Joshua Kranrod
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View article: Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer
Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) cells exhibit high metabolic flexibility, enabling survival under glucose limitation by using alternative fuels such as fatty acids. Lipophagy, a selective form of autophagy targeting lipid droplets …
View article: Matrix metalloproteinase inhibition protects against junctophilin‐2 proteolysis during doxorubicin‐induced cardiotoxicity
Matrix metalloproteinase inhibition protects against junctophilin‐2 proteolysis during doxorubicin‐induced cardiotoxicity Open
Background and Purpose Treatment of cancer patients with anthracyclines is known to cause dose‐dependent cardiotoxicity through several mechanisms including enhanced oxidative stress, ultimately resulting in defective excitation–contractio…
View article: The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart
The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart Open
Cellular senescence is a condition characterized by stable, irreversible cell cycle arrest linked to the aging process. The accumulation of senescent cells in the cardiac muscle can contribute to various cardiovascular diseases (CVD). Telo…
View article: Linoleic acid‐derived diol 12,13‐ <scp>DiHOME</scp> enhances <scp>NLRP3</scp> inflammasome activation in macrophages
Linoleic acid‐derived diol 12,13‐ <span>DiHOME</span> enhances <span>NLRP3</span> inflammasome activation in macrophages Open
12,13‐dihydroxy‐9z‐octadecenoic acid (12,13‐DiHOME) is a linoleic acid diol derived from cytochrome P‐450 (CYP) epoxygenase and epoxide hydrolase (EH) metabolism. 12,13‐DiHOME is associated with inflammation and mitochondrial damage in the…
View article: Cardioprotective properties of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids
Cardioprotective properties of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids Open
OMT-28 is a metabolically robust small molecule developed to mimic the structure and function of omega-3 epoxyeicosanoids. However, it remained unknown to what extent OMT-28 also shares the cardioprotective and anti-inflammatory properties…
View article: Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells
Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells Open
View article: Cardioprotective Action of a Novel Synthetic 19,20-EDP Analog Is Sirt Dependent
Cardioprotective Action of a Novel Synthetic 19,20-EDP Analog Is Sirt Dependent Open
Mounting evidence suggests that cytochrome P450 epoxygenase–derived metabolites of docosahexaenoic acid, called epoxydocosapentaenoic acids (EDPs), limit mitochondrial damage after cardiac injury. In particular, the 19,20-EDP regioisomer h…
View article: Effects of SP-2509 and OG-L002 on lipophagy using target or off-target molecules in glycolysis-suppressed pancreatic ductal adenocarcinoma cells
Effects of SP-2509 and OG-L002 on lipophagy using target or off-target molecules in glycolysis-suppressed pancreatic ductal adenocarcinoma cells Open
Although increased aerobic glycolysis is common in cancers, pancreatic ductal adenocarcinoma (PDAC) cells can survive glycolysis suppression. We aimed to identify potential therapeutic targets in glycolysis-suppressed PDAC cells. By screen…
View article: Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway
Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway Open
Background: Myocardial hypertrophy and dilation are key features of cardiomyopathies and involve several cellular and molecular events. ADAMs (a disintegrin and metalloproteinases) are membrane-bound proteinases with diverse functions whos…