Explanipedia

Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy Open

Gayathri R. Ediriweera, Amal J. Sivaram, Gary Cowin, Mikayla Brown, Luke McAlary , et al. · 2024

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with extremely limited therapeutic options. One key pathological feature of ALS is the abnormal accumulation of misfolded proteins within motor neurons. Hence, …

From viral assembly to host interaction: AFM’s contributions to virology Open

Ankita Ray, Joshua D. Simpson, İrem Demir, Victor G. Gisbert, David B. Gomes , et al. · 2024

Viruses represent a diverse pool of obligate parasites that infect virtually every known organism, as such, their study is incredibly valuable for a range of fields including public health, medicine, agriculture, and ecology, and the devel…

Single-Molecule Investigation of the Binding Interface Stability of SARS-CoV-2 Variants with ACE2 Open

Ankita Ray, Trần Thị Minh Thu, Rita dos Santos Natividade, Rodrigo A. Moreira, Joshua D. Simpson , et al. · 2024

The SARS-CoV-2 pandemic spurred numerous research endeavors to comprehend the virus and mitigate its global severity. Understanding the binding interface between the virus and human receptors is pivotal to these efforts and paramount to cu…

Deciphering molecular mechanisms stabilizing the reovirus-binding complex Open

Rita dos Santos Natividade, Melanie Koehler, Priscila da Silva Figueiredo Celestino Gomes, Joshua D. Simpson, Sydni Caet Smith , et al. · 2023

Mammalian orthoreoviruses (reoviruses) serve as potential triggers of celiac disease and have oncolytic properties, making these viruses potential cancer therapeutics. Primary attachment of reovirus to host cells is mainly mediated by the …

Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus Open

Pengcheng Shang, Joshua D. Simpson, Gwen M. Taylor, Danica M. Sutherland, Olivia L. Welsh , et al. · 2023

Single-Molecule Analysis of SARS-CoV-2 Binding to C-Type Lectin Receptors Open

Joshua D. Simpson, Ankita Ray, C. Marcon, Rita dos Santos Natividade, Gol Mohammad Dorrazehi , et al. · 2023

Despite intense scrutiny throughout the pandemic, development of efficacious drugs against SARS-CoV-2 spread remains hindered. Understanding the underlying mechanisms of viral infection is fundamental for developing novel treatments. While…

Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform Open

Maria C. Arno, Joshua D. Simpson, Lewis D. Blackman, Ruairí P. Brannigan, Kristofer J. Thurecht , et al. · 2022

In this paper we a report a pH-sensitive polycarbonate conjugated with the anticancer drug camptothecin that shows enhanced drug delivery towards cancer cells.

Enhancing the delivery of SOD1 antisense oligonucleotides to the murine brain using lipid nanoparticles and image-guided focused ultrasound Open

Gayathri R. Ediriweera, Nicholas L. Fletcher, Gary Cowin, Joshua D. Simpson, Liyu Chen , et al. · 2022

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with extremely limited therapeutic options. Abnormal accumulation of misfolded and aggregated proteins in the soma of motor neurons is one of the main pathologi…

Atomic force microscopy applied to interrogate nanoscale cellular chemistry and supramolecular bond dynamics for biomedical applications Open

Joshua D. Simpson, Ankita Ray, Melanie Koehler, Danahé Mohammed, David Alsteens · 2022

Understanding biological interactions at a molecular-level grants valuable information relevant to improving medical treatments and outcomes.

Rotavirus Binding to Cell Surface Receptors Directly Recruiting α<sub>2</sub> Integrin Open

Jinsung Yang, Jeongsoo Park, Melanie Koehler, Joshua D. Simpson, Daniel Luque , et al. · 2021

Virus–Receptor Interactions In article number 2100077, David Alsteens and co-workers report that Rotavirus binding and early entry is mediated by an integrin on the cell surface. The binding is assessed by Atomic Force Microscopy, while re…

Role of the Redox State of Human Peroxiredoxin-5 on Its TLR4-Activating DAMP Function Open

Mégane A. Poncin, Pierre Van Meerbeeck, Joshua D. Simpson, André Clippe, François Tyckaert , et al. · 2021

Human peroxiredoxin-5 (PRDX5) is a unique redox-sensitive protein that plays a dual role in brain ischemia-reperfusion injury. While intracellular PRDX5 has been reported to act as a neuroprotective antioxidative enzyme by scavenging perox…

Rotavirus Binding to Cell Surface Receptors Directly Recruiting α<sub>2</sub> Integrin Open

Jinsung Yang, Jeongsoo Park, Melanie Koehler, Joshua D. Simpson, Daniel Luque , et al. · 2021

Rotavirus interactions with endogenous cell surface receptors are of fundamental interest in virology and medicine; however, the evidence of rotavirus directly binding to the receptors and the consequent dynamic behaviors are still elusive…

Cyanine-5-Driven Behaviours of Hyperbranched Polymers Designed for Therapeutic Delivery Are Cell-Type Specific and Correlated with Polar Lipid Distribution in Membranes Open

Joshua D. Simpson, Denni Currin-Ross, Gayathri R. Ediriweera, Horst Joachim Schirra, Nicholas L. Fletcher , et al. · 2021

The ability to predict the behaviour of polymeric nanomedicines can often be obfuscated by subtle modifications to the corona structure, such as incorporation of fluorophores or other entities. However, these interactions provide an intrig…

Fluorophore Selection and Incorporation Contribute to Permeation and Distribution Behaviors of Hyperbranched Polymers in Multi-Cellular Tumor Spheroids and Xenograft Tumor Models Open

Joshua D. Simpson, Patricia Monteiro, Gayathri R. Ediriweera, Amber R. Prior, Stefan Sonderegger , et al. · 2021

Improving our understanding of how design choices in materials synthesis impact biological outcomes is of critical importance in the development of nanomedicines. Here, we show that fluorophore labeling of polymer nanomedicine candidates s…

Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery Open

Gayathri R. Ediriweera, Joshua D. Simpson, Adrian V. Fuchs, T.K. Venkatachalam, Matthias Van De Walle , et al. · 2020

There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile in vivo, as well as reducing side-effects for an increased standard o…

Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio–Nano Interface Open

Joshua D. Simpson, Samuel A. Smith, Kristofer J. Thurecht, Georgina K. Such · 2019

Nanomedicine has generated significant interest as an alternative to conventional cancer therapy due to the ability for nanoparticles to tune cargo release. However, while nanoparticle technology has promised significant benefit, there are…

Targeted Nanomaterials: Overcoming Instability of Antibody‐Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies (Adv. Healthcare Mater. 16/2016) Open

Christopher B. Howard, Nicholas L. Fletcher, Zachary H. Houston, Adrian V. Fuchs, Nathan R. B. Boase , et al. · 2016

Christopher B. Howard, and co-workers report the generation of targeted nanomaterials for cancer theranostics by mixing of hyperbranched polyethylene glycol polymers with bispecific antibodies (BsAbs) on page 2055. The cover represents a f…

Targeted multimodal hyperbranched polymers for imaging and therapy of prostate cancer Open

Brian WC Tse, Amanda K. Pearce, Adrian V. Fuchs, Joshua D. Simpson, Mei-Chun Yeh , et al. · 2016

Hyperbranched polymers (HBPs) are an emerging class of promising biocompatible agents for cancer imaging and therapy. Their structure allows for conjugation with several specific functionalities. We aimed to assess imaging and therapeutic …

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