Vincent J. Venditto
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View article: Systematic development and optimization of a microfluidic formulation protocol for liposomal azithromycin
Systematic development and optimization of a microfluidic formulation protocol for liposomal azithromycin Open
Optimized microfluidic manufacturing parameters for optimized liposomal azithromycin formulation properties.
View article: Promoting Cultural Humility by Integrating Health Equity Literature into the Pharmacy Curriculum
Promoting Cultural Humility by Integrating Health Equity Literature into the Pharmacy Curriculum Open
Strategies that introduce students to unconscious bias and social determinants of health (SDOH) are critical to develop them as effective health care providers. We developed a semester-long activity that utilizes disease-relevant scientifi…
View article: Optimization and Characterization of a Liposomal Azithromycin Formulation for Alternative Macrophage Activation
Optimization and Characterization of a Liposomal Azithromycin Formulation for Alternative Macrophage Activation Open
Liposomal azithromycin (L-AZM) promotes macrophage polarization toward an M2-like phenotype in the context of myocardial infarction that results in improved cardiovascular outcomes in mice. To improve upon this formulation, we sought to id…
View article: <i>In vivo</i>assessment of triazine lipid nanoparticles as transfection agents for plasmid DNA
<i>In vivo</i>assessment of triazine lipid nanoparticles as transfection agents for plasmid DNA Open
A triazine based lipid was evaluated in mice for toxicity and transfection efficiency using optimized formulation parameters that result in improved transgene expression as compared to formulations containing commercially available cationi…
View article: Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19
Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19 Open
The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the im…
View article: Cyanuric chloride as the basis for compositionally diverse lipids
Cyanuric chloride as the basis for compositionally diverse lipids Open
Cyanuric chloride enables facile synthesis of lipids with unique biophysical properties for use in gene and vaccine delivery.
View article: Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction
Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction Open
A growing body of evidence shows that altering the inflammatory response by alternative macrophage polarization is protective against complications related to acute myocardial infarction (MI). We have previously shown that oral azithromyci…
View article: Everything Is Science: A Free City-Wide Science Festival
Everything Is Science: A Free City-Wide Science Festival Open
A week-long, city-wide science festival called Everything is Science (EiS) was developed to educate the community in an informal manner. The festival serves as a platform for presenters from diverse professions to give engaging talks (with…
View article: Autoantibody Responses to Apolipoprotein A-I Are Not Diet- or Sex-Linked in C57BL/6 Mice
Autoantibody Responses to Apolipoprotein A-I Are Not Diet- or Sex-Linked in C57BL/6 Mice Open
Atherosclerosis is responsible for a large percentage of all-cause mortality worldwide, but it is only now beginning to be understood as a complex disease process involving metabolic insult, chronic inflammation, and multiple immune mechan…
View article: 4222 Synthesis and application of cyanuric chloride lipids for peptide presentation
4222 Synthesis and application of cyanuric chloride lipids for peptide presentation Open
OBJECTIVES/GOALS: My long-term career objective is to become an established independent researcher focused on understanding and modulating immune responses to biologics in order to enhance their efficacy and understand the underlying mecha…
View article: Association Between ApoA-I (Apolipoprotein A-I) Immune Complexes and Adverse Cardiovascular Events—Brief Report
Association Between ApoA-I (Apolipoprotein A-I) Immune Complexes and Adverse Cardiovascular Events—Brief Report Open
Objective: The immune response is linked to the progression of atherosclerotic cardiovascular disease (CVD). Free autoantibodies targeting ApoA-I (apolipoprotein A-I) have been identified as a component of the inflammatory milieu in patien…
View article: Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease
Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease Open
Azithromycin plays a cardioprotective role in the early phase post-MI through attenuating inflammation and enhancing cardiac recovery. Post-MI treatment and human translational studies are warranted to examine the therapeutic applications …
View article: Bioactivities by a crude extract from the Greenlandic<i>Pseudomonas</i>sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin
Bioactivities by a crude extract from the Greenlandic<i>Pseudomonas</i>sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin Open
Background. Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp. In5 is a biocontrol strain isolated from a plant disease suppressive soil in Greenland…