Joshua Brown-Clay
YOU?
Author Swipe
View article: Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus
Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus Open
The actin cytoskeleton plays a critical role in cancer cell invasion and metastasis; however, the coordination of its multiple functions remains unclear. Actin dynamics in the cytoplasm control the formation of invadopodia, which are membr…
View article: Supplementary Materials and Methods from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Materials and Methods from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Supplementary Materials and Methods
View article: Supplementary Movie S2. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Movie S2. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Typical actin cytoskeleton organization observed in most NK cell-conjugated MCF-7 cells. The cell conjugate was acquired on a LSM880 laser scanning confocal microscope (Carl Zeiss) with Airyscan in the high-resolution mode, and the 3D proj…
View article: Supplementary Figures S1-S6 from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Figures S1-S6 from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Supplementary Figures S1-S6 and their legends
View article: Data from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Data from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskel…
View article: Data from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Data from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskel…
View article: Supplementary Materials and Methods from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Materials and Methods from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Supplementary Materials and Methods
View article: Supplementary Figures S1-S6 from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Figures S1-S6 from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Supplementary Figures S1-S6 and their legends
View article: Supplementary Movie S3. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Movie S3. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Time lapse imaging movie showing typical actin cytoskeleton configurations and dynamics in MDA-MB-231 cells upon NK cell attack. Individual Z stacks were taken every minute over a period of 2 hours. Time lapse movies were assembled from th…
View article: Supplementary Movie S1. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Movie S1. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Typical actin cytoskeleton organization observed in most NK cell-conjugated MDA-MB-231 cells. The cell conjugate was acquired on a LSM880 laser scanning confocal microscope (Carl Zeiss) with Airyscan in the high-resolution mode, and the 3D…
View article: Supplementary Movie S3. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Movie S3. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Time lapse imaging movie showing typical actin cytoskeleton configurations and dynamics in MDA-MB-231 cells upon NK cell attack. Individual Z stacks were taken every minute over a period of 2 hours. Time lapse movies were assembled from th…
View article: Supplementary Movie S4. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Movie S4. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Time lapse imaging movie showing typical actin cytoskeleton configurations and dynamics in MCF-7 cells upon NK cell attack. Individual Z stacks were taken every minute over a period of 77 minutes. Time lapse movies were assembled from the …
View article: Supplementary Movie S1. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Movie S1. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Typical actin cytoskeleton organization observed in most NK cell-conjugated MDA-MB-231 cells. The cell conjugate was acquired on a LSM880 laser scanning confocal microscope (Carl Zeiss) with Airyscan in the high-resolution mode, and the 3D…
View article: Supplementary Movie S2. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Movie S2. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Typical actin cytoskeleton organization observed in most NK cell-conjugated MCF-7 cells. The cell conjugate was acquired on a LSM880 laser scanning confocal microscope (Carl Zeiss) with Airyscan in the high-resolution mode, and the 3D proj…
View article: Supplementary Movie S4. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Supplementary Movie S4. from Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Time lapse imaging movie showing typical actin cytoskeleton configurations and dynamics in MCF-7 cells upon NK cell attack. Individual Z stacks were taken every minute over a period of 77 minutes. Time lapse movies were assembled from the …
View article: A Synthetic Small Molecule Carbazole SH-I-125 Degrades Androgen Receptor and Overcomes Castration-Resistance and Enzalutamide-Resistance in Prostate Cancer Cells
A Synthetic Small Molecule Carbazole SH-I-125 Degrades Androgen Receptor and Overcomes Castration-Resistance and Enzalutamide-Resistance in Prostate Cancer Cells Open
Resistance to clinical anti-androgens is an ongoing problem in the treatment of castration-resistant prostate cancer (CRPC). Although second generation anti-androgens demonstrate initial clinical benefit, patients often develop resistance …
View article: Pro-Metastatic Matrix Metalloproteinase Expression is Induced by the Invadopodial and Cytoskeletal Regulators Glycine- and Cysteine-Rich Proteins 1 and 2
Pro-Metastatic Matrix Metalloproteinase Expression is Induced by the Invadopodial and Cytoskeletal Regulators Glycine- and Cysteine-Rich Proteins 1 and 2 Open
View article: Aberrant expression of PDZ-binding kinase/T-LAK cell-originated protein kinase modulates the invasive ability of human pancreatic cancer cells via the stabilization of oncoprotein c-MYC
Aberrant expression of PDZ-binding kinase/T-LAK cell-originated protein kinase modulates the invasive ability of human pancreatic cancer cells via the stabilization of oncoprotein c-MYC Open
High frequency of mortality in patients with pancreatic ductal adenocarcinoma (PDAC) is vastly associated with the invasive and metastatic nature of these cancer cells. Little is known about the factors involved in this invasive/metastatic…
View article: Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity Open
Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskel…
View article: Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2
Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2 Open
View article: Erratum: PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion
Erratum: PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion Open
View article: PBK promotes aggressive behavior of prostate cancer cells through upregulation of a β-catenin/TCF/LEF- and MYC-driven pro-metastasis gene expression program
PBK promotes aggressive behavior of prostate cancer cells through upregulation of a β-catenin/TCF/LEF- and MYC-driven pro-metastasis gene expression program Open
View article: PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion
PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion Open
A current challenge in prostate cancer treatment is how to differentiate aggressive disease from indolent prostate cancer. There is an urgent need to identify markers that would accurately distinguish indolent prostate cancer from aggressi…