Explanipedia

Compartmentalization of Transcripts During Antibody Mediated Rejection in Renal Transplants Open

Dajana Margeta, Hirotsugu Noguchi, Sepideh Khazaie, Leal Herlitz, Joshua J. Augustine , et al. · 2024

We used Digital Spatial Profiling to localize transcripts in glomeruli and tubulointerstitial compartments in a series of 4 biopsies from a patient diagnosed with acute antibody-mediated rejection (AMR). The 4 biopsies included: a baseline…

Prospective observational study to validate a next-generation sequencing blood RNA signature to predict early kidney transplant rejection Open

Oriol Bestard, Joshua J. Augustine, Alvin Wee, Emilio D. Poggio, Roslyn B. Mannon , et al. · 2023

The objective of this study was to validate the performance of Tutivia, a peripheral blood gene expression signature, in predicting early acute rejection (AR) post-kidney transplant. Recipients of living or deceased donor kidney transplant…

Performance of estimated glomerular filtration rate equations in Black living kidney donor candidates Open

Joshua J. Augustine, Aimen Liaqat, Susana Arrigain, Jesse D. Schold, Emilio D. Poggio · 2023

Introduction New estimated glomerular filtration rate (eGFR) equations using serum creatinine and/or cystatin C have been derived to eliminate adjustment by perceived Black ancestry. We sought to analyze the performance of newer eGFR equat…

The Number and Size of Individual Kidney Medullary Pyramids is Associated with Clinical Characteristics, Kidney Biopsy Findings, and CKD Outcomes among Kidney Donors Open

Adriana Gregory, Aleksandar Đenić, Amr A. Moustafa, Praveen G. Dasaraju, Bhavya Poudyal , et al. · 2023

Significance Statement Segmentation of multiple structures in cross-sectional imaging is time-consuming and impractical to perform manually, especially if the end goal is clinical implementation. In this study, we developed, validated, and…

Age-Based Versus Young-Adult Thresholds for Nephrosclerosis on Kidney Biopsy and Prognostic Implications for CKD Open

Muhammad Sohaib Asghar, Aleksandar Đenić, Aidan F. Mullan, Amr A. Moustafa, Laura Barisoni , et al. · 2023

Significance Statement Nephrosclerosis (glomerulosclerosis, interstitial fibrosis, and tubular atrophy) is the defining pathology of both kidney aging and CKD. Optimal thresholds for nephrosclerosis that identify persons with a progressive…

An Improved Method for Estimating Nephron Number and the Association of Resulting Nephron Number Estimates with Chronic Kidney Disease Outcomes Open

Aleksandar Đenić, Aidan F. Mullan, Mariam P. Alexander, Luke D. Wilson, Joshua J. Augustine , et al. · 2023

Significance Statement Nephron number currently can be estimated only from glomerular density on a kidney biopsy combined with cortical volume from kidney imaging. Because of measurement biases, refinement of this approach and validation a…

Performance of New Estimated GFR Equations in Kidney Transplant Recipients: A Step in the Right Direction Open

Aimen Liaqat, Joshua J. Augustine, Emilio D. Poggio · 2022

Automated Segmentation of Kidney Cortex and Medulla in CT Images: A Multisite Evaluation Study Open

Panagiotis Korfiatis, Aleksandar Đenić, Marie E. Edwards, Adriana Gregory, Darryl Wright , et al. · 2021

Background In kidney transplantation, a contrast CT scan is obtained in the donor candidate to detect subclinical pathology in the kidney. Recent work from the Aging Kidney Anatomy study has characterized kidney, cortex, and medulla volume…

Beyond the Biopsy: Monitoring Immune Status in Kidney Recipients Open

Roy D. Bloom, Joshua J. Augustine · 2021

Improved long-term kidney allograft survival is largely related to better outcomes at 12 months, in association with declining acute rejection rates and more efficacious immunosuppression. Finding the right balance between under- and overi…

Renal function outcomes and kidney biopsy features of living kidney donors with hypertension Open

