Joshua A. Adkinson
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View article: Neural signatures and personalized neuromodulation in a subject experiencing context-dependent inhibitory control deficits
Neural signatures and personalized neuromodulation in a subject experiencing context-dependent inhibitory control deficits Open
The ability to override prepotent actions is critical to control impulses and adjust behavior depending on goals and contextual needs. In this study, we investigate the inhibitory control abilities of a patient diagnosed with Klüver-Bucy S…
View article: Author Correction: Beta activity in human anterior cingulate cortex mediates reward biases
Author Correction: Beta activity in human anterior cingulate cortex mediates reward biases Open
View article: Asymmetric Cingulum Bundle Connectivity Is Modulated by Paracingulate Sulcus Morphology
Asymmetric Cingulum Bundle Connectivity Is Modulated by Paracingulate Sulcus Morphology Open
The cingulum bundle (CB) is a group of axons supporting connectivity among several functional brain networks relevant in healthy and diseased states. The paracingulate sulcus (PCS) is present in at least one cerebral hemisphere across 70% …
View article: Neural signatures and personalized neuromodulation in a subject experiencing context-dependent inhibitory control deficits
Neural signatures and personalized neuromodulation in a subject experiencing context-dependent inhibitory control deficits Open
The ability to override prepotent actions is critical to control impulses and adjust behavior depending on goals and contextual needs. In this study, we investigate the inhibitory control abilities of a patient diagnosed with Klüver-Bucy S…
View article: Learning and language in the unconscious human hippocampus
Learning and language in the unconscious human hippocampus Open
Consciousness is a fundamental component of cognition, 1 but the degree to which higher-order perception relies on it remains disputed. 2,3 Here we demonstrate the persistence of learning, semantic processing, and online prediction in indi…
View article: Independent Continuous Tracking of Multiple Agents in the Human Hippocampus
Independent Continuous Tracking of Multiple Agents in the Human Hippocampus Open
The pursuit of fleeing prey is a core element of many species behavioral repertoires. It poses the difficult problem of continuous tracking of multiple agents, including both self and others. To understand how this tracking is implemented …
View article: Tuning Evoked Responses: A Nonlinear Relationship with Pulse Width Across Charge-Equivalent Stimulation in the Dorsal Anterior Cingulate Cortex
Tuning Evoked Responses: A Nonlinear Relationship with Pulse Width Across Charge-Equivalent Stimulation in the Dorsal Anterior Cingulate Cortex Open
View article: Proper reference selection and re-referencing to mitigate bias in single pulse electrical stimulation data
Proper reference selection and re-referencing to mitigate bias in single pulse electrical stimulation data Open
Single pulse electrical stimulation experiments produce pulse-evoked potentials used to infer brain connectivity. The choice of recording reference for intracranial electrodes remains non-standardized and can significantly impact data inte…
View article: Towards objective, temporally resolved neurobehavioral predictors of emotional state
Towards objective, temporally resolved neurobehavioral predictors of emotional state Open
View article: Intracranial Directed Connectivity Links Subregions of the Prefrontal Cortex to Major Depression
Intracranial Directed Connectivity Links Subregions of the Prefrontal Cortex to Major Depression Open
Understanding the neural basis of major depressive disorder (MDD) is vital to guiding neuromodulatory treatments. The available evidence supports the hypothesis that MDD is fundamentally a disease of cortical disinhibition, where breakdown…
View article: Beta activity in human anterior cingulate cortex mediates reward biases
Beta activity in human anterior cingulate cortex mediates reward biases Open
The rewards that we get from our choices and actions can have a major influence on our future behavior. Understanding how reward biasing of behavior is implemented in the brain is important for many reasons, including the fact that diminut…
View article: Default mode network electrophysiological dynamics and causal role in creative thinking
Default mode network electrophysiological dynamics and causal role in creative thinking Open
The default mode network (DMN) is a widely distributed, intrinsic brain network thought to play a crucial role in internally directed cognition. The present study employs stereo-EEG in 13 human patients, obtaining high resolution neural re…
View article: Insula uses overlapping codes for emotion in self and others
Insula uses overlapping codes for emotion in self and others Open
SUMMARY In daily life, we must recognize others’ emotions so we can respond appropriately. This ability may rely, at least in part, on neural responses similar to those associated with our own emotions. We hypothesized that the insula, a c…
View article: Brain mechanisms underlying the emotion processing bias in treatment-resistant depression
Brain mechanisms underlying the emotion processing bias in treatment-resistant depression Open
View article: Stereo-Electroencephalography–Guided Network Neuromodulation for Psychiatric Disorders: The Neurophysiology Monitoring Unit
Stereo-Electroencephalography–Guided Network Neuromodulation for Psychiatric Disorders: The Neurophysiology Monitoring Unit Open
BACKGROUND AND OBJECTIVES: Recent advances in stereotactic and functional neurosurgery have brought forth the stereo-electroencephalography approach which allows deeper interrogation and characterization of the contributions of deep struct…
View article: A biophysically constrained brain connectivity model based on stimulation-evoked potentials.
A biophysically constrained brain connectivity model based on stimulation-evoked potentials. Open
View article: Prefrontal network engagement by deep brain stimulation in limbic hubs
Prefrontal network engagement by deep brain stimulation in limbic hubs Open
Prefrontal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these circuits are being used with increasing frequency to treat a host of …
View article: A biophysically constrained brain connectivity model based on stimulation-evoked potentials
A biophysically constrained brain connectivity model based on stimulation-evoked potentials Open
Background Single-pulse electrical stimulation (SPES) is an established technique used to map functional effective connectivity networks in treatment-refractory epilepsy patients undergoing intracranial-electroencephalography monitoring. W…
View article: Stereo-EEG-guided network modulation for psychiatric disorders: Surgical considerations
Stereo-EEG-guided network modulation for psychiatric disorders: Surgical considerations Open
This novel hybrid sEEG-DBS approach allows detailed study of the neurophysiological substrates of complex neuropsychiatric disorders.
View article: Brain mechanisms underlying the emotion processing bias in treatment-resistant depression
Brain mechanisms underlying the emotion processing bias in treatment-resistant depression Open
Depression is associated with a cognitive bias towards negative information and away from positive information. This biased emotion processing may underlie core depression symptoms, including persistent feelings of sadness or low mood and …
View article: Intracranial stimulation and EEG feature analysis reveal affective salience network specialization
Intracranial stimulation and EEG feature analysis reveal affective salience network specialization Open
Emotion is represented in limbic and prefrontal brain areas, herein termed the affective salience network (ASN). Within the ASN, there are substantial unknowns about how valence and emotional intensity are processed—specifically, which nod…
View article: Decoding Depression Severity From Intracranial Neural Activity
Decoding Depression Severity From Intracranial Neural Activity Open
View article: Intracranial electrophysiology helps define pathological networks and optimize stimulation approaches in deep brain stimulation for treatment-resistant depression
Intracranial electrophysiology helps define pathological networks and optimize stimulation approaches in deep brain stimulation for treatment-resistant depression Open
Background: Deep brain stimulation for TRD faces critical unknowns, including defining the modulated brain network, and characterizing response patterns to optimize stimulation parameter selection. In a novel experimental setting – patient…
View article: Prefrontal network engagement by deep brain stimulation in limbic hubs
Prefrontal network engagement by deep brain stimulation in limbic hubs Open
Background Prefrontal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these circuits are being used with increasing frequency to treat…
View article: Automated optimization of deep brain stimulation parameters for modulating neuroimaging-based targets
Automated optimization of deep brain stimulation parameters for modulating neuroimaging-based targets Open
Objective. Therapeutic efficacy of deep brain stimulation (DBS) in both established and emerging indications, is highly dependent on accurate lead placement and optimized clinical programming. The latter relies on clinicians’ experience to…
View article: Automated optimization of deep brain stimulation parameters for modulating neuroimaging-based targets
Automated optimization of deep brain stimulation parameters for modulating neuroimaging-based targets Open
Objective Therapeutic efficacy of deep brain stimulation (DBS) in both established and emerging indications, is highly dependent on accurate lead placement and optimized clinical programming. The latter relies on clinicians’ experience to …
View article: Decoding Depression Severity from Intracranial Neural Activity
Decoding Depression Severity from Intracranial Neural Activity Open
Disorders of mood and cognition are prevalent, disabling, and notoriously difficult to treat. Fueling this challenge in treatment is a significant gap in our understanding of their neurophysiological basis. Here, we used intracranial neura…
View article: Imaging versus electrographic connectivity in human mood-related fronto-temporal networks
Imaging versus electrographic connectivity in human mood-related fronto-temporal networks Open
View article: Deep Brain Stimulation for Depression Informed by Intracranial Recordings
Deep Brain Stimulation for Depression Informed by Intracranial Recordings Open
View article: NeuroDAC: an open-source arbitrary biosignal waveform generator
NeuroDAC: an open-source arbitrary biosignal waveform generator Open
Objective. Researchers are developing biomedical devices with embedded closed-loop algorithms for providing advanced adaptive therapies. As these devices become more capable and algorithms become more complex, tasked with integrating and i…