Jeff Johnson
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View article: Mapping of genotype-by-environment interaction loci for Metabolic Syndrome-like traits using the multi-parent Drosophila Synthetic Population Resource determines that main genetic effects are distinct from environment dependent plastic loci
Mapping of genotype-by-environment interaction loci for Metabolic Syndrome-like traits using the multi-parent Drosophila Synthetic Population Resource determines that main genetic effects are distinct from environment dependent plastic loci Open
Metabolic Syndrome (MetS) risk, driven by genotype-environment interactions like diet, is rising globally. Due to its genetic and environmental complexity, the genetic architecture and interconnected traits underlying MetS is poorly unders…
View article: Is Flash Attention Stable?
Is Flash Attention Stable? Open
Training large-scale machine learning models poses distinct system challenges, given both the size and complexity of today's workloads. Recently, many organizations training state-of-the-art Generative AI models have reported cases of inst…
View article: Supplementary Table S5 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S5 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S5. Quantification of peptides identified bound to dasatinib by mass spectrometry.
View article: Supplementary Table S5 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S5 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S5. Quantification of peptides identified bound to dasatinib by mass spectrometry.
View article: Supplementary Methods, Table Legends, Figures 1 - 7 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Methods, Table Legends, Figures 1 - 7 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Figure 1. Distribution of gene alterations in Breast TCGA and verification of expression of MCF10A cells. Supplementary Figure 2. Analysis of the MCF10A drug screen. Supplementary Figure 3. Significance of overlap between int…
View article: Supplementary Table S1 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S1 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S1. List of constructs used to generate stable cell lines.
View article: Supplementary Table S3 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S3 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S3. Chemical-genetic interaction scores derived in this study
View article: Supplementary Table S4 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S4 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S4. List of 664 cancer cell lines and sensitivity to dasatinib as determined by area under the curve (AUC) in this study.
View article: Supplementary Table S1 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S1 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S1. List of constructs used to generate stable cell lines.
View article: Supplementary Table S2 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S2 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S2. Drugs and their concentrations used in the isogenic drug screen.
View article: Supplementary Table S3 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S3 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S3. Chemical-genetic interaction scores derived in this study
View article: Supplementary Table S4 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S4 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S4. List of 664 cancer cell lines and sensitivity to dasatinib as determined by area under the curve (AUC) in this study.
View article: Data from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Data from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
There is an urgent need in oncology to link molecular aberrations in tumors with therapeutics that can be administered in a personalized fashion. One approach identifies synthetic–lethal genetic interactions or dependencies that cancer cel…
View article: Supplementary Table S2 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Table S2 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Table S2. Drugs and their concentrations used in the isogenic drug screen.
View article: Supplementary Methods, Table Legends, Figures 1 - 7 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Supplementary Methods, Table Legends, Figures 1 - 7 from Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map Open
Supplementary Figure 1. Distribution of gene alterations in Breast TCGA and verification of expression of MCF10A cells. Supplementary Figure 2. Analysis of the MCF10A drug screen. Supplementary Figure 3. Significance of overlap between int…
View article: Perceptions of Opioid Misuse in Mississippi Agricultural Communities: Focus Group Findings
Perceptions of Opioid Misuse in Mississippi Agricultural Communities: Focus Group Findings Open
Highlights There is a concern that agricultural producers could be misusing opioids to cope with stress and injuries. Focus groups were held in Mississippi to determine perceptions of opioid misuse in the agricultural community. Results fo…
View article: Allelopathic Effects of Chrysanthemoides monilifera subsp. monilifera on Lolium rigidum in Wheat Field: Implications on the Reduction of Chemical Loads in Agro-Ecosystems
Allelopathic Effects of Chrysanthemoides monilifera subsp. monilifera on Lolium rigidum in Wheat Field: Implications on the Reduction of Chemical Loads in Agro-Ecosystems Open
Weed control through allelopathic plants is a promising approach that may minimize many of negative consequences of synthetic herbicides. We have studied potential of Chrysanthemoides monilifera subsp. monilifera (boneseed) leaf extract fo…
View article: Immune Modulatory Effects of Probiotic Streptococcus thermophilus on Human Monocytes
Immune Modulatory Effects of Probiotic Streptococcus thermophilus on Human Monocytes Open
Ingesting probiotics contributes to the development of a healthy microflora in the GIT with established benefits to human health. Some of these beneficial effects may be through the modulation of the immune system. In addition, probiotics …
View article: Immune modulatory effects of probiotic<i>Streptococcus thermophilus</i>on human monocytes
Immune modulatory effects of probiotic<i>Streptococcus thermophilus</i>on human monocytes Open
Ingesting probiotics contributes to the development of a healthy microflora in the gastrointestinal tract with established benefits to human health. Some of these beneficial effects may be through modulating of the immune system and probio…
View article: A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques
A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques Open
The recurrence of new human cases of Middle East respiratory syndrome coronavirus (MERS-CoV) underscores the need for effective therapeutic countermeasures. Nonhuman primate models are considered the gold standard for preclinical evaluatio…
View article: Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells
Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells Open
Consumption of probiotics contributes to a healthy microbiome of the GIT leading to many health benefits. They also contribute to the modulation of the immune system and are becoming popular for the treatment of a number of immune and infl…
View article: Identification and Phytotoxicity Assessment of Phenolic Compounds in Chrysanthemoides monilifera subsp. monilifera (Boneseed)
Identification and Phytotoxicity Assessment of Phenolic Compounds in Chrysanthemoides monilifera subsp. monilifera (Boneseed) Open
Chrysanthemoides monilifera subsp. monilifera (boneseed), a weed of national significance in Australia, threatens indigenous species and crop production through allelopathy. We aimed to identify phenolic compounds produced by boneseed and …