Massini Merzkani, Aidan F. Mullan, Aleksandar Đenić, Matthew R. D’Costa, Ryan Iverson , et al. · 2021

Background The medium‐ to long‐term outcomes of living kidney donors with hypertension compared to normotensive donors are not well understood, especially with the recent changes in hypertension guidelines. Methods We studied a cohort of 9…

Failure to Advance Access to Kidney Transplantation over Two Decades in the United States Open

Jesse D. Schold, Sumit Mohan, Anne M. Huml, Laura D. Buccini, John R. Sedor , et al. · 2021

Significance Statement There have been numerous research studies and policies developed to improve access to kidney transplantation among patients with ESKD over past decades. In this retrospective cohort study, the authors evaluated the l…

COVID-19 and the kidney Open

Mohamed Hassanein, Yeshwanter Radhakrishnan, John R. Sedor, Tushar J. Vachharajani, Vidula Vachharajani , et al. · 2020

COVID-19 is primarily considered a respiratory illness, but the kidney may be one of the targets of SARS-CoV-2 infection, since the virus enters cells through the angiotensin-converting enzyme 2 receptor, which is found in abundance in the…

Effects of body mass index on kidney transplant outcomes are significantly modified by patient characteristics Open

Jesse D. Schold, Joshua J. Augustine, Anne M. Huml, Richard Fatica, Samuel Nurko , et al. · 2020

The National Kidney Registry Open

Bushra Syed, Joshua J. Augustine · 2020

In this issue of CJASN, Leeser et al. (1) describe patient and graft survival in patients who participated in the National Kidney Registry, a nonprofit, 501(c) organization founded in 2007 to facilitate living kidney donor exchange. Outcom…

Kidney Structural Features from Living Donors Predict Graft Failure in the Recipient Open

Naim Issa, Camden Lopez, Aleksandar Đenić, Sandra J. Taler, Joseph J. Larson , et al. · 2020

Significance Statement The quality of a kidney obtained from a living donor is often inferred from the donor’s age, risk factors, and kidney function. Little is known about the influence of a donated kidney’s structural features on the ris…

Modest rates and wide variation in timely access to repeat kidney transplantation in the United States Open

Jesse D. Schold, Joshua J. Augustine, Anne M. Huml, John O’Toole, John R. Sedor , et al. · 2019

Success of transplantation is not limited to initial receipt of a donor organ. Many kidney transplant recipients experience graft loss following initial transplantation and the benefits of expedited placement on the waiting list and retran…

Global Glomerulosclerosis in Kidney Biopsies With Differing Amounts of Cortex: A Clinical-Pathologic Correlation Study Open

Robert S. Niznik, Camden Lopez, Walter K. Kremers, Aleksandar Đenić, Sanjeev Sethi , et al. · 2019

Diagnostic Performance of Blood Pressure Measurement Modalities in Living Kidney Donor Candidates Open

Sherif Armanyous, Yasushi Ohashi, Michael Lioudis, Jesse D. Schold, George Thomas , et al. · 2019

Background and objectives Precise BP measurement to exclude hypertension is critical in evaluating potential living kidney donors. Ambulatory BP monitoring is considered the gold standard method for diagnosing hypertension, but it is cumbe…

Larger nephron size, low nephron number, and nephrosclerosis on biopsy as predictors of kidney function after donating a kidney Open

Naim Issa, Lisa E. Vaughan, Aleksandar Đenić, Walter K. Kremers, Harini A. Chakkera , et al. · 2019

Dampier Peninsula's Community Navigators: Empowering Kimberley Families through their Aboriginal-led Woombooriny Amboon Angarriiya Partnership Initiative (WAAPI) Open

Jessica Bunning, Janella Isaac, Rosana Smith, Joshua J. Augustine, Belinda Sampi · 2019

The Dampier Peninsula is home to a pristine coastal landscape and rugged country with diverse and abundant marine life, flora and fauna. Valuable Aboriginal cultural knowledge, traditions and science are still shared and practiced, while l…

Comparison of high glomerular filtration rate thresholds for identifying hyperfiltration Open

