Josh McGovern
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View article: Does Modified 5‐Item Frailty Index Correlate With Survival in Oropharyngeal Squamous Cell Carcinoma?
Does Modified 5‐Item Frailty Index Correlate With Survival in Oropharyngeal Squamous Cell Carcinoma? Open
Introduction Oropharyngeal squamous cell cancer (OPSCC) is a common subtype of head and neck cancer. It is generally stratified into high, intermediate, and low risk prognostic groups on the basis of HPV (human papillomavirus) status and s…
View article: The Global Leadership Initiative on Malnutrition (GLIM) inflammation criteria to predict survival in patients with advanced cancer: A prospective cohort study
The Global Leadership Initiative on Malnutrition (GLIM) inflammation criteria to predict survival in patients with advanced cancer: A prospective cohort study Open
Systemic inflammation, as assessed by CRP, mGPS and NLR, significantly improves the relationship between phenotypic criteria and OS. These findings support the GLIM framework's inclusion of systemic inflammation as a critical factor. Given…
View article: The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer
The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer Open
Background Systemic inflammation has prognostic value in cancer and is considered aetiological of cachexia by the Global Leadership Initiative on Malnutrition (GLIM). Lactate dehydrogenase (LDH) also has recognized prognostic value. The pr…
View article: The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer
The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer Open
Background In cancer cachexia the relationship between the tumour, its environment and the systemic inflammatory response is not clear. This study aims to examine this relationship in greater detail. Methods Host characteristics included t…
View article: The prevalence and prognostic value of systemic inflammation in good performance status patients with advanced, inoperable non‐small cell lung cancer receiving palliative radiotherapy: Comparison of composite ratios and cumulative scores
The prevalence and prognostic value of systemic inflammation in good performance status patients with advanced, inoperable non‐small cell lung cancer receiving palliative radiotherapy: Comparison of composite ratios and cumulative scores Open
Introduction The present study sought to examine the relationships between systemic inflammatory composite ratios/cumulative scores, magnitude of systemic inflammatory response (SIR) and survival in good performance status patients (ECOG‐P…
View article: CT-derived body composition and differential association with age, TNM stage and systemic inflammation in patients with colon cancer
CT-derived body composition and differential association with age, TNM stage and systemic inflammation in patients with colon cancer Open
View article: Routine assessment of nutritional, functional and inflammatory criteria in patients with cancer: A systematic review
Routine assessment of nutritional, functional and inflammatory criteria in patients with cancer: A systematic review Open
The present systematic review highlights the variability and lack of standardization in the application of GLIM criteria for monitoring cachexia in cancer patients. Despite these challenges, it will be important to determine the most effic…
View article: Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series
Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series Open
Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers fea…
View article: The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis
The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis Open
Current literature suggests elevated serum LDH is associated with inflammation in cancer (an aetiologic GLIM criterion), however more work is required to establish the relationship between LDH and the phenotypic components of GLIM. Additio…
View article: The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer Does tumour necrosis drive cachexia?
The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer Does tumour necrosis drive cachexia? Open
Background: In cancer cachexia the relationship between the tumour, its environment and the systemic inflammatory response is not clear. This study aims to examine this relationship in greater detail. Methods: Host characteristics included…
View article: Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study
Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study Open
Background Features of cancer cachexia adversely influence patient outcomes, yet few currently inform clinical decision-making. This study assessed the value of the cachexia index (CXI), a novel prognostic marker, in patients for whom neoa…
View article: CT-derived body composition: Differential association with disease, age and inflammation in a retrospective cohort study
CT-derived body composition: Differential association with disease, age and inflammation in a retrospective cohort study Open
Background Low skeletal muscle mass and density, as assessed by CT-body composition (CT-BC), are recognised to have prognostic value in non-cancer and cancer patients. The aim of the present study was to compare CT-BC parameters between no…
View article: Comment on “A promising prognostic grading system incorporating weight loss and inflammation in patients with advanced cancer” by Zhang et al.
Comment on “A promising prognostic grading system incorporating weight loss and inflammation in patients with advanced cancer” by Zhang et al. Open
Dear Editor, We read the manuscript 'A promising prognostic grading system incorporating weight loss and inflammation in patients with advanced cancer' by Zhang and co-workers with considerable interest. The authors are to be congratulated…
View article: The Relationship between Liver Volume, Clinicopathological Characteristics and Survival in Patients Undergoing Resection with Curative Intent for Non-Metastatic Colonic Cancer
The Relationship between Liver Volume, Clinicopathological Characteristics and Survival in Patients Undergoing Resection with Curative Intent for Non-Metastatic Colonic Cancer Open
Introduction: The prognostic value of CT-derived liver volume in terms of cancer outcomes is not clear. The aim of the present study was to examine the relationship between liver area on a single axial CT-slice and the total liver volume i…
View article: The relationship between clinicopathological variables, systemic inflammation, and <scp>CT</scp>‐derived body composition with survival in patients with advanced non‐small cell lung cancer receiving nivolumab as a second‐line treatment
The relationship between clinicopathological variables, systemic inflammation, and <span>CT</span>‐derived body composition with survival in patients with advanced non‐small cell lung cancer receiving nivolumab as a second‐line treatment Open
Background Second‐line immunotherapy is currently recognized to help only a subset of patients with advanced forms of non‐small cell lung cancer (NSCLC). The current study analyzes the connection between prior treatment host/tumor characte…
View article: SP5.7 Prognostic Value of ‘Cachexia Index’ in Patients with Colorectal Cancer Undergoing Surgical Resection
SP5.7 Prognostic Value of ‘Cachexia Index’ in Patients with Colorectal Cancer Undergoing Surgical Resection Open
Aim Numerous phenotypical features of cachexia have been associated with poorer outcomes in patients with cancer. However, at present, very few of these markers are routinely considered during the shared decision-making process. This study…
View article: SP6.5 Outcomes in Oesophagogastric Cancer up to 18 months following the COVID-19 pandemic
SP6.5 Outcomes in Oesophagogastric Cancer up to 18 months following the COVID-19 pandemic Open
Aims COVID-19 has negatively influenced oesophago-gastric (OG) cancer prognosis with stage migration described during the first six months of the pandemic. This study investigated the medium term effect of the national lockdown on diagnosi…
View article: Are CT-Derived Muscle Measurements Prognostic, Independ-ent of Systemic Inflammation, in Good Performance Status Pa-tients with Advanced Cancer?
Are CT-Derived Muscle Measurements Prognostic, Independ-ent of Systemic Inflammation, in Good Performance Status Pa-tients with Advanced Cancer? Open
The present study examined the relationships between CT-derived muscle measurements, systemic inflammation, and survival in advanced cancer patients with good performance status (ECOG-PS 0/1). Data was collected prospectively from patients…
View article: The relationship between heart rate variability and TNM stage, co-morbidity, systemic inflammation and survival in patients with primary operable colorectal cancer
The relationship between heart rate variability and TNM stage, co-morbidity, systemic inflammation and survival in patients with primary operable colorectal cancer Open
High vagal nerve activity, reliability measured by HRV, is considered protective in cancer, reducing oxidative stress, inflammation and opposing sympathetic nerve activity. The present monocentric study examines the relationship between HR…
View article: The relationship between micronutrient status, frailty, systemic inflammation, and clinical outcomes in patients admitted to hospital with COVID-19
The relationship between micronutrient status, frailty, systemic inflammation, and clinical outcomes in patients admitted to hospital with COVID-19 Open
Background Micronutrients have been associated with disease severity and poorer clinical outcomes in patients with COVID-19. However, there is a paucity of studies examining if the relationship with micronutrient status and clinical outcom…
View article: The relationship between the modified frailty index score (mFI-5), malnutrition, body composition, systemic inflammation and short-term clinical outcomes in patients undergoing surgery for colorectal cancer
The relationship between the modified frailty index score (mFI-5), malnutrition, body composition, systemic inflammation and short-term clinical outcomes in patients undergoing surgery for colorectal cancer Open
Background While the current literature suggests an association with frailty and clinical outcomes in patients undergoing surgery for colorectal cancer (CRC), the basis of this relationship is unclear. Aim Examine the relationship between …
View article: Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer
Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer Open
View article: The relationship between computed tomography‐derived sarcopenia, cardiopulmonary exercise testing performance, systemic inflammation, and survival in good performance status patients with oesophago‐gastric cancer undergoing neoadjuvant treatment
The relationship between computed tomography‐derived sarcopenia, cardiopulmonary exercise testing performance, systemic inflammation, and survival in good performance status patients with oesophago‐gastric cancer undergoing neoadjuvant treatment Open
Background Thought to capture the nutritional and functional reserve of the cancer patient, whether the computed tomography (CT)‐derived sarcopenia score (CT‐SS) has complimentary prognostic value to commonly utilized pre‐treatment host as…
View article: Inflammation and Performance Status: The Cornerstones of Prognosis in Advanced Cancer
Inflammation and Performance Status: The Cornerstones of Prognosis in Advanced Cancer Open
View article: A comparison of CT-body composition measurements in non-cancer and cancer patients from a single UK centre
A comparison of CT-body composition measurements in non-cancer and cancer patients from a single UK centre Open
In conclusion, the prevalence of a low SMI and low SMD was similar in non-cancer and cancer cohorts in our institution.
View article: The combination of computed tomography‐derived muscle mass and muscle density and relationship with clinicopathological characteristics and survival in patients undergoing potentially curative surgery for colorectal cancer
The combination of computed tomography‐derived muscle mass and muscle density and relationship with clinicopathological characteristics and survival in patients undergoing potentially curative surgery for colorectal cancer Open
Background Sarcopenia has been defined as a loss of muscle mass and function. CT‐derived muscle measurements, skeletal muscle index (SMI) and density (SMD), taken together may provide an objective measure of sarcopenia. The aim of the pres…
View article: Relationship between BMI, CT-derived body composition and colorectal neoplasia in a bowel screening population
Relationship between BMI, CT-derived body composition and colorectal neoplasia in a bowel screening population Open
Introduction Obesity is associated with an increased risk of colorectal cancer (CRC). Unlike the indirect measures such as BMI, CT-Body composition (CT-BC) allows for the assessment of both volume and distribution of adipose tissue. Theref…
View article: Cancer cachexia: a nutritional or a systemic inflammatory syndrome?
Cancer cachexia: a nutritional or a systemic inflammatory syndrome? Open
View article: The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review
The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review Open
Introduction Frailty is a complex multifactorial syndrome characterised by a significant increase in vulnerability and worsened health outcomes. Despite a range of proposed frailty screening measures, the prevalence and prognostic value of…
View article: The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19
The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19 Open
Background Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality in patients with COVID-19. However, the relationship between frailty a…