Joseph V. Hajnal
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View article: Towards automated fetal brain biometry reporting for 3-dimensional T2-weighted 0.55-3T magnetic resonance imaging at 20-40 weeks gestational age range
Towards automated fetal brain biometry reporting for 3-dimensional T2-weighted 0.55-3T magnetic resonance imaging at 20-40 weeks gestational age range Open
Background The detailed assessment of fetal brain maturation and development involves morphological evaluation, gyration analysis, and reliable biometric measurements. Manual measurements on conventional 2-D magnetic resonance imaging (MRI…
View article: 7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière’s disease and endolymphatic hydrops: an exploratory study
7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière’s disease and endolymphatic hydrops: an exploratory study Open
Background Whilst delayed post-gadolinium MRI has led to a shift in the diagnostic paradigm of Meniere’s Disease (MD), there remains a strong desire to develop a non-contrast enhanced MRI technique to detect and monitor MD. The endolymphat…
View article: Low field combined diffusion-relaxation MRI for mapping placenta structure and function
Low field combined diffusion-relaxation MRI for mapping placenta structure and function Open
View article: Reducing motion artefact in high resolution 7T MRI using the Magnetic Resonance Minimal Motion (‘MR-MinMo’) head stabilisation device
Reducing motion artefact in high resolution 7T MRI using the Magnetic Resonance Minimal Motion (‘MR-MinMo’) head stabilisation device Open
Purpose To evaluate the effectiveness of the MR-MinMo head stabilisation device in mitigating motion artifacts during long-duration, high-resolution 7T MRI scans, with and without retrospective motion correction. Methods The MR-MinMo was t…
View article: Cross‐Modality Comparison of Fetal Brain Phenotypes: Insights From Short‐Interval Second‐Trimester <scp>MRI</scp> and Ultrasound Imaging
Cross‐Modality Comparison of Fetal Brain Phenotypes: Insights From Short‐Interval Second‐Trimester <span>MRI</span> and Ultrasound Imaging Open
Advances in fetal three‐dimensional (3D) ultrasound (US) and magnetic resonance imaging (MRI) have revolutionized the study of fetal brain development, enabling detailed analysis of brain structures and growth. Despite their complementary …
View article: Scanner‐based real‐time automated volumetry reporting of the fetus, amniotic fluid, placenta, and umbilical cord for fetal MRI at 0.55T
Scanner‐based real‐time automated volumetry reporting of the fetus, amniotic fluid, placenta, and umbilical cord for fetal MRI at 0.55T Open
Purpose This work aims to enable real‐time automated intra‐uterine volumetric reporting and fetal weight estimation for fetal MRI, deployed directly on the scanner. Methods A multi‐region segmentation nnUNet was trained on 146 images of 73…
View article: <scp>MR</scp> sequence design to account for nonideal gradient performance
<span>MR</span> sequence design to account for nonideal gradient performance Open
Purpose MRI systems are traditionally engineered to produce close to idealized performance, enabling a simplified pulse sequence design philosophy. An example of this is control of eddy currents produced by gradient fields; usually these a…
View article: From Offline to Inline Without Pain: A Practical Framework for Translating Offline MR Reconstructions to Inline Deployment Using the Gadgetron Platform
From Offline to Inline Without Pain: A Practical Framework for Translating Offline MR Reconstructions to Inline Deployment Using the Gadgetron Platform Open
Purpose: To develop and validate a practical framework to overcome common issues in inline deployment of established offline MR reconstruction, including (1) delay from lengthy reconstructions, (2) limited support for multi-scan input reco…
View article: 7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière’s Disease and endolymphatic hydrops: An exploratory study
7-Tesla sodium magnetic resonance imaging of the inner ears in unilateral Ménière’s Disease and endolymphatic hydrops: An exploratory study Open
Background Whilst delayed post-gadolinium MRI has led to a shift in the diagnostic paradigm of Meniere's Disease (MD), there remains a strong desire to develop a non-contrast enhanced MRI technique to detect and monitor MD. The endolymphat…
View article: Automated biometry for assessing cephalopelvic disproportion in 3D 0.55T fetal MRI at term
