Explanipedia

Impact of guideline-concordant post-polypectomy colonoscopy surveillance on colorectal cancer incidence and mortality Open

Samir Gupta, Joshua Demb, Jiyue Qin, Ashley Earles, Mark Lamm , et al. · 2025

Follow-up concordant with post-polypectomy surveillance guidelines is associated with reduced risk of incident CRC, but impact on risk of fatal CRC requires further study. Many post-polypectomy CRC events occur early in the surveillance wi…

Racial and Ethnic Variation in Survival in Early-Onset Colorectal Cancer Open

Joshua Demb, Scarlett Lin Gomez, Alison J. Canchola, Alexander S. Qian, James D. Murphy , et al. · 2024

Importance Rates of early-onset (before 50 years of age) colorectal cancer (EOCRC) are increasing, with notable differences across racial and ethnic groups. Limited data are available on EOCRC-related mortality differences when disaggregat…

Racial disparities in colorectal cancer outcomes and access to care: a multi-cohort analysis Open

Paul Riviere, Kylie Morgan, Leah N. Deshler, Joshua Demb, Winta T. Mehtsun , et al. · 2024

Introduction Non-Hispanic Black (NHB) Americans have a higher incidence of colorectal cancer (CRC) and worse survival than non-Hispanic white (NHW) Americans, but the relative contributions of biological versus access to care remain poorly…

Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer Open

Joshua Demb, Jennifer M. Kolb, Jonathan Dounel, Cassandra Fritz, Shailesh Advani , et al. · 2024

Importance Early-onset colorectal cancer (EOCRC), defined as a diagnosis at younger than age 50 years, is increasing, and so-called red flag signs and symptoms among these individuals are often missed, leading to diagnostic delays. Improve…

Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort Open

Shailja C. Shah, M. Constanza Camargo, Mark Lamm, Ranier Bustamante, Christianne L. Roumie , et al. · 2024

PURPOSE Helicobacter pylori is the most common cause of infection-associated cancer worldwide. We aimed to evaluate the impact of H. pylori infection and treatment on colorectal cancer (CRC) incidence and mortality. PATIENTS US Veterans wh…

Time to Endoscopy or Colonoscopy Among Adults Younger Than 50 Years With Iron-Deficiency Anemia and/or Hematochezia in the VHA Open

Joshua Demb, Lin Liu, Caitlin C. Murphy, Chyke A. Doubeni, Marı́a Elena Martı́nez , et al. · 2023

Importance To date, the diagnostic test completion rate and the time to diagnostic endoscopy or colonoscopy among adults with iron-deficiency anemia (IDA) and/or hematochezia have not been well characterized. Objective To evaluate the diag…

Ascertainment of Helicobacter pylori Infection and Eradication Treatment Using a Nationwide Electronic Health Record Database Open

Shailja C. Shah, Rohan Gupta, Ranier Bustamante, Mark Lamm, Hanin Yassin , et al. · 2023

Red-flag signs and symptoms for earlier diagnosis of early-onset colorectal cancer Open

Cassandra Fritz, Ebunoluwa Otegbeye, Xiaoyu Zong, Joshua Demb, Katelin B. Nickel , et al. · 2023

Background Prompt detection of colorectal cancer (CRC) among individuals younger than age 50 years (early-onset CRC) is a clinical priority because of its alarming rise. Methods We conducted a matched case-control study of 5075 incident ea…

Risk of Incident and Fatal Colorectal Cancer After Young-Onset Adenoma Diagnosis: A National Cohort Study Open

Yas Casey, Joshua Demb, Ngozi Enwerem, Lin Liu, Christian Jackson , et al. · 2023

INTRODUCTION: Colorectal cancer (CRC) incidence and mortality rates are increasing in adults aged <50 years. Young-onset adenoma (YOA)—adenoma detected in adults younger than 50 years—may signify increased CRC risk, but this association ha…

Predictive models to assess risk of extended length of stay in adults with spinal deformity and lumbar degenerative pathology: development and internal validation Open

Ayush Arora, Joshua Demb, Daniel D. Cummins, Matthew Callahan, Aaron J. Clark , et al. · 2022

This predictive model can facilitate identification of adults at risk for eLOS following elective multilevel lumbar/thoracolumbar spinal instrumented fusions for ASD. With a fair diagnostic accuracy, the predictive calculator will ideally …

Baseline Characteristics and Longitudinal Outcomes of Traditional Serrated Adenomas: A Cohort Study Open

Mehul A. Trivedi, Suha Godil, Joshua Demb, Ashley Earles, Ranier Bustamante , et al. · 2022

COVID-19 Pandemic Had Minimal Impact on Colonoscopy Completion After Colorectal Cancer Red Flag Sign or Symptoms in US Veterans Open

Joshua Demb, Lin Liu, Ranier Bustamante, Jason A. Dominitz, Ashley Earles , et al. · 2022

Development and internal validation of predictive models to assess risk of post-acute care facility discharge in adults undergoing multi-level instrumented fusions for lumbar degenerative pathology and spinal deformity Open

Ayush Arora, Joshua Demb, Daniel D. Cummins, Vedat Deviren, Aaron J. Clark , et al. · 2022

Purpose To develop a model for factors predictive of Post-Acute Care Facility (PACF) discharge in adult patients undergoing elective multi-level (≥ 3 segments) lumbar/thoracolumbar spinal instrumented fusions. Methods The State Inpatient D…

