Joshua A. Owens
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View article: A high fiber diet or supplementation with <i>Lactococcus lactis</i> subspecies cremoris to pregnant mice confers protection against intestinal injury in adult offspring
A high fiber diet or supplementation with <i>Lactococcus lactis</i> subspecies cremoris to pregnant mice confers protection against intestinal injury in adult offspring Open
The diet during pregnancy, or antenatal diet, influences the offspring's intestinal health. We previously showed that antenatal butyrate supplementation reduces injury in adult murine offspring with dextran sulfate sodium (DSS)-induced col…
View article: Deleterious variants in TNFAIP3 are associated with type II and seronegative pediatric autoimmune hepatitis
Deleterious variants in TNFAIP3 are associated with type II and seronegative pediatric autoimmune hepatitis Open
View article: Microbial metabolite delta-valerobetaine is a diet-dependent obesogen
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen Open
View article: <i>Lactococcus lactis sb. cremoris</i> orchestrates signal events in the gut epithelium via TLR2 to promote tissue restitution
<i>Lactococcus lactis sb. cremoris</i> orchestrates signal events in the gut epithelium via TLR2 to promote tissue restitution Open
The use of beneficial bacteria to promote gastrointestinal heath is widely practiced, however, the mechanisms whereby many of these microbes elicit their beneficial effects remain elusive. Previously, we conducted a screen for the discover…
View article: Corrigendum to: Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies
Corrigendum to: Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies Open
View article: Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies
Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies Open
We have demonstrated that neuropeptide Y (NPY) can regulate pro-inflammatory signaling in the gut via cross-talk with the pro-inflammatory cytokine tumor necrosis factor (TNF). Here, we investigated if selective blocking of NPY receptors, …
View article: Butyrate supplementation to pregnant mice elicits cytoprotection against colonic injury in the offspring
Butyrate supplementation to pregnant mice elicits cytoprotection against colonic injury in the offspring Open
View article: Are We Forgetting About IgA? A Re‐examination of Coronavirus Disease 2019 Convalescent Plasma
Are We Forgetting About IgA? A Re‐examination of Coronavirus Disease 2019 Convalescent Plasma Open
Background While convalescent plasma (CP) may benefit patients with COVID‐19, fundamental questions remain regarding its efficacy, including the components of CP that may contribute to its therapeutic effect. Most current serological evalu…
View article: Comparison of Antibody Class-Specific SARS-CoV-2 Serologies for the Diagnosis of Acute COVID-19
Comparison of Antibody Class-Specific SARS-CoV-2 Serologies for the Diagnosis of Acute COVID-19 Open
Accurate diagnosis of acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical for appropriate management of patients with this disease. We examined the possible complementary role of laboratory-developed cl…
View article: Lactobacillus rhamnosus GG Orchestrates an Antitumor Immune Response
Lactobacillus rhamnosus GG Orchestrates an Antitumor Immune Response Open
View article: At the heart of microbial conversations: endocannabinoids and the microbiome in cardiometabolic risk
At the heart of microbial conversations: endocannabinoids and the microbiome in cardiometabolic risk Open
Cardiometabolic syndrome encompasses intertwined risk factors such as hypertension, dyslipidemia, elevated triglycerides, abdominal obesity, and other maladaptive metabolic and inflammatory aberrations. As the molecular mechanisms linking …
View article: Serum pooling for rapid expansion of anti-SARS-CoV-2 antibody testing capacity
Serum pooling for rapid expansion of anti-SARS-CoV-2 antibody testing capacity Open
These results suggest that pooling strategies may allow expansion of serological testing capacity. While limitations exist, such strategies may aid in large-scale epidemiological screening or identification of optimal convalescent plasma d…
View article: Galectin-9 Is a Novel Regulator of Epithelial Restitution
Galectin-9 Is a Novel Regulator of Epithelial Restitution Open
View article: Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury
Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury Open
View article: Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis
Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis Open
View article: Neutrophil-Derived Reactive Oxygen Orchestrates Epithelial Cell Signaling Events during Intestinal Repair
Neutrophil-Derived Reactive Oxygen Orchestrates Epithelial Cell Signaling Events during Intestinal Repair Open
View article: Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine
Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine Open
The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such claims remains limited. We address this gap by identifying a beneficial bacteriu…
View article: Gut Resident <i>Lactobacilli</i> Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury
Gut Resident <i>Lactobacilli</i> Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury Open
View article: The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression Open