Joshi M. Ramanjulu
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View article: Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics
Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics Open
Drugs targeting the ER-resident innate immune receptor Stimulator of Interferon Genes (STING) are in development for treatments of cancer and inflammatory diseases. Accurate determination of STING receptor levels in normal and disease tiss…
View article: Alternative cGAS signaling promotes herpes simplex encephalitis
Alternative cGAS signaling promotes herpes simplex encephalitis Open
During infection, foreign DNA is sensed by cyclic GMP-AMP synthase (cGAS) leading to the production of cGAMP, STING-dependent type I interferon and proinflammatory cytokine expression, and autophagy. To prevent a response to self-DNA, cGAS…
View article: STING Orchestrates EV-D68 Replication and Immunometabolism within Viral-Induced Replication Organelles
STING Orchestrates EV-D68 Replication and Immunometabolism within Viral-Induced Replication Organelles Open
Some respiratory viruses, such as Human Rhinovirus, SARS-CoV-2, and Enterovirus D-68 (EV-D68), share the feature of hijacking host lipids in order to generate specialised replication organelles (ROs) with unique lipid compositions to enabl…
View article: STING Agonist Induced Innate Immune Responses Drive Anti-Respiratory Virus Activity <i>In Vitro</i> with Limited Antiviral Efficacy <i>In Vivo</i>
STING Agonist Induced Innate Immune Responses Drive Anti-Respiratory Virus Activity <i>In Vitro</i> with Limited Antiviral Efficacy <i>In Vivo</i> Open
The emergence of SARS-CoV-2 and seasonal outbreaks of other respiratory viruses highlight the urgent need for broad-spectrum antivirals to treat respiratory tract infections. Stimulator of interferon genes (STING) is a key component of inn…
View article: Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication Open
Human rhinovirus (HRV), like coronavirus (HCoV), are positive-strand RNA viruses that cause both upper and lower respiratory tract illness, with their replication facilitated by concentrating RNA-synthesizing machinery in intracellular com…
View article: Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction
Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction Open
[Image: see text] The pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, phase II enzymes, and multidrug efflux pumps. Theref…
View article: A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection Open
Pharmacological activation of STING protects against SARS-CoV-2 infection.
View article: In vitro demonstration of a potential role for STING agonist in HIV cure
In vitro demonstration of a potential role for STING agonist in HIV cure Open
View article: Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity
Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity Open
View article: Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor
Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor Open
The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and neuroinf…
View article: MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses
MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses Open
CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this complex, MALT1 functions as both a scaffolding protein to activate NF-κB through rec…