Joseph W. Shelton
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View article: Risk factors and clinical outcomes of radiation-induced fistula after chemoradiation and image-guided brachytherapy for locally advanced cervical cancer
Risk factors and clinical outcomes of radiation-induced fistula after chemoradiation and image-guided brachytherapy for locally advanced cervical cancer Open
View article: Associations among HPV persistence, the vaginal microbiome, and cervical cancer recurrence
Associations among HPV persistence, the vaginal microbiome, and cervical cancer recurrence Open
Our findings link Prevotella-dominant, high diversity vaginal microbiome communities with post-therapy hrHPV persistence and cervical cancer recurrence in gynecologic cancer survivors. Such findings warrant further research into the role o…
View article: CT-guided CBCT multi-organ segmentation using a multi-channel conditional consistency diffusion model for lung cancer radiotherapy
CT-guided CBCT multi-organ segmentation using a multi-channel conditional consistency diffusion model for lung cancer radiotherapy Open
In cone beam computed tomography (CBCT)-guided adaptive radiotherapy, rapid and precise segmentation of organs-at-risk (OARs) is essential for accurate dose verification and online replanning. The quality of CBCT images obtained with curre…
View article: Impact of Rectal Spacer on Toxicity Reduction in Men Treated With Proton Versus Photon Therapy
Impact of Rectal Spacer on Toxicity Reduction in Men Treated With Proton Versus Photon Therapy Open
View article: Patterns of Undertreatment and Overtreatment in Adjuvant Radiotherapy for Early-Stage Endometrial Cancer Based on Molecular Classification
Patterns of Undertreatment and Overtreatment in Adjuvant Radiotherapy for Early-Stage Endometrial Cancer Based on Molecular Classification Open
The quality improvement study examines the use of risk-adaptive adjuvant radiotherapy in women with non–mismatch repair deficiency endometrial cancer.
View article: Implementation of a Novel Chart Rounds Application to Facilitate Peer Review in a Virtual Academic Environment
Implementation of a Novel Chart Rounds Application to Facilitate Peer Review in a Virtual Academic Environment Open
View article: P2.31-04 Implementation of a Novel Chart Rounds Application to Facilitate Lung Radiotherapy Plan Peer-Review in a Virtual Environment
P2.31-04 Implementation of a Novel Chart Rounds Application to Facilitate Lung Radiotherapy Plan Peer-Review in a Virtual Environment Open
View article: EP08.02-37 Definitive Hypofractionated Radiation Therapy with or without Immunotherapy for Stage IIb-III NSCLC: An Institutional Experience
EP08.02-37 Definitive Hypofractionated Radiation Therapy with or without Immunotherapy for Stage IIb-III NSCLC: An Institutional Experience Open
View article: Risk Factors and Clinical Features of Fistula after Concurrent Chemoradiation and Brachytherapy for Locally Advanced Cervical Cancer
Risk Factors and Clinical Features of Fistula after Concurrent Chemoradiation and Brachytherapy for Locally Advanced Cervical Cancer Open
View article: Data-Driven Volumetric Image Generation from Surface Structures using a Patient-Specific Deep Leaning Model
Data-Driven Volumetric Image Generation from Surface Structures using a Patient-Specific Deep Leaning Model Open
The advent of computed tomography significantly improves patient health regarding diagnosis, prognosis, and treatment planning and verification. However, tomographic imaging escalates concomitant radiation doses to patients, inducing poten…
View article: 2D medical image synthesis using transformer-based denoising diffusion probabilistic model
2D medical image synthesis using transformer-based denoising diffusion probabilistic model Open
Objective . Artificial intelligence (AI) methods have gained popularity in medical imaging research. The size and scope of the training image datasets needed for successful AI model deployment does not always have the desired scale. In thi…
View article: Supplementary Figure Legends from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Supplementary Figure Legends from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer Open
PDF file - 70KB
View article: Supplementary Figures 1 - 6 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Supplementary Figures 1 - 6 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer Open
PDF file - 981KB, Representative Immunohistochemistry for CHD7 Expression in Primary Tumor Tissue (S1). Network Analysis via MetaCore ExPlain Process Network Analysis for genes involved in CHK1, CDC25A, AURKB, PLK1, HUS1 pathway (S2). CHD7…
View article: Data from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Data from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor outcomes with current therapies. Gemcitabine is the primary adjuvant drug used clinically, but its effectiveness is limited. In this study, our objective was to use…
View article: Supplementary Figure Legends from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Supplementary Figure Legends from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer Open
PDF file - 70KB
View article: Data from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Data from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor outcomes with current therapies. Gemcitabine is the primary adjuvant drug used clinically, but its effectiveness is limited. In this study, our objective was to use…
View article: Supplementary Tables 1 - 4 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Supplementary Tables 1 - 4 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer Open
XLS file - 675KB, Full Results of Primary Gemcitabine Sensitivity Screen (S1). Known DNA Damage Response Genes Identified as Hits in Gemcitabine Sensitivity Screen (S2). Dysregulation, Differential Expression, and Literature RNAi Cross-Ref…
View article: Supplementary Tables 1 - 4 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Supplementary Tables 1 - 4 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer Open
XLS file - 675KB, Full Results of Primary Gemcitabine Sensitivity Screen (S1). Known DNA Damage Response Genes Identified as Hits in Gemcitabine Sensitivity Screen (S2). Dysregulation, Differential Expression, and Literature RNAi Cross-Ref…
View article: Supplementary Figures 1 - 6 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Supplementary Figures 1 - 6 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer Open
PDF file - 981KB, Representative Immunohistochemistry for CHD7 Expression in Primary Tumor Tissue (S1). Network Analysis via MetaCore ExPlain Process Network Analysis for genes involved in CHK1, CDC25A, AURKB, PLK1, HUS1 pathway (S2). CHD7…
View article: Impact of 18F-Fluciclovine PET/CT Findings on Failure-Free Survival in Biochemical Recurrence of Prostate Cancer Following Salvage Radiation Therapy
Impact of 18F-Fluciclovine PET/CT Findings on Failure-Free Survival in Biochemical Recurrence of Prostate Cancer Following Salvage Radiation Therapy Open
Purpose We aimed to evaluate the impact of 18 F-fluciclovine PET/CT imaging on failure-free survival (FFS) post–salvage radiotherapy (SRT) for prostate cancer (PCa) recurrence. Methods Seventy-nine patients were recruited in a phase 2/3 cl…
View article: Definitive intensity modulated proton re-irradiation for lung cancer in the immunotherapy era
Definitive intensity modulated proton re-irradiation for lung cancer in the immunotherapy era Open
Introduction As immunotherapy has improved distant metastasis-free survival (DMFS) in Non-Small Cell Lung Cancer (NSCLC), isolated locoregional recurrences have increased. However, management of locoregional recurrences can be challenging.…
View article: Differences in Failure-Free Survival After Salvage Radiotherapy Guided by Conventional Imaging Versus<sup>18</sup>F-Fluciclovine PET/CT in Postprostatectomy Patients: A Post Hoc Substratification Analysis of the EMPIRE-1 Trial
Differences in Failure-Free Survival After Salvage Radiotherapy Guided by Conventional Imaging Versus<sup>18</sup>F-Fluciclovine PET/CT in Postprostatectomy Patients: A Post Hoc Substratification Analysis of the EMPIRE-1 Trial Open
The EMPIRE-1 (Emory Molecular Prostate Imaging for Radiotherapy Enhancement 1) trial reported a survival advantage in recurrent prostate cancer salvage radiotherapy (SRT) guided by 18F-fluciclovine PET/CT versus conventional ima…
View article: Incidence and predictors of toxicity in the management of vulvar squamous cell carcinoma treated with radiation therapy
Incidence and predictors of toxicity in the management of vulvar squamous cell carcinoma treated with radiation therapy Open
RT for vulvar cancer is associated with considerable rates of severe acute and late toxicity and PSS burden. Larger studies are needed to identify risk factors, explore toxicity mitigation strategies, and assess patient-reported outcomes.
View article: Changes in the Vaginal Microbiome and Associated Toxicities Following Radiation Therapy for Gynecologic Cancers
Changes in the Vaginal Microbiome and Associated Toxicities Following Radiation Therapy for Gynecologic Cancers Open
Postmenopausal women often suffer from vaginal symptoms associated with atrophic vaginitis. Additionally, gynecologic cancer survivors may live for decades with additional, clinically significant, persistent vaginal toxicities caused by ca…
View article: Severe Toxicity and Provider-Reported Subjective Symptoms in Patients With Vulvar Cancer Receiving Curative-Intent Radiotherapy
Severe Toxicity and Provider-Reported Subjective Symptoms in Patients With Vulvar Cancer Receiving Curative-Intent Radiotherapy Open
View article: Clinical Outcomes and Assessment of Racial Disparities for Vulvar Squamous Cell Carcinoma Treated With Radiotherapy
Clinical Outcomes and Assessment of Racial Disparities for Vulvar Squamous Cell Carcinoma Treated With Radiotherapy Open
View article: Randomized Trial of Conventional vs Conventional Plus Fluciclovine (18F) PET/CT-Guided Post-Prostatectomy Radiotherapy for Prostate Cancer: Volumetric and Patient-Reported Toxicity Analyses
Randomized Trial of Conventional vs Conventional Plus Fluciclovine (18F) PET/CT-Guided Post-Prostatectomy Radiotherapy for Prostate Cancer: Volumetric and Patient-Reported Toxicity Analyses Open
View article: Deep learning-based thoracic CBCT correction with histogram matching
Deep learning-based thoracic CBCT correction with histogram matching Open
Kilovoltage cone-beam computed tomography (CBCT)-based image-guided radiation therapy (IGRT) is used for daily delivery of radiation therapy, especially for stereotactic body radiation therapy (SBRT), which imposes particularly high demand…
View article: FP08.01 Lung Stereotactic Body Radiation Therapy for Treatment of Oligoprogressive and Oligorecurrent Metastatic Disease: A Multi-Center Analysis
FP08.01 Lung Stereotactic Body Radiation Therapy for Treatment of Oligoprogressive and Oligorecurrent Metastatic Disease: A Multi-Center Analysis Open
View article: Influence of Timing Between Androgen Deprivation Therapy and External Beam Radiation Therapy in Patients With Localized, High-Risk Prostate Cancer
Influence of Timing Between Androgen Deprivation Therapy and External Beam Radiation Therapy in Patients With Localized, High-Risk Prostate Cancer Open