Joshua C. Drake
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View article: Sex differences in voluntary running behavior between <scp>C</scp>57<scp>BL</scp>/6 and <scp>BALB</scp>/<scp>cJ</scp> mouse strains do not correspond to changes in <scp>VO</scp>2 and <scp>RER</scp>
Sex differences in voluntary running behavior between <span>C</span>57<span>BL</span>/6 and <span>BALB</span>/<span>cJ</span> mouse strains do not correspond to changes in <span>VO</span>2 and <span>RER</span> Open
Exercise adaptations are influenced by sex and genetic background, contributing to variability in metabolic and physiological responses. This study investigates sex and strain‐specific differences following voluntary wheel running exercise…
View article: Integrative physiology of skeletal muscle for maintaining cognitive health
Integrative physiology of skeletal muscle for maintaining cognitive health Open
Cognitive decline and physical impairment are often linked with ageing, contributing to declines in health span and loss of independence in older adults. Pathological cognitive decline with age is largely considered to be a brain‐centric c…
View article: Age-dependent remodeling of the sciatic proteome in 5xFAD mice can be attenuated by exercise or donepezil treatment to maintain neuromuscular function
Age-dependent remodeling of the sciatic proteome in 5xFAD mice can be attenuated by exercise or donepezil treatment to maintain neuromuscular function Open
Background: Alzheimer’s disease (AD) progresses along a continuum for years to possibly decades prior to cognitive decline and clinical diagnosis. Preclinical AD is associated with neuromuscular dysfunction. We previously characterized ear…
View article: Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism
Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism Open
Summary Metabolic flexibility, the capacity to adapt fuel utilization in response to nutrient availability, is essential for maintaining energy homeostasis and preventing metabolic disease. Here, we investigate the role of Ulk1 phosphoryla…
View article: Mammalian mitochondrial inorganic polyphosphate (polyP) and cell signaling: Crosstalk between polyP and the activity of AMPK
Mammalian mitochondrial inorganic polyphosphate (polyP) and cell signaling: Crosstalk between polyP and the activity of AMPK Open
This manuscript sheds new light on the regulation of AMPK and positions polyP as a potent regulator of mammalian cell physiology beyond mere bioenergetics, paving the road for using its metabolism as an innovative pharmacological target in…
View article: Interplay of ROS, mitochondrial quality, and exercise in aging: Potential role of spatially discrete signaling
Interplay of ROS, mitochondrial quality, and exercise in aging: Potential role of spatially discrete signaling Open
View article: Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer’s Disease Open
Alzheimer’s disease (AD) develops along a continuum that spans years prior to diagnosis. Decreased muscle function and mitochondrial respiration occur years earlier in those that develop AD; however, it is unknown what causes these periphe…
View article: Early-stage Alzheimer’s disease: are skeletal muscle and exercise the key?
Early-stage Alzheimer’s disease: are skeletal muscle and exercise the key? Open
Alzheimer’s disease (AD) is the most common form of dementia affecting approximately 6.5 million people in the United States alone. The development of AD progresses over a span of years to possibly decades before resulting in cognitive imp…
View article: Mitochondrial plasticity supports proliferative outgrowth and invasion of ovarian cancer spheroids during adhesion
Mitochondrial plasticity supports proliferative outgrowth and invasion of ovarian cancer spheroids during adhesion Open
Background Ovarian cancer cells aggregate during or after exfoliation from the primary tumor to form threedimensional spheroids. Spheroid formation provides a survival advantage during peritoneal dissemination in nutrient and oxygen-deplet…
View article: PHOSPHORYLATION OF ULK1 AT S555 IS REQUIRED FOR METABOLIC ADAPTATIONS TO CALORIC RESTRICTION
PHOSPHORYLATION OF ULK1 AT S555 IS REQUIRED FOR METABOLIC ADAPTATIONS TO CALORIC RESTRICTION Open
Unc-51 Like Autophagy Activating Kinase 1 (Ulk1) is responsible for initiating selective degradation of damaged/dysfunctional mitochondria (mitophagy) once phosphorylated at S555 in response to energetic stress. Mitophagy is integral for m…
View article: Sensing local energetics to acutely regulate mitophagy in skeletal muscle
Sensing local energetics to acutely regulate mitophagy in skeletal muscle Open
The energetic requirements of skeletal muscle to sustain movement, as during exercise, is met largely by mitochondria, which form an intricate, interconnected reticulum. Maintenance of a healthy mitochondrial reticulum is essential for ske…
View article: AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures
AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures Open
Metabolism regulates neuronal activity and modulates the occurrence of epileptic seizures. Here, using two rodent models of absence epilepsy, we show that hypoglycaemia increases the occurrence of spike-wave seizures. We then show that sel…