Automated biometry for assessing cephalopelvic disproportion in 3D 0.55T fetal MRI at term Open
Fetal MRI offers detailed three-dimensional visualisation of both fetal and maternal pelvic anatomy, allowing for assessment of the risk of cephalopelvic disproportion and obstructed labour. However, conventional measurements of fetal and …
View article: Ultra-High Field 7T MRI in a Drug-Resistant Pediatric Epilepsy Cohort
Ultra-High Field 7T MRI in a Drug-Resistant Pediatric Epilepsy Cohort Open
7T MRI in children with epilepsy is well tolerated and associated with a 23% improvement in lesion detection, directly affecting clinical management and surgical outcomes. Although limited by a preselected cohort with extensive diagnostic …
View article: 7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development
7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development Open
Human cortical development leading up to and around birth is crucial for lifelong brain function. Cortical activity can be studied using BOLD fMRI, however, previously limited sensitivity and spatial specificity has constrained understandi…
View article: Comprehensive assessment of uterine contractility using a large database of dynamic T2∗ studies
Comprehensive assessment of uterine contractility using a large database of dynamic T2∗ studies Open
Dynamic T2∗ MRI assessment of uterine contractility provides novel insights into subclinical uterine contractions and establishes a foundation for real-time detection in the future. This approach could significantly enhance our in vivo und…
View article: Associations Between Neonatal Brain Structure and Neurodevelopmental Outcomes Following Very Preterm Birth
Associations Between Neonatal Brain Structure and Neurodevelopmental Outcomes Following Very Preterm Birth Open
BackgroundVery preterm (VPT) children have high risks of neurodevelopmental delays, yet early predictors for specific impairments are poorly understood. This study investigated how neonatal brain structure relates to neurodevelopmental del…
View article: Scanner-based real-time automated volumetry reporting of the fetus, amniotic fluid, placenta and umbilical cord for fetal MRI at 0.55T
Scanner-based real-time automated volumetry reporting of the fetus, amniotic fluid, placenta and umbilical cord for fetal MRI at 0.55T Open
Purpose: This work aims to enable real-time automated intra-uterine volumetric reporting and fetal weight estimation for fetal MRI, deployed directly on the scanner. Methods: A multi-region segmentation nnUNet was trained on 146 bSSFP imag…
View article: Specific Filtered Delay Multiply and Sum beamforming for coherent multi-transducer ultrasound imaging
Specific Filtered Delay Multiply and Sum beamforming for coherent multi-transducer ultrasound imaging Open
Coherent multi-transducer ultrasound (CoMTUS) imaging enables the use of multiple arrays as one large effective aperture yielding images with enlarged field-of-view, improved resolution, and higher signal-to-noise ratio. However, creating …
View article: Towards automated multi-regional lung parcellation for 0.55-3T 3D T2w fetal MRI
Towards automated multi-regional lung parcellation for 0.55-3T 3D T2w fetal MRI Open
Fetal MRI is increasingly being employed in the diagnosis of fetal lung anomalies and segmentation-derived total fetal lung volumes are used as one of the parameters for prediction of neonatal outcomes. However, in clinical practice, segme…
View article: Common genetic variation associated with adult subcortical brain volume is also associated with subcortical brain volume at birth
Common genetic variation associated with adult subcortical brain volume is also associated with subcortical brain volume at birth Open
Introduction Recent genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with subcortical brain volumes. These studies have been undertaken in largely adult cohorts. In this work we exp…
View article: HERON: High-Efficiency Real-Time Motion Quantification and Re-Acquisition for Fetal Diffusion MRI
HERON: High-Efficiency Real-Time Motion Quantification and Re-Acquisition for Fetal Diffusion MRI Open
Fetal diffusion MRI (dMRI) provides fascinating and clinically crucial insights into the microstructure of the human brain during development, but is highly sensitive to motion artifacts of fetal movement and maternal breathing, which impa…
View article: Meta-learning Slice-to-Volume Reconstruction in Fetal Brain MRI using Implicit Neural Representations
