferation and apoptosis signaling, thereby representing a potential therapeutic target. Lutetium (177Lu-DOTATATE), a radion…
View article: Improving Anticoagulation Care for Pediatric Oncology Patients: A Quality Improvement Initiative
Improving Anticoagulation Care for Pediatric Oncology Patients: A Quality Improvement Initiative Open
Background: Cancer is associated with increased venous thromboembolism in children. Risk factors for venous thromboembolism in this cohort include using central venous catheters, mass effect from underlying malignancy, chemotherapy, and su…
View article: Differences in Observed Toxicities for Adolescent and Young Adult Patients with Aggressive Mature B-Cell Lymphomas Treated at Adult Versus Pediatric Cancer Center - a Comparative Cohort Study
Differences in Observed Toxicities for Adolescent and Young Adult Patients with Aggressive Mature B-Cell Lymphomas Treated at Adult Versus Pediatric Cancer Center - a Comparative Cohort Study Open
Introduction: Standard treatment regimens for pediatric and adult patients with mature B-cell lymphomas vary significantly. For adolescent or young adult (AYA) patients, who may be candidates for either pediatric or adult regimens, limited…
View article: Infection Burden and Timing in the First Year After Pediatric Allogeneic Hematopoietic Cell Transplantation: A Single-Center Experience
Infection Burden and Timing in the First Year After Pediatric Allogeneic Hematopoietic Cell Transplantation: A Single-Center Experience Open
Background Infection is a leading cause of morbidity and non-relapsed mortality (NRM) after allogeneic hematopoietic cell transplant (allo-HCT). This study aimed to describe the contemporary epidemiology of infections, overall survival (OS…
View article: Intracardiac thrombi in pediatrics: anticoagulation approach and treatment outcomes
Intracardiac thrombi in pediatrics: anticoagulation approach and treatment outcomes Open
View article: Final report of the phase II NEXT/CNS-GCT-4 trial: GemPOx followed by marrow-ablative chemotherapy for recurrent intracranial germ cell tumors
Final report of the phase II NEXT/CNS-GCT-4 trial: GemPOx followed by marrow-ablative chemotherapy for recurrent intracranial germ cell tumors Open
Background Patients with relapsed intracranial germinoma can achieve durable remission with standard chemotherapy regimens and/or reirradiation; however, innovative therapies are required for patients with relapsed and/or refractory intrac…
View article: FUTURES: efficacy and acceptability of a novel reproductive health education program for adolescent males with sickle cell disease
FUTURES: efficacy and acceptability of a novel reproductive health education program for adolescent males with sickle cell disease Open
View article: Development of a Novel Massage Therapy Outcome Measure for Children and Young Adults Receiving Hematopoietic Cell Transplant
Development of a Novel Massage Therapy Outcome Measure for Children and Young Adults Receiving Hematopoietic Cell Transplant Open
Background: Children receiving hematopoietic stem cell transplantation (HCT) often experience an unfortunate sequalae of negative effects including pain, deconditioning, and anxiety. Massage therapy (MT) has demonstrated effective non-phar…
View article: Comparison of thromboembolism outcomes in patients with sickle cell disease prescribed hormonal contraception
Comparison of thromboembolism outcomes in patients with sickle cell disease prescribed hormonal contraception Open
Patients with sickle cell disease (SCD) are at a risk of thromboembolism (TE), and use of hormonal contraception can further increase that risk. This study aims to assess patterns of hormonal contraceptive use and compare risk of contracep…
View article: Pregnancy‐related thromboembolism in women with sickle cell disease: An analysis of <scp>National Medicaid Data</scp>
Pregnancy‐related thromboembolism in women with sickle cell disease: An analysis of <span>National Medicaid Data</span> Open
Pregnancy and sickle cell disease (SCD) both individually carry a risk of thromboembolism (TE). Pregnancy in people with SCD may further enhance the prothrombotic effect of the underlying disease. The objectives of this study were to deter…
View article: HTRS2023.P4.18 Improving anticoagulation care for pediatric oncology patients
HTRS2023.P4.18 Improving anticoagulation care for pediatric oncology patients Open
S52 of S58abstracts table (Table 1) for a commonly used device and the FXaI edoxaban are shown.Data were also available for rivaroxaban and apixaban. Conclusions: Conversion tables can enable clinicians to estimateFXaI plasma activity usin…
View article: HTRS2023.P2.5 Joint surveillance with ultrasound in pediatric hemophilia A patients on emicizumab: a single institution retrospective review
HTRS2023.P2.5 Joint surveillance with ultrasound in pediatric hemophilia A patients on emicizumab: a single institution retrospective review Open
S24 of S58abstracts an alternative diagnosis for the low FVIII in most.One individual was identified with a deletion only after it was subsequently identified in her son, and she was retested with variant-specific primers.Table 1 shows the…
View article: DIPG-52. EXTRAPONTINE PROGRESSION WITH STABLE PONTINE DISEASE POST-RADIOTHERAPY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) ON A CONNECT TRIAL: IMPLICATIONS FOR RADIATION TREATMENT VOLUMES
DIPG-52. EXTRAPONTINE PROGRESSION WITH STABLE PONTINE DISEASE POST-RADIOTHERAPY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) ON A CONNECT TRIAL: IMPLICATIONS FOR RADIATION TREATMENT VOLUMES Open
Radiotherapy remains the only treatment modality proven to prolong survival and alleviate symptom burden for patients with DIPG. Upfront focal photon radiation to 54 Gy with 1-1.5cm margins is standard. Subventricular, leptomeningeal, and/…
View article: DIPG-54. UPDATED FINDINGS FROM THE PHASE IB STUDY OF UNESBULIN (PTC596) IN CHILDREN WITH NEWLY-DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND HIGH-GRADE GLIOMA (HGG): A REPORT FROM THE COLLABORATIVE NETWORK FOR NEURO-ONCOLOGY CLINICAL TRIALS (CONNECT)
DIPG-54. UPDATED FINDINGS FROM THE PHASE IB STUDY OF UNESBULIN (PTC596) IN CHILDREN WITH NEWLY-DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND HIGH-GRADE GLIOMA (HGG): A REPORT FROM THE COLLABORATIVE NETWORK FOR NEURO-ONCOLOGY CLINICAL TRIALS (CONNECT) Open
BMI-1 represents a potential therapeutic target in pediatric HGG given its role in self-renewal and DNA-damage signaling, high expression levels in these tumors, and resultant proliferation blockade, mitotic abnormalities, and radiosensiti…
View article: Peritoneal and Pleural Drains in Pediatric Hematopoietic Cell Transplant Recipients with Veno-Occlusive Disease are Safe and Do Not Adversely Impact Clinical Outcomes
Peritoneal and Pleural Drains in Pediatric Hematopoietic Cell Transplant Recipients with Veno-Occlusive Disease are Safe and Do Not Adversely Impact Clinical Outcomes Open
There is a lack of data on the safety and efficacy of peritoneal drain (PD) and chest tube (CT) in the management of effusions in stem cell transplant recipients with veno-occlusive disease (VOD). In this retrospective pediatric study, cli…
View article: Venous thromboembolism prophylaxis in sickle cell disease: a multicenter cohort study of adolescent inpatients
Venous thromboembolism prophylaxis in sickle cell disease: a multicenter cohort study of adolescent inpatients Open
Patients with sickle cell disease (SCD) are predisposed to a hypercoagulable state. Despite the increased risk of venous thromboembolism in the SCD population, there is limited evidence available to guide thromboprophylaxis (TP) practices …