Joseph Zinski
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View article: T follicular helper cells are mis-localized in idiopathic multicentric castleman disease
T follicular helper cells are mis-localized in idiopathic multicentric castleman disease Open
Idiopathic multicentric Castleman disease (iMCD) is an atypical hematologic disorder with significant morbidity and mortality. Defined by enlarged lymph nodes (LN) with characteristic histopathology, there are a range of clinical subtypes …
View article: Somatic mutation discovery in idiopathic multicentric castleman disease (iMCD) lymph node tissue identifies dysregulated intracellular calcium signaling as a potential disease mechanism and therapeutic target
Somatic mutation discovery in idiopathic multicentric castleman disease (iMCD) lymph node tissue identifies dysregulated intracellular calcium signaling as a potential disease mechanism and therapeutic target Open
Background: Idiopathic multicentric Castleman disease (iMCD) is a rare, atypical lymphoproliferative disorder with significant morbidity and mortality and unknown etiology. Given the clinico-pathologic similarities between iMCD and several…
View article: Increased type I interferon signaling is a hallmark of idiopathic multicentric castleman disease
Increased type I interferon signaling is a hallmark of idiopathic multicentric castleman disease Open
Human herpesvirus (HHV)-8-negative, idiopathic multicentric Castleman disease (iMCD) is a rare hematologic illness involving progressive flares of inflammation, lymphoproliferation, and cytokine-induced organ failure. While there is an FDA…
View article: Oocyte polarity is established independently of the Balbiani body
Oocyte polarity is established independently of the Balbiani body Open
In most animals, oocyte polarity establishes the embryonic body plan by asymmetrically localizing axis-determining transcripts. These transcripts first localize in Xenopus and zebrafish oocytes to the Balbiani body (Bb), a large membrane-l…
View article: A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model
A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model Open
View article: Rare Disease Drug Repurposing
Rare Disease Drug Repurposing Open
Importance Treatments are urgently needed for the more than 9500 rare diseases with no US Food and Drug Administration–approved therapies. Although repurposing can be less time- and cost-intensive compared with novel drug development, hurd…
View article: A fine kinetic balance of interactions directs transcription factor hubs to genes
A fine kinetic balance of interactions directs transcription factor hubs to genes Open
Eukaryotic gene regulation relies on the binding of sequence-specific transcription factors (TFs). TFs bind chromatin transiently yet occupy their target sites by forming high-local concentration microenvironments (hubs and condensates) th…
View article: EpicTope: narrating protein sequence features to identify non-disruptive epitope tagging sites
EpicTope: narrating protein sequence features to identify non-disruptive epitope tagging sites Open
Epitope tagging is an invaluable technique enabling the identification, tracking, and purification of proteins in vivo. We developed a tool, EpicTope, to facilitate this method by identifying amino acid positions suitable for epitope inser…
View article: Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers
Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers Open
Background Proteins of the TGFβ family, which are largely studied as homodimers, are also known to form heterodimers with biological activity distinct from their component homodimers. For instance, heterodimers of bone morphogenetic protei…
View article: Networks of necessity: Simulating COVID-19 mitigation strategies for disabled people and their caregivers
Networks of necessity: Simulating COVID-19 mitigation strategies for disabled people and their caregivers Open
A major strategy to prevent the spread of COVID-19 is the limiting of in-person contacts. However, limiting contacts is impractical or impossible for the many disabled people who do not live in care facilities but still require caregivers …
View article: Bmper is required for morphogenesis of the anterior and posterior semicircular canal ducts in the developing zebrafish inner ear
Bmper is required for morphogenesis of the anterior and posterior semicircular canal ducts in the developing zebrafish inner ear Open
Summary BMP signalling is known to have a conserved function in development of the semicircular canal system of the vertebrate inner ear, but its regulation, target genes and effects on cell behaviour during otic morphogenesis are not full…
View article: Networks of Necessity: Simulating Strategies for COVID-19 Mitigation among Disabled People and Their Caregivers
Networks of Necessity: Simulating Strategies for COVID-19 Mitigation among Disabled People and Their Caregivers Open
A major strategy to prevent the spread of COVID-19 is through the limiting of in-person contacts. However, for the many disabled people who live in the community and require caregivers to assist them with activities of daily living, limiti…
View article: Networks of Necessity: Simulating COVID-19 Mitigation Strategies for Disabled People and Their Caregivers
Networks of Necessity: Simulating COVID-19 Mitigation Strategies for Disabled People and Their Caregivers Open
A major strategy to prevent the spread of COVID-19 is the limiting of in-person contacts. However, this is impractical or impossible for the many disabled people who do not live in care facilities, but still require caregivers. We seek to …
View article: A Primary Care Provider's Guide to Bone Health in Spinal Cord-Related Paralysis
A Primary Care Provider's Guide to Bone Health in Spinal Cord-Related Paralysis Open
Individuals with spinal cord injury/disorder (SCI/D) are at high risk for developing secondary osteoporosis. Bone loss after neurologic injury is multifactorial and is dependent on the time from and extent of neurologic injury. Most bone l…
View article: Systems biology derived source-sink mechanism of BMP gradient formation
Systems biology derived source-sink mechanism of BMP gradient formation Open
A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral embryonic axis of vertebrates and invertebrates. The prevailing view in vertebrates for BMP gradient formation is through a counter-gradient of BM…
View article: TGF-β Family Signaling in Early Vertebrate Development
TGF-β Family Signaling in Early Vertebrate Development Open
TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate embryonic body plan. Nodal signaling is essential for the specification of mesendodermal tissues and the concurrent cellular movements of gastrul…
View article: Author response: Systems biology derived source-sink mechanism of BMP gradient formation
Author response: Systems biology derived source-sink mechanism of BMP gradient formation Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract A morphogen gradient of Bone Morphogenetic Prot…
View article: Systems Biology Derived Mechanism Of Bmp Gradient Formation
Systems Biology Derived Mechanism Of Bmp Gradient Formation Open
A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral (DV) axis of all vertebrates. This gradient is established by the extracellular interaction of the asymmetric expression of the BMP ligand and its…