Joshua Disatham
YOU?
Author Swipe
View article: Hypoxia-Driven Histone Modifications Govern Gene Regulation for Mature Eye Lens Formation
Hypoxia-Driven Histone Modifications Govern Gene Regulation for Mature Eye Lens Formation Open
These results provide evidence that hypoxia-induced histone modifications regulate the genes required for mature lens formation and provide a framework for understanding the role of hypoxia-specific histone modifications in the regulation …
View article: Multiomic analysis implicates FOXO4 in genetic regulation of chick lens fiber cell differentiation
Multiomic analysis implicates FOXO4 in genetic regulation of chick lens fiber cell differentiation Open
View article: Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency
Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency Open
Recent advances in next-generation sequencing and data analysis have provided new gateways for identification of novel genome-wide genetic determinants governing tissue development and disease. These advances have revolutionized our unders…
View article: Patterns of Crystallin Gene Expression in Differentiation State Specific Regions of the Embryonic Chicken Lens
Patterns of Crystallin Gene Expression in Differentiation State Specific Regions of the Embryonic Chicken Lens Open
Although it is well known that lens crystallin gene expression changes during the epithelial to fiber cell transition, these data identify for the first time three distinct patterns of expression for specific subsets of crystallin genes, e…
View article: Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
View article: Additional file 12 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 12 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 12: Table S8. Differentially methylated mCG regions that are at least partially contained within open chromatin regions at A promoters and genebodies of differentially expressed genes, or B only promoters of differentially …
View article: Additional file 9 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 9 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 9: Table S5. Average change in mCG methylation level for all differentially methylated mCG regions mapped to A–D the promoters and genebodies of differentially expressed genes, or E–H only the promoters of differentially ex…
View article: Additional file 5 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 5 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 5: Table S1. Proportion of methylated cytosines that are mCG, mCHG, mCHH in each sample of lens epithelial and fiber cells.
View article: Additional file 6 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 6 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 6: Table S2. Differentially methylated mCG regions between lens epithelial and fiber cells.
View article: Additional file 16 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 16 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 16: Table S12. Pearson correlation analysis comparing gene expression changes and methylation changes within open chromatin regions. The analyses were performed on the following conditions: differentially methylated regions…
View article: Additional file 7 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 7 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 7: Table S3. Differentially expressed genes between lens epithelial cells and fiber cells. A Epithelial preferred genes (FPKM log2FC 0.4, q
View article: Additional file 8 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 8 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 8: Table S4. Enrichr outputs of GO Biological processes (A, C) and MSigDB Hallmark pathways (B, D) significantly associated with the differentially expressed genes between lens epithelial cells and fiber cells. A, B Top 200…
View article: Additional file 10 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 10 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 10: Table S6. Enrichr outputs of MSigDB Hallmark pathways (A, C, E, G) and GO biological processes (B, D, F, H) significantly associated with differentially expressed genes containing differentially methylated promoters and…
View article: Additional file 13 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 13 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 13: Table S9. Significantly enriched transcription factor binding motifs found within A hypermethylated mCG regions in promoters or genebodies of epithelial cell preferred genes, or B hypomethylated mCG regions in promoters…
View article: Additional file 15 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 15 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 15: Table S11. Genes with established lens functions or associations with cataracts that are differentially expressed and contain differentially methylated regions between lens epithelial and fiber cells.
View article: Additional file 14 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 14 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 14: Table S10. Target binding sites of enriched transcription factor binding motifs along with corresponding methylation changes and gene expression changes. Target binding sites of enriched transcription factor motifs from…
View article: Additional file 11 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Additional file 11 of Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation Open
Additional file 11: Table S7. Differentially methylated mCG regions that are at least partially contained within open chromatin regions.
View article: A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis Open
View article: Multiomic identification of genome-wide DNA binding sites and target genes identifies HIF1α as a hypoxia-dependent master regulator of lens gene expression
Multiomic identification of genome-wide DNA binding sites and target genes identifies HIF1α as a hypoxia-dependent master regulator of lens gene expression Open
View article: A Functional Map of Genomic HIF1α-DNA Complexes in The Eye Lens Revealed Through Multiomics Analysis
A Functional Map of Genomic HIF1α-DNA Complexes in The Eye Lens Revealed Through Multiomics Analysis Open
Background: During eye lens development the fetal vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life, the lens contains a decreasing oxygen gradient from the surface to the c…
View article: Additional file 5 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
Additional file 5 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis Open
Additional file 5: Table S5. HIF1α-regulated genes with associated mitochondria functions.
View article: Additional file 3 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
Additional file 3 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis Open
Additional file 3 Table S3. Gene ontologies, pathways, and select literature references for differentially expressed genes with HIF1α binding.
View article: Additional file 1 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
Additional file 1 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis Open
Additional file 1: Table S1. HIF1α binding peaks enriched by CUT&RUN and detected with MACS2 at q
View article: Additional file 2 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
Additional file 2 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis Open
Additional file 2 Table S2. Gene expression analysis via RNA-seq of DMOG-treated vs untreated primary lens cells.
View article: Additional file 4 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
Additional file 4 of A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis Open
Additional file 4: Table S4. Enriched gene ontologies and pathways associated with HIF1α-bound upregulated and downregulated genes as determined by MsigDB and Enrichr.
View article: Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a
Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a Open
View article: Hypoxia regulates lens fiber cell differentiation to form the mature transparent eye lens
Hypoxia regulates lens fiber cell differentiation to form the mature transparent eye lens Open
View article: Lens differentiation is characterized by stage-specific changes in chromatin accessibility correlating with differentiation state-specific gene expression
Lens differentiation is characterized by stage-specific changes in chromatin accessibility correlating with differentiation state-specific gene expression Open