Joseph Withrow
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View article: The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer’s Disease
The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer’s Disease Open
Alzheimer's disease (AD) is characterized by the presence of two hallmark pathologies: the accumulation of Amyloid beta (Aβ) and tau proteins in the brain. There is a growing body of evidence suggesting that astrocytes, a type of glial cel…
View article: Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury
Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury Open
Recent studies have revealed the heterogeneous nature of astrocytes; however, how diverse constituents of astrocyte-lineage cells are regulated in adult spinal cord after injury and contribute to regeneration remains elusive. We perform si…
View article: Case report of hyperacute edema and cavitation following deep brain stimulation lead implantation
Case report of hyperacute edema and cavitation following deep brain stimulation lead implantation Open
Background: Postoperative cerebral edema around a deep brain stimulation (DBS) electrode is an uncommonly reported complication of DBS surgery. The etiology of this remains unknown, and the presentation is highly variable; however, the pat…
View article: The Evolution of the Neurosurgical Treatment of Ischemic Stroke
The Evolution of the Neurosurgical Treatment of Ischemic Stroke Open
The neurosurgical approach to the management of ischemic stroke has evolved dramatically over the past century with the bulk of these changes occurring over the past 25 years. With recent advances in technology and continued refinements in…
View article: Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis
Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis Open
Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause significant morbidity in the US population. Extracellular vesicles (EVs), including exosomes and microvesicles, are now recognized to play importan…