Joshua F. Robinson
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View article: Identification of concepts of importance for the assessment of internal validity of <i>in vitro</i> toxicology studies using a modified Delphi technique
Identification of concepts of importance for the assessment of internal validity of <i>in vitro</i> toxicology studies using a modified Delphi technique Open
Context In vitro toxicity studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. INVITES-IN, a tool for assessing the internal validity of in vitro studies, is under development in a proces…
View article: An ex vivo human placental explant model for controlled exposure studies
An ex vivo human placental explant model for controlled exposure studies Open
View article: Climate Change and Reproductive Health
Climate Change and Reproductive Health Open
Climate change is a major threat to the world's population and is due to global warming from human activities that increase atmospheric greenhouse gas levels—burning fossil fuels, industry emissions, vehicular exhaust, and aerosol chlorofl…
View article: Real-time Detection of Foodborne Pathogens and Biofilm in the Food Processing Environment with Bactiscan, A Macro-scale Fluorescence Device
Real-time Detection of Foodborne Pathogens and Biofilm in the Food Processing Environment with Bactiscan, A Macro-scale Fluorescence Device Open
Food safety relies on rapid detection methods and rigorous sampling of the food processing environment and is challenged by recurrent biofilm contamination and by sublethally injured bacteria that can evade detection. Bactiscan is investig…
View article: Placental malaria induces a unique methylation profile associated with fetal growth restriction
Placental malaria induces a unique methylation profile associated with fetal growth restriction Open
Fetal growth restriction (FGR) is associated with perinatal death and adverse birth outcomes, as well as long-term complications, including increased childhood morbidity, abnormal neurodevelopment, and cardio-metabolic diseases in adulthoo…
View article: Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence
Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence Open
View article: Non-Targeted Analysis of Environmental Contaminants and Their Associations with Semen Health Factors in Men from New York City
Non-Targeted Analysis of Environmental Contaminants and Their Associations with Semen Health Factors in Men from New York City Open
Characterizing the chemical composition of semen can provide valuable insights into the exposome and environmental factors that directly affect seminal and overall health. In this study, we compared molecular profiles of 45 donated semen s…
View article: A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies
A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies Open
Context: In vitro toxicology studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. INVITES-IN, a tool for assessing the internal validity of in vitro studies, is currently under developmen…
View article: Non-Targeted Assessment of Environmental Contaminants and their Correlations with Semen Health Factors in New York City
Non-Targeted Assessment of Environmental Contaminants and their Correlations with Semen Health Factors in New York City Open
Characterizing chemical composition of semen can provide valuable insights into the exposome and environmental factors that directly affect seminal and overall health. In this study, we compared molecular profiles of 45 donated semen sampl…
View article: Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol
Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol Open
The focus on implementation of systematic review (SR) principles in chemical risk assessments (CRAs) is growing as it has the potential to advance the rigour and transparency of the CRAs. However, the SR and CRA communities use their own s…
View article: Gravidity influences distinct transcriptional profiles of maternal and fetal placental macrophages at term
Gravidity influences distinct transcriptional profiles of maternal and fetal placental macrophages at term Open
Introduction Maternal intervillous monocytes (MIMs) and fetal Hofbauer cells (HBCs) are myeloid-derived immune cells at the maternal-fetal interface. Maternal reproductive history is associated with differential risk of pregnancy complicat…
View article: Rapid identification of reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae
Rapid identification of reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae Open
View article: Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity
Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity Open
While high-throughput (HTP) assays have been proposed as platforms to rapidly assess reproductive toxicity, there is currently a lack of established assays that specifically address germline development/function and fertility. We assessed …
View article: Placental Malaria Induces a Unique Methylation Profile Associated with Fetal Growth Restriction
Placental Malaria Induces a Unique Methylation Profile Associated with Fetal Growth Restriction Open
Background Fetal growth restriction (FGR) is associated with perinatal death and adverse birth outcomes, as well as long-term complications, including increased childhood morbidity, abnormal neurodevelopment, and cardio-metabolic diseases …
View article: Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity
Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity Open
Reproduction is a functional outcome that relies on complex cellular, tissue, and organ interactions that span the developmental period to adulthood. Thus, the assessment of its disruption by environmental chemicals would benefit significa…