View article: Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle
Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle Open
Unc51 like autophagy activating kinase 1 (Ulk1), the primary autophagy regulator, has been linked to metabolic adaptation in skeletal muscle to exercise training. Here we compared the roles of Ulk1 and homologous Ulk2 in skeletal muscle in…
View article: Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy Open
Significance Here, we present unequivocal evidence of physical association of AMPK holoenzymes with mitochondrial reticulum (mitoAMPK) across multiple mouse tissues with evidence of conservation in human skeletal muscle and heart. We demon…
View article: Author Correction: Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice
Author Correction: Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice Open
View article: Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog
Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog Open
View article: Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics
Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics Open
View article: Complex II Subunit SDHD is Critical for Cell Growth and Metabolism, Which can be Partially Restored with A Synthetic Ubiquinone Analog
Complex II Subunit SDHD is Critical for Cell Growth and Metabolism, Which can be Partially Restored with A Synthetic Ubiquinone Analog Open
Background: Succinate dehydrogenase (Complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and transferring electrons from succinate to ubiquinone in the mitochon…
View article: A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTOR pathway
A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTOR pathway Open
Our understanding of the molecular mechanisms underlying adaptations to resistance exercise remains elusive despite the significant biological and clinical relevance. We developed a novel voluntary mouse weightlifting model, which elicits …
View article: Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice
Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice Open
View article: Targeting healthspan to optimally combat non-communicable disease in an aging world
Targeting healthspan to optimally combat non-communicable disease in an aging world Open
View article: Precision remodeling: how exercise improves mitochondrial quality in myofibers
Precision remodeling: how exercise improves mitochondrial quality in myofibers Open
View article: Exercise-Induced Mitophagy in Skeletal Muscle and Heart
Exercise-Induced Mitophagy in Skeletal Muscle and Heart Open
Regular exercise enhances mitochondrial function by promoting healthy mitochondrial remodeling, but the underlying mechanisms are not thoroughly understood. An emerging hypothesis suggests that, in addition to anabolic events such as mitoc…
View article: Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria
Exercise-induced mitophagy in skeletal muscle occurs in the absence of stabilization of Pink1 on mitochondria Open
Maintenance of mitochondrial quality is essential for skeletal muscle function and overall health. Exercise training elicits profound adaptations to mitochondria to improve mitochondrial quality in skeletal muscle. We have recently demonst…
View article: Voluntary running protects against neuromuscular dysfunction following hindlimb ischemia-reperfusion in mice
Voluntary running protects against neuromuscular dysfunction following hindlimb ischemia-reperfusion in mice Open
Ischemia-reperfusion (IR) due to temporary restriction of blood flow causes tissue/organ damages under various disease conditions, including stroke, myocardial infarction, trauma, and orthopedic surgery. In the limbs, IR injury to motor ne…
View article: PO-033 Mitochondria-associated Ampk mediates mitochondrial quality control in skeletal muscle
PO-033 Mitochondria-associated Ampk mediates mitochondrial quality control in skeletal muscle Open
Objective Mitochondria exist as a complex, interconnected reticulum with the degree of complexity at homeostasis varying by cell type. Declines in mitochondrial quality is a hallmark of numerous diseases and is partly maintained through th…
View article: Unclogging the garbage disposal: how exercise may improve mitochondria in ageing skeletal muscle
Unclogging the garbage disposal: how exercise may improve mitochondria in ageing skeletal muscle Open
Skeletal muscle size and functionality decline with age, a phenomenon collectively known as sarcopenia. Sarcopenia limits independence and contributes to the development of other age-related chronic diseases and metabolic inflexibility. Wh…
View article: Mitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle
Mitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle Open
View article: Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy
Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy Open
Assessment of structural and functional changes of mitochondria is vital for biomedical research as mitochondria are the power plants essential for biological processes and tissue/organ functions. Others and we have developed a novel repor…
View article: Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy Open