Josh Yuan
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View article: A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys
A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys Open
Ectoenzyme CD38 is increased on lymphocytes in response to an antigenic challenge and it is hypothesized that targeting these activated lymphocytes could ameliorate pathologic activities in autoimmune diseases. The cynomolgus monkey is an …
View article: Pharmacokinetics and pharmacodynamics of the cytolytic anti‐<scp>CD</scp>38 human monoclonal antibody <scp>TAK</scp>‐079 in monkey – model assisted preparation for the first in human trial
Pharmacokinetics and pharmacodynamics of the cytolytic anti‐<span>CD</span>38 human monoclonal antibody <span>TAK</span>‐079 in monkey – model assisted preparation for the first in human trial Open
We are studying the fully human, IgG1λ cytolytic monoclonal antibody TAK ‐079, which binds CD 38. CD 38 is expressed on plasma and natural killer ( NK ) cells constitutively and upregulated on subsets of B and T lymphocytes upon activation…
View article: A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance Open