View article: High rates of placental inflammation among samples collected by the Multi-Omics for Mothers and Infants consortium
High rates of placental inflammation among samples collected by the Multi-Omics for Mothers and Infants consortium Open
View article: RosetteArray<sup>®</sup>Platform for Quantitative High-Throughput Screening of Human Neurodevelopmental Risk
RosetteArray<sup>®</sup>Platform for Quantitative High-Throughput Screening of Human Neurodevelopmental Risk Open
SUMMARY Neural organoids have revolutionized how human neurodevelopmental disorders (NDDs) are studied. Yet, their utility for screening complex NDD etiologies and in drug discovery is limited by a lack of scalable and quantifiable derivat…
View article: Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity
Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity Open
Reproduction is a functional outcome that relies on complex cellular, tissue, and organ interactions that span the developmental period to adulthood. Thus, the assessment of its disruption by environmental chemicals is remarkably painstaki…
View article: Morpho-Physiological and Biochemical Responses of Tomato, Lettuce, Mexican Mint, and Industrial Hemp to Different Temperature Regimes
Morpho-Physiological and Biochemical Responses of Tomato, Lettuce, Mexican Mint, and Industrial Hemp to Different Temperature Regimes Open
Temperature stress is a major abiotic factor significantly impacting crop growth, development and productivity. In this study, we investigated the effects of different growth temperatures (10°C, 22°C, and 35°C) on the morphological, physio…
View article: Protocol: Testing the Performance of INVITES-IN, A Tool for Assessing the Internal Validity of <i>In Vitro</i> Studies
Protocol: Testing the Performance of INVITES-IN, A Tool for Assessing the Internal Validity of <i>In Vitro</i> Studies Open
A tool for evaluation of internal validity of in vitro studies called INVITES-IN is currently under development. The tool is designed specifically for cell culture studies. This protocol describes the testing of the performance of…
View article: Distinct transcriptional profiles of maternal and fetal placental macrophages at term are associated with gravidity
Distinct transcriptional profiles of maternal and fetal placental macrophages at term are associated with gravidity Open
Maternal intervillous monocytes (MIMs) and fetal Hofbauer cells (HBCs) are myeloid-derived immune cells at the maternal-fetal interface. Little is known regarding the molecular phenotypes and roles of these distinct monocyte/macrophage pop…
View article: Perfluorooctanoic acid induces transcriptomic alterations in second trimester human cytotrophoblasts
Perfluorooctanoic acid induces transcriptomic alterations in second trimester human cytotrophoblasts Open
Poly- and perfluroroalkylated substances (PFAS) are a major class of surfactants used in industry applications and consumer products. Despite efforts to reduce the usage of PFAS due to their environmental persistence, compounds such as per…
View article: Protocol: Testing the performance of INVITES-IN, a tool for assessing the internal validity of in vitro studies
Protocol: Testing the performance of INVITES-IN, a tool for assessing the internal validity of in vitro studies Open
A tool for evaluation of internal validity of in vitro studies called INVITES-IN is currently under development. The tool is designed specifically for cell culture studies. This protocol describes the testing of the performance of…
View article: Protocol for designing INVITES-IN, a tool for assessing the internal validity of <i>in vitro</i> studies
Protocol for designing INVITES-IN, a tool for assessing the internal validity of <i>in vitro</i> studies Open
This protocol describes the design and development of a tool for evaluation of the internal validity of in vitro studies, which is needed to include the data as evidence in systematic reviews and chemical risk assessments. The tool …
View article: Minimal mRNA uptake and inflammatory response to COVID-19 mRNA vaccine exposure in human placental explants
Minimal mRNA uptake and inflammatory response to COVID-19 mRNA vaccine exposure in human placental explants Open
Despite universal recommendations for COVID-19 mRNA vaccination in pregnancy, uptake has been lower than desired. There have been limited studies of the direct impact of COVID-19 mRNA vaccine exposure in human placental tissue. Using a pri…
View article: Proteomic analyses of primary human villous trophoblasts exposed to flame retardant BDE-47 using SWATH-MS
Proteomic analyses of primary human villous trophoblasts exposed to flame retardant BDE-47 using SWATH-MS Open
View article: Retrospective analysis of wildfire smoke exposure and birth weight outcomes in the San Francisco Bay Area of California
Retrospective analysis of wildfire smoke exposure and birth weight outcomes in the San Francisco Bay Area of California Open
Despite the occurrence of wildfires quadrupling over the past four decades, the health effects associated with wildfire smoke exposures during pregnancy remains unknown. Particulate matter less than 2.5 μ ms (PM 2.5 ) is among the major po…
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Issue Information Open
View article: Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies
Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies Open
Methods to generate evidence for regulatory toxicology are increasingly shifting from classical animal experiments to new approach methodologies (NAMs), with a corresponding need for methods to incorporate them in systematic reviews and ot…