Josh Richards
YOU?
Author Swipe
View article: Radiometric and safety assessment of a ‘low‐level red‐light’ myopia control device
Radiometric and safety assessment of a ‘low‐level red‐light’ myopia control device Open
Purpose Recent literature has demonstrated that ‘low‐level red‐light therapy’ may be effective at slowing axial elongation in children, but reports have questioned the safety of some red‐light devices. The current work explored the beam ch…
View article: Optical characterisation and vision quality assessment of two myopia control contact lenses
Optical characterisation and vision quality assessment of two myopia control contact lenses Open
Purpose This investigation examined the image and vision quality of two commercially available daily disposable myopia control soft contact lenses. Methods Wavefront errors were measured with an SHS Ophthalmic aberrometer for two myopia co…
View article: Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection
Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection Open
The murine intestinal nematode Heligmosomoides polygyrus bakeri (Hpb) modulates the host immune response via the Hpb alarmin release inhibitor (HpARI) family (HpARI1/2/3), which acts on interleukin (IL)-33, and the Hpb binds alarmin recept…
View article: Vaccination against helminth IL-33-modulators permits immune-mediated parasite ejection
Vaccination against helminth IL-33-modulators permits immune-mediated parasite ejection Open
The murine intestinal nematode Heligmosomoides polygyrus bakeri powerfully modulates the host immune response. This is achieved in part through the HpARI family (HpARI1/2/3), which act on IL-33, and the HpBARI family (HpBARI and HpBARI_Hom…
View article: The association between participant‐reported ratings of comfort, dryness and vision quality in soft contact lens wearers
The association between participant‐reported ratings of comfort, dryness and vision quality in soft contact lens wearers Open
Introduction Previous literature has indicated an association between participant‐reported perceptions (e.g., ratings) of comfort, dryness and vision quality during soft contact lens wear. However, these reports do not account for particip…
View article: Digital device viewing behaviour in children
Digital device viewing behaviour in children Open
Introduction Habitual viewing behaviour is widely believed to be an important contributing factor to the onset and progression of myopia and may be task dependent. The purpose of this study was to quantify the habitual viewing distance of …
View article: On‐eye centration of soft contact lenses
On‐eye centration of soft contact lenses Open
Purpose To evaluate the relative positions of modern soft contact lenses (SCLs) relative to the limbus/cornea and the pupil. Methods Sixty images of the anterior eyes of 101 subjects were acquired over 10 s while participants fixated the c…
View article: Inserting “OFF-to-ON” BODIPY Tags into Cytokines: A Fluorogenic Interleukin IL-33 for Real-Time Imaging of Immune Cells
Inserting “OFF-to-ON” BODIPY Tags into Cytokines: A Fluorogenic Interleukin IL-33 for Real-Time Imaging of Immune Cells Open
The essential functions that cytokine/immune cell interactions play in tissue homeostasis and during disease have prompted the molecular design of targeted fluorophores to monitor their activity in real time. Whereas activatable probes for…
View article: Characteristics of ‘super responders’ and ‘super nonresponders’ to first biologic monotherapy for psoriasis: a nested case–control study
Characteristics of ‘super responders’ and ‘super nonresponders’ to first biologic monotherapy for psoriasis: a nested case–control study Open
It is unknown why some patients with psoriasis experience long-term effectiveness with their first biologic monotherapy. Our aim was to compare the baseline demographic, disease, genotypic, clinical and lifestyle characteristics of patient…
View article: Drug Survival Associated With Effectiveness and Safety of Treatment With Guselkumab, Ixekizumab, Secukinumab, Ustekinumab, and Adalimumab in Patients With Psoriasis
Drug Survival Associated With Effectiveness and Safety of Treatment With Guselkumab, Ixekizumab, Secukinumab, Ustekinumab, and Adalimumab in Patients With Psoriasis Open
Importance Drug survival of biologic therapies for psoriasis is a proxy for longer-term treatment effectiveness and safety. Patient factors that are associated with the survival of each biologic differently (effect modifiers) may inform th…
View article: Suppression of airway allergic eosinophilia by <scp><i>Hp</i>‐TGM</scp>, a helminth mimic of <scp>TGF</scp>‐β
Suppression of airway allergic eosinophilia by <span><i>Hp</i>‐TGM</span>, a helminth mimic of <span>TGF</span>‐β Open
Type 2‐high asthma is a chronic inflammatory disease of the airways which is increasingly prevalent in countries where helminth parasite infections are rare, and characterized by T helper 2 (Th2)‐dependent accumulation of eosinophils in th…
View article: Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis
Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis Open
The identification of robust endotypes-disease subgroups of clinical relevance-is fundamental to stratified medicine. We hypothesized that HLA-C∗06:02 status, the major genetic determinant of psoriasis, defines a psoriasis endotype of clin…
View article: A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine
A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine Open
The murine intestinal nematode Heligmosomoides polygyrus releases the H. polygyrus Alarmin Release Inhibitor (HpARI) - a protein which binds to IL-33 and to DNA, effectively tethering the cytokine in the nucleus of necrotic cells. Previous…
View article: A truncated form of HpARI stabilises IL-33, amplifying responses to the cytokine
A truncated form of HpARI stabilises IL-33, amplifying responses to the cytokine Open
1 Abstract The murine intestinal nematode Heligmosomoides polygyrus releases the H. polygyrus Alarmin Release Inhibitor (HpARI) - a protein which binds to IL-33 and to DNA, effectively tethering the cytokine in the nucleus of necrotic cell…