Breast biopsy patterns and findings among older women undergoing screening mammography: The role of age and comorbidity Open

Shailesh Advani, Linn Abraham, Diana S.M. Buist, Karla Kerlikowske, Diana L. Miglioretti , et al. · 2021

Mammography adherence in relation to function-related indicators in older women Open

Dongyu Zhang, Linn Abraham, Brian L. Sprague, Tracy Onega, Shailesh Advani , et al. · 2021

Prior studies of screening mammography patterns by functional status in older women show inconsistent results. We used Breast Cancer Surveillance Consortium-Medicare linked data (1999-2014) to investigate the association of functional limi…

Increasing Colorectal Cancer Incidence Before and After Age 50: Implications for Screening Initiation and Promotion of “On-Time” Screening Open

Moo Y. Cho, David A. Siegel, Joshua Demb, Lisa C. Richardson, Samir Gupta · 2021

CRC trends suggest observed increased risks under age 50 are also present after age 50, despite prior availability of screening for this group. Recent CRC trends support initiation of screening earlier than age 50, and promotion of "on-tim…

Association of Breast Density With Breast Cancer Risk Among Women Aged 65 Years or Older by Age Group and Body Mass Index Open

Shailesh Advani, Weiwei Zhu, Joshua Demb, Brian L. Sprague, Tracy Onega , et al. · 2021

The findings suggest that breast density is associated with increased risk of invasive breast cancer among women aged 65 years or older. Breast density and life expectancy should be considered together when discussing the potential benefit…

Addition of Financial Incentives to Mailed Outreach for Promoting Colorectal Cancer Screening Open

Antonio Facciorusso, Joshua Demb, Babu P. Mohan, Samir Gupta, Siddharth Singh · 2021

Adding financial incentives appeared to be associated with a small benefit of increasing CRC screening uptake, with marginal benefits in underserved populations with adverse social determinants of health. Alternative approaches to enhancin…

A strategy for validation of variables derived from large-scale electronic health record data Open

Lin Liu, Ranier Bustamante, Ashley Earles, Joshua Demb, Karen Messer , et al. · 2021

A structured approach for prospectively developing and validating phenotyping algorithms from large-scale EHR data can be successfully implemented, and should be considered to improve the quality of "big data" research.

Function-related Indicators and Outcomes of Screening Mammography in Older Women: Evidence from the Breast Cancer Surveillance Consortium Cohort Open

Dongyu Zhang, Linn Abraham, Joshua Demb, Diana L. Miglioretti, Shailesh Advani , et al. · 2021

Background: Previous reports suggested risk of death and breast cancer varied by comorbidity and age in older women undergoing mammography. However, impacts of functional limitations remain unclear. Methods: We used data from 238,849 women…

Contents Open

B Issaka, N Enwerem, M Cho, Joshua Demb, Al Www , et al. · 2021

Realizing the Promise of Personalized Colorectal Cancer Screening in Practice Open

Joshua Demb, Samir Gupta · 2021

Time to Colonoscopy After Abnormal Stool-Based Screening and Risk for Colorectal Cancer Incidence and Mortality Open

Yazmin San Miguel, Joshua Demb, Marı́a Elena Martı́nez, Samir Gupta, Folasade P. May · 2021

Increased time to colonoscopy is associated with higher risk of CRC incidence, death, and late-stage CRC after abnormal FIT/FOBT. Interventions to improve CRC outcomes should emphasize diagnostic follow-up within 1 year of an abnormal FIT/…

An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer Open

Andrea N. Burnett‐Hartman, Jeffrey K. Lee, Joshua Demb, Samir Gupta · 2021

Young-onset colorectal cancer risk among individuals with iron-deficiency anaemia and haematochezia Open

Joshua Demb, Lin Liu, Caitlin C. Murphy, Chyke A. Doubeni, Marı́a Elena Martı́nez , et al. · 2020

Objective Young-onset colorectal cancer (YCRC) incidence is rising. Scant data exist on YCRC risk after presentation with concerning symptoms such as iron-deficiency anaemia (IDA) or haematochezia. We examined the association between IDA a…

Systematic Review of Prevalence, Risk Factors, and Risk for Metachronous Advanced Neoplasia in Patients With Young-Onset Colorectal Adenoma Open

Ngozi Enwerem, Moo Y. Cho, Joshua Demb, Ashley Earles, Karen Heskett , et al. · 2020

Optimal breast cancer screening strategies for older women: current perspectives Open

Dejana Braithwaite, Joshua Demb, Louise M. Henderson · 2020

Breast cancer is a major cause of cancer-related deaths among older women, aged 65 years or older. Screening mammography has been shown to be effective in reducing breast cancer mortality in women aged 50–74 years but not among those aged …

Abnormal Stool Blood Tests and Colorectal Cancer Mortality in a Large United States Cohort Open

Yazmin San Miguel, Joshua Demb, ME Martínez, Suman Lata Gupta, Folasade P. May · 2020

Our aim was to examine the association between fatal colorectal cancer (CRC) and time to colonoscopy among individuals who underwent diagnostic colonoscopy after abnormal stool blood test (SBT) in a cohort of United States Veterans. Method…

Risk Factors for Early-Onset Colorectal Cancer Open

Eric E. Low, Joshua Demb, Lin Liu, Ashley Earles, Ranier Bustamante , et al. · 2020

Racial and Ethnic Disparities in Colorectal Cancer Screening Pose Persistent Challenges to Health Equity Open

Joshua Demb, Samir Gupta · 2019

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