Joseph Willis
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View article: NONENDOSCOPIC DETECTION OF BARRETT’S ESOPHAGUS IN PATIENTS WITHOUT GERD SYMPTOMS
NONENDOSCOPIC DETECTION OF BARRETT’S ESOPHAGUS IN PATIENTS WITHOUT GERD SYMPTOMS Open
Background Screening efforts for Barrett’s Esophagus (BE) predominantly focus on performing upper endoscopy (EGD) on patients with gastroesophageal reflux disease (GERD) symptoms who have additional risk factors for BE. However, cost and i…
View article: Multicenter, Prospective Trial of Nonendoscopic Biomarker-Driven Detection of Barrett's Esophagus and Esophageal Adenocarcinoma
Multicenter, Prospective Trial of Nonendoscopic Biomarker-Driven Detection of Barrett's Esophagus and Esophageal Adenocarcinoma Open
INTRODUCTION: Preliminary data suggest that an encapsulated balloon (EsoCheck), coupled with a 2 methylated DNA biomarker panel (EsoGuard), detects Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) with high accuracy. The initia…
View article: Neutrophil extracellular traps induced by chemotherapy inhibit tumor growth in murine models of colorectal cancer
Neutrophil extracellular traps induced by chemotherapy inhibit tumor growth in murine models of colorectal cancer Open
Neutrophil extracellular traps (NETs), a web-like structure of cytosolic and granule proteins assembled on decondensed chromatin, kill pathogens and cause tissue damage in diseases. Whether NETs can kill cancer cells is unexplored. Here, w…
View article: Patients With Esophageal Adenocarcinoma With Prior Gastroesophageal Reflux Disease Symptoms Are Similar to Those Without Gastroesophageal Reflux Disease: A Cross-Sectional Study
Patients With Esophageal Adenocarcinoma With Prior Gastroesophageal Reflux Disease Symptoms Are Similar to Those Without Gastroesophageal Reflux Disease: A Cross-Sectional Study Open
INTRODUCTION: A substantial proportion of patients with esophageal adenocarcinoma (EAC) do not report gastroesophageal reflux disease (GERD) symptoms. This study aimed to compare the risk factor profiles and cancer stage at presentation of…
Identifying primary tumor site of origin for liver metastases via a combination of handcrafted and deep learning features Open
Liver is one of the most common sites for metastases, which can occur on account of primary tumors from multiple sites of origin. Identifying the primary site of origin (PSO) of a metastasis can help in guiding therapeutic options for live…
View article: Multi-Institutional Evaluation of Pathologists’ Assessment Compared to Immunoscore
Multi-Institutional Evaluation of Pathologists’ Assessment Compared to Immunoscore Open
Background: The Immunoscore (IS) is a quantitative digital pathology assay that evaluates the immune response in cancer patients. This study reports on the reproducibility of pathologists’ visual assessment of CD3+- and CD8+-stained colon …
View article: Increased glucose availability sensitizes pancreatic cancer to chemotherapy
Increased glucose availability sensitizes pancreatic cancer to chemotherapy Open
Pancreatic Ductal Adenocarcinoma (PDAC) is highly resistant to chemotherapy. Effective alternative therapies have yet to emerge, as chemotherapy remains the best available systemic treatment. However, the discovery of safe and available ad…
View article: NON-ENDOSCOPIC ESOPHAGEAL SAMPLING DEVICE AND BIOMARKER PANEL FOR DETECTION OF BARRETT’S ESOPHAGUS (BE) AND ESOPHAGEAL ADENOCARCINOMA (EAC)
NON-ENDOSCOPIC ESOPHAGEAL SAMPLING DEVICE AND BIOMARKER PANEL FOR DETECTION OF BARRETT’S ESOPHAGUS (BE) AND ESOPHAGEAL ADENOCARCINOMA (EAC) Open
BACKGROUND We previously reported an encapsulated balloon (EsoCheck TM , EC), which selectively samples the distal esophagus, that coupled with a two methylated DNA biomarker panel (EsoGuard TM , EG), detected Barrett’s esophagus (BE) and …
Potential role of fructose on human colon DNA methylation in racial disparities observed for colorectal cancer risk Open
Background and aims An increasing body of observational studies has linked fructose intake to colorectal cancer (CRC). African Americans (AAs) are significantly more likely than European Americans to consume greater quantities of fructose …
View article: Supplementary Figure from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant <i>KRAS</i>
Supplementary Figure from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant <i>KRAS</i> Open
Supplementary Figure from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS
Data from Inactivating Mutation in the Prostaglandin Transporter Gene, <i>SLCO2A1</i>, Associated with Familial Digital Clubbing, Colon Neoplasia, and NSAID Resistance Open
HPGDand SLCO2A1 genes encode components of the prostaglandin catabolic pathway, with HPGD encoding the degradative enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), and SLCO2A1 encoding the prostaglandin transporter PGT that brings s…
Supplementary Tables 1 - 2 from Inactivating Mutation in the Prostaglandin Transporter Gene, <i>SLCO2A1</i>, Associated with Familial Digital Clubbing, Colon Neoplasia, and NSAID Resistance Open
PDF file - 28KB, Table S1: PCR primer sequences for amplification of SLCO2A1 (c.584C>A, p.104G>STOP) mutant position in germline DNA. Table S2: PCR primer sequences for amplification of SLCO2A1 coding sequence in formalin-fixed paraffin-em…
Supplementary Tables 1 - 2 from Inactivating Mutation in the Prostaglandin Transporter Gene, <i>SLCO2A1</i>, Associated with Familial Digital Clubbing, Colon Neoplasia, and NSAID Resistance Open
PDF file - 28KB, Table S1: PCR primer sequences for amplification of SLCO2A1 (c.584C>A, p.104G>STOP) mutant position in germline DNA. Table S2: PCR primer sequences for amplification of SLCO2A1 coding sequence in formalin-fixed paraffin-em…
View article: Supplementary Figure from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant <i>KRAS</i>
Supplementary Figure from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant <i>KRAS</i> Open
Supplementary Figure from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS
View article: Data from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant <i>KRAS</i>
Data from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant <i>KRAS</i> Open
We previously identified that human epidermal growth factor receptor 3 (HER3, also known as ERBB3) is a key mediator in liver endothelial cell (EC) promoting colorectal cancer growth and chemoresistance, and suggested HER3-targeted therapy…
Data from Inactivating Mutation in the Prostaglandin Transporter Gene, <i>SLCO2A1</i>, Associated with Familial Digital Clubbing, Colon Neoplasia, and NSAID Resistance Open
HPGDand SLCO2A1 genes encode components of the prostaglandin catabolic pathway, with HPGD encoding the degradative enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), and SLCO2A1 encoding the prostaglandin transporter PGT that brings s…
View article: Data from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant <i>KRAS</i>
Data from Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant <i>KRAS</i> Open
We previously identified that human epidermal growth factor receptor 3 (HER3, also known as ERBB3) is a key mediator in liver endothelial cell (EC) promoting colorectal cancer growth and chemoresistance, and suggested HER3-targeted therapy…
View article: Supplementary Figure 1 from Aberrant Vimentin Methylation Is Characteristic of Upper Gastrointestinal Pathologies
Supplementary Figure 1 from Aberrant Vimentin Methylation Is Characteristic of Upper Gastrointestinal Pathologies Open
PDF file - 41K
Supplementary Methods and Materials. Supplementary Tables S1-S4 from Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm Open
Supplementary Methods of imputation of age and estimating the parameters of the prediction model. Supplementary Table S1 Missing rates on the 8 covariates in the training and validation datasets. Supplementary Table S2 Stepwise removal of …
Supplementary Table 2 from A Segregation Analysis of Barrett's Esophagus and Associated Adenocarcinomas Open
Supplementary Table 2 from A Segregation Analysis of Barrett's Esophagus and Associated Adenocarcinomas
View article: Data from Aberrant Vimentin Methylation Is Characteristic of Upper Gastrointestinal Pathologies
Data from Aberrant Vimentin Methylation Is Characteristic of Upper Gastrointestinal Pathologies Open
Background: We have previously established aberrant DNA methylation of vimentin exon-1 (VIM methylation) as a common epigenetic event in colon cancer and as a biomarker for detecting colon neoplasia. We now examine vimentin methylation in …
Supplementary Figures from RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas Open
Contains Supplementary Figures 1-3 as follows: Supplementary Figure 1: Full-length sequence and protein domains of RPS6KB1-VMP1 and OSBPL1A-LAMA3 fusion transcripts identified in EACs Supplementary Figure 2: Somatic copy-number aberrations…