Joshua P. Fessel
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View article: Reflections from Research Roundtables at the Conference on Health, Inference, and Learning (CHIL) 2025
Reflections from Research Roundtables at the Conference on Health, Inference, and Learning (CHIL) 2025 Open
The 6th Annual Conference on Health, Inference, and Learning (CHIL 2025), hosted by the Association for Health Learning and Inference (AHLI), was held in person on June 25-27, 2025, at the University of California, Berkeley, in Berkeley, C…
View article: With Sadness and Resolve: Why I Resigned as Chief Medical Officer of a National Institutes of Health Institute and What Comes Next
With Sadness and Resolve: Why I Resigned as Chief Medical Officer of a National Institutes of Health Institute and What Comes Next Open
View article: Digital Health Technology Research Funded by the National Institutes of Health
Digital Health Technology Research Funded by the National Institutes of Health Open
Importance Digital health in biomedical research and its expanding list of potential clinical applications are rapidly evolving. A combination of new digital health technologies (DHTs), novel uses of existing DHTs through artificial intell…
View article: Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future
Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future Open
The Accelerating COVID-19 Therapeutic Interventions and Vaccines Therapeutic-Clinical Working Group members gathered critical recommendations in follow-up to lessons learned manuscripts released earlier in the COVID-19 pandemic. Lessons ar…
View article: Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future
Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future Open
The Accelerating COVID-19 Therapeutic Interventions and Vaccines Therapeutic-Clinical Working Group members gathered critical recommendations in follow-up to lessons learned manuscripts released earlier in the COVID-19 pandemic. Lessons ar…
View article: Advancing regulatory science through real