Meta-learning Slice-to-Volume Reconstruction in Fetal Brain MRI using Implicit Neural Representations Open
High-resolution slice-to-volume reconstruction (SVR) from multiple motion-corrupted low-resolution 2D slices constitutes a critical step in image-based diagnostics of moving subjects, such as fetal brain Magnetic Resonance Imaging (MRI). E…
View article: Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis
Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis Open
Purpose This study aimed to validate a retrospective motion correction technique, Distributed and Incoherent Sample Orders for Reconstruction Deblurring using Encoding Redundancy (DISORDER), for pediatric brain morphometry. Methods Two T1-…
View article: Cortical scaling of the neonatal brain in typical and altered development
Cortical scaling of the neonatal brain in typical and altered development Open
Theoretically derived scaling laws capture the nonlinear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the preservation of these laws has not been comp…
View article: Motion‐corrected brain <scp>MRI</scp> at ultralow field (64 <scp>mT</scp> )
Motion‐corrected brain <span>MRI</span> at ultralow field (64 <span>mT</span> ) Open
Purpose The study investigates the feasibility of applying a retrospective motion‐correction technique to ultralow‐field (ULF) MRI data to improve reconstructed image quality when there is patient motion, which is likely to be a critical c…
View article: Real‐time fetal brain and placental T2* mapping at 0.55T MRI
Real‐time fetal brain and placental T2* mapping at 0.55T MRI Open
Purpose To provide real‐time, organ‐specific quantitative information — specifically placental and fetal brain T2 * — to optimize and personalize fetal MRI examinations. Methods A low‐latency setup enables real‐time processing, including s…
View article: L-FUSION: Laplacian Fetal Ultrasound Segmentation & Uncertainty Estimation
L-FUSION: Laplacian Fetal Ultrasound Segmentation & Uncertainty Estimation Open
Accurate analysis of prenatal ultrasound (US) is essential for early detection of developmental anomalies. However, operator dependency and technical limitations (e.g. intrinsic artefacts and effects, setting errors) can complicate image i…
View article: <i>In vivo</i> tractography of human neonatal white-matter pathways underlying hypothalamic and reward functions to study predispositions to neurodevelopmental conditions and obesity
<i>In vivo</i> tractography of human neonatal white-matter pathways underlying hypothalamic and reward functions to study predispositions to neurodevelopmental conditions and obesity Open
White matter (WM) tracts of the reward, limbic, and autonomic systems implicate the hypothalamus, nucleus accumbens, ventral tegmental area and the amygdala and are associated with autism, ADHD, addiction and obesity. However, since most o…
View article: Towards automated fetal brain biometry reporting for 3-dimensional T2-weighted 0.55-3T magnetic resonance imaging at 20-40 weeks gestational age range
Towards automated fetal brain biometry reporting for 3-dimensional T2-weighted 0.55-3T magnetic resonance imaging at 20-40 weeks gestational age range Open
Background: The detailed assessment of fetal brain maturation and development involves morphological evaluation, gyration analysis, and reliable biometric measurements. Manual measurements on conventional 2-D magnetic resonance imaging (MR…
View article: Video Clip Extraction From Fetal Ultrasound Scans Using Artificial Intelligence to Allow Remote Second Expert Review for Congenital Heart Disease
Video Clip Extraction From Fetal Ultrasound Scans Using Artificial Intelligence to Allow Remote Second Expert Review for Congenital Heart Disease Open
Objective To use artificial intelligence (AI) to automatically extract video clips of the fetal heart from a stream of ultrasound video, and to assess the performance of these when used for remote second review. Methods Using a dataset fro…
View article: Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project
Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project Open
Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population.…
View article: Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project
Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project Open
Increasing lines of evidence suggest white matter (WM) structural changes associated with autism can be detected in the first year of life. Despite the condition having high heritability, the relationship between autism common genetic vari…