Joshua Justice
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View article: Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures
Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures Open
Huntington’s disease (HD) is a debilitating neurodegenerative disorder affecting an individual’s cognitive and motor abilities. HD is caused by a mutation in the huntingtin gene producing a toxic polyglutamine-expanded protein (mHTT) and l…
View article: The Role of Defects on SiC Device Performance and Ways to Mitigate them
The Role of Defects on SiC Device Performance and Ways to Mitigate them Open
Several defects were analyzed through the manufacturing chain along with their impact on devices. High kill rate of micropipes were seen on both Diodes and MOSFETs as expected. The purity of micropipe detection was found to be affected by …
View article: Body Diode Reliability of 4H-SiC MOSFETs as a Function of Epitaxial Process Parameter
Body Diode Reliability of 4H-SiC MOSFETs as a Function of Epitaxial Process Parameter Open
In this paper, the authors continue the experimental evaluation of bipolar degradation for different 1.2 kV SiC MOSFETs. All the devices are stressed by pulsed repetitive forward current through the body diode with current densities varyin…
View article: Sirtuin 2 promotes human cytomegalovirus replication by regulating cell cycle progression
Sirtuin 2 promotes human cytomegalovirus replication by regulating cell cycle progression Open
The ability to modulate host cell cycle progression is a requirement of many human viruses in order to facilitate their replication and propagation. Nuclear-replicating DNA viruses frequently stall the host cell cycle in G1 to avoid compet…
View article: Pulsed Forward Bias Body Diode Stress of 1200 v SiC MOSFETs with Individual Mapping of Basal Plane Dislocations
Pulsed Forward Bias Body Diode Stress of 1200 v SiC MOSFETs with Individual Mapping of Basal Plane Dislocations Open
Bipolar degradation is a known problem in the development of SiC MOSFETs when the body diodes (p+ body/ n-drift layer) are forward biased. Mostly higher voltage classes like the 1.7 kV or 3.3 kV SiC MOSFETs have been studied in literature …
View article: Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections
Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections Open
Communication between infected cells and cells in the surrounding tissue is a determinant of viral spread. However, it remains unclear how cells in close or distant proximity to an infected cell respond to primary or secondary infections. …
View article: A Deeper Look into the Effects of Extended Defects in SiC Epitaxial Layers on Device Performance and Reliability
A Deeper Look into the Effects of Extended Defects in SiC Epitaxial Layers on Device Performance and Reliability Open
The detection and classification of SiC Epitaxial extended defects was refined to separate out defective areas that influence device characteristics. Die level defect localization along with defect area calculations were performed on milli…
View article: SiC Diode with Vertical Superjunction Realized Using Channeled Implant and Multi-Step Epitaxial Growth
SiC Diode with Vertical Superjunction Realized Using Channeled Implant and Multi-Step Epitaxial Growth Open
This work details two approaches with multi-epitaxial growth to create a vertical superjunction structure made of alternating pillars. One approach is a chain of very high energy implants, the other uses a preferred implantation direction …
View article: Pulsed Forward Bias Body Diode Stress of 1700 V SiC MOSFETs with Individual Mapping of Basal Plane Dislocations
Pulsed Forward Bias Body Diode Stress of 1700 V SiC MOSFETs with Individual Mapping of Basal Plane Dislocations Open
In this work, body diode stress has been carried out for 1700 V 25 mΩ planar SiC MOSFETs. The epitaxial wafers were mapped with Infra-Red photoluminescence (IR-PL) to determine and localize the exact number of basal plane dislocations pres…
View article: Nuclear antiviral innate responses at the intersection of DNA sensing and DNA repair
Nuclear antiviral innate responses at the intersection of DNA sensing and DNA repair Open
View article: BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation Open
Since there are no therapeutics that target BKPyV reactivation in organ transplant patients, it is currently treated by decreasing immunosuppression to allow the natural immune system to fight the viral infection. Antivirals would signific…
View article: Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity
Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity Open
The functional interaction landscape of HSV-1 infection uncovers a link between immune sensing and the DNA damage response.
View article: Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair
Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair Open
The integrity and regulation of the nuclear lamina is essential for nuclear organization and chromatin stability, with its dysregulation being linked to laminopathy diseases and cancer. Although numerous posttranslational modifications hav…
View article: A high-stringency blueprint of the human proteome
A high-stringency blueprint of the human proteome Open
View article: BK Polyomavirus Activates the DNA Damage Response To Prolong S Phase
BK Polyomavirus Activates the DNA Damage Response To Prolong S Phase Open
BK polyomavirus (BKPyV) is an emerging pathogen that reactivates in immunosuppressed organ transplant patients. We wanted to understand why BKPyV-induced activation of the DNA damage response (DDR) enhances viral titers and prevents host D…
View article: Phylogenetic utility, and variability in structure and content, of complete mitochondrial genomes among genetic lineages of the Hawaiian anchialine shrimp <i>Halocaridina rubra</i> Holthuis 1963 (Atyidae:Decapoda)
Phylogenetic utility, and variability in structure and content, of complete mitochondrial genomes among genetic lineages of the Hawaiian anchialine shrimp <i>Halocaridina rubra</i> Holthuis 1963 (Atyidae:Decapoda) Open
The Atyidae are caridean shrimp possessing hair-like setae on their claws and are important contributors to ecological services in tropical and temperate fresh and brackish water ecosystems. Complete mitochondrial genomes have only been re…
View article: Polyomavirus interaction with the DNA damage response
Polyomavirus interaction with the DNA damage response Open
View article: Viral DNA Replication-Dependent DNA Damage Response Activation during BK Polyomavirus Infection
Viral DNA Replication-Dependent DNA Damage Response Activation during BK Polyomavirus Infection Open
BK polyomavirus (BKPyV) reactivation is associated with severe human disease in kidney and bone marrow transplant patients. The interplay between viral and host factors that regulates the productive infection process remains poorly underst…