Harini A. Chakkera, Aleksandar Đenić, Walter K. Kremers, Mark D. Stegall, Joseph J. Larson , et al. · 2018

Background High glomerular filtration rate (GFR) is often used as a surrogate for single-nephron hyperfiltration. Our objective was to determine the definition for high GFR that best reflects clinical and structural characteristics of hype…

Racial disparity in kidney transplant survival relates to late rejection and is independent of steroid withdrawal Open

Angela Liu, Kenneth J. Woodside, Joshua J. Augustine, Nagaraju Sarabu · 2018

Black kidney transplant recipients have more acute rejection (AR) and inferior graft survival. We sought to determine whether early steroid withdrawal (ESW) had an impact on AR and death‐censored graft loss (DCGL) in blacks. From 2006 to 2…

Dramatic secular changes in prognosis for kidney transplant candidates in the United States Open

Jesse D. Schold, Susana Arrigain, Stuart M. Flechner, Joshua J. Augustine, John R. Sedor , et al. · 2018

Over recent decades, numerous clinical advances and policy changes have affected outcomes for candidates of kidney transplantation in the United States. We examined the national Scientific Registry for Transplant Recipients for adult (18+)…

Significantly Lower Rates of Kidney Transplantation among Candidates Listed with the Veterans Administration: A National and Local Comparison Open

Joshua J. Augustine, Susana Arrigain, Krishna Balabhadrapatruni, Niraj Desai, Jesse D. Schold · 2018

Background The process for evaluating kidney transplant candidates and applicable centers is distinct for patients with Veterans Administration (VA) coverage. We compared transplant rates between candidates on the kidney waiting list with …

Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume Open

Aleksandar Đenić, Jerry Mathew, Venkata V. Nagineni, R. Houston Thompson, Bradley C. Leibovich , et al. · 2018

Background Glomerular volume increases when demand exceeds nephron supply, which may lead to glomerulosclerosis. It is unclear if determinants of glomerular volume are consistent between populations that differ by severity of comorbidities…

LBA17 DONOR VISCERAL ADIPOSE TISSUE BETTER PREDICTOR OF LONG-TERM RENAL FUNCTION DECLINE THAN BODY MASS INDEX Open

Karen Stern, Sherif Armanyous, Erick M. Remer, Ryan Ward, Joshua J. Augustine , et al. · 2018

You have accessJournal of UrologyPlenary: Next Frontier1 Apr 2018LBA17 DONOR VISCERAL ADIPOSE TISSUE BETTER PREDICTOR OF LONG-TERM RENAL FUNCTION DECLINE THAN BODY MASS INDEX Karen Stern, Sherif Armanyous, Erick Remer, Ryan Ward, Joshua Au…

Hepatitis C treatment in kidney transplant recipients: the need for sustained vigilance after sustained viral response Open

Ziad Zaky, Joshua J. Augustine · 2018

Kidney transplant: New opportunities and challenges Open

Joshua J. Augustine · 2018

Progress in kidney transplant has improved survival while creating challenges. The pool of eligible patients is increasing, but organ supply remains inadequate. Waiting-list issues, adequate pretransplant assessment, judicious use of poten…

Morphometric age and survival following kidney transplantation Open

Michael N. Terjimanian, Patrick W. Underwood, David C. Cron, Joshua J. Augustine, Kelly A. Noon , et al. · 2017

Background As patients with chronic kidney disease become older, there is greater need to identify who will most benefit from kidney transplantation. Analytic morphomics has emerged as an objective risk assessment tool distinct from chrono…

Using analytic morphomics to describe body composition associated with post‐kidney transplantation diabetes mellitus Open

David C. Cron, Kelly A. Noon, Devan R. Cote, Michael N. Terjimanian, Joshua J. Augustine , et al. · 2017

Background Better risk assessment tools are needed to predict post‐transplantation diabetes mellitus ( PTDM ). Using analytic morphomic measurements from computed tomography ( CT ) scans, we aimed to identify specific measures of body comp…

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