Joshua Beale
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View article: Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia
Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia Open
During cancer development, mutations promote gene expression changes that cause transformation. Leukemia is frequently associated with aberrant HOXA expression driven by translocations in nucleoporin genes or KMT2A, and mutations in NPM1. …