Joshua Blight
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View article: Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo
Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo Open
Infectious diseases continue to pose a substantial burden on global populations, requiring innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed modular synthetic polymer nanoparticles that mimic functio…
View article: An Extracellular Redox Signal Triggers Calcium Release and Impacts the Asexual Development of Toxoplasma gondii
An Extracellular Redox Signal Triggers Calcium Release and Impacts the Asexual Development of Toxoplasma gondii Open
The ability of an organism to sense and respond to environmental redox fluctuations relies on a signaling network that is incompletely understood in apicomplexan parasites such as Toxoplasma gondii . The impact of changes in redox upon the…
View article: Dissection-independent production of<i>Plasmodium</i>sporozoites from whole mosquitoes
Dissection-independent production of<i>Plasmodium</i>sporozoites from whole mosquitoes Open
Progress towards a protective vaccine against malaria remains slow. To date, only limited protection has been routinely achieved following immunisation with either whole-parasite (sporozoite) or subunit-based vaccines. One major roadblock …
View article: Detection of Plasmodium Falciparum in Laboratory and Naturally Infected Mosquitoes Using Near-infrared Spectroscopy
Detection of Plasmodium Falciparum in Laboratory and Naturally Infected Mosquitoes Using Near-infrared Spectroscopy Open
There is an urgent need for high throughput, affordable methods of detecting pathogens inside insect vectors to facilitate surveillance. Near-infrared spectroscopy (NIRS) has shown promise to detect arbovirus and malaria in the laboratory …
View article: An extracellular redox signal triggers calcium release and impacts the asexual development of<i>Toxoplasma gondii</i>
An extracellular redox signal triggers calcium release and impacts the asexual development of<i>Toxoplasma gondii</i> Open
The ability of an organism to sense and respond to environmental redox fluctuations relies on a signaling network that is incompletely understood in apicomplexan parasites such as Toxoplasma gondii . The impact of changes in redox upon the…
View article: A single-cell atlas of <i>Plasmodium falciparum</i> transmission through the mosquito
A single-cell atlas of <i>Plasmodium falciparum</i> transmission through the mosquito Open
Malaria parasites have a complex life cycle featuring diverse developmental strategies, each uniquely adapted to navigate specific host environments. Here we use single-cell transcriptomics to illuminate gene usage across the transmission …
View article: Dissection-independent production of a protective whole-sporozoite malaria vaccine
Dissection-independent production of a protective whole-sporozoite malaria vaccine Open
Complete protection against human malaria challenge has been achieved using infected mosquitoes as the delivery route for immunization with Plasmodium parasites. Strategies seeking to replicate this efficacy with either a manufactured whol…
View article: Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Salmonella Serovars
Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Salmonella Serovars Open
Salmonella enterica infections remain a challenging health issue, causing significant morbidity and mortality worldwide. Current vaccines against typhoid fever display moderate efficacy whilst no licensed vaccines are available for paratyp…
View article: Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention
Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention Open
Over three billion are at risk of dengue infection with more than 100 million a year presenting with symptoms that can lead to deadly haemorrhagic disease. There are however no treatments available and the only licensed vaccine shows limit…
View article: Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus
Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus Open
Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term…
View article: Tailoring a Plasmodium vivax Vaccine To Enhance Efficacy through a Combination of a CSP Virus-Like Particle and TRAP Viral Vectors
Tailoring a Plasmodium vivax Vaccine To Enhance Efficacy through a Combination of a CSP Virus-Like Particle and TRAP Viral Vectors Open
Vivax malaria remains one of the most serious and neglected tropical diseases, with 132 to 391 million clinical cases per year and 2.5 billion people at risk of infection. A vaccine against Plasmodium vivax could have more impact than any …
View article: Tailoring a P. vivax vaccine to enhance efficacy through a combination of a CSP Virus-Like Particle Rv21 and TRAP viral vectors.
Tailoring a P. vivax vaccine to enhance efficacy through a combination of a CSP Virus-Like Particle Rv21 and TRAP viral vectors. Open
Vivax malaria remains one of the most serious and neglected tropical diseases, with 132 to 391 million clinical cases per year and 2.5 billion people at risk of infection. A vaccine against Plasmodium vivax could have more impact than any …
View article: Intervention methods against mosquito-borne diseases
Intervention methods against mosquito-borne diseases Open
Mosquito-borne diseases account for hundreds of thousands of deaths each year, highlighting the need for successful intervention methods, which can be targeted at either the pathogen, mosquito vector, or human host. This thesis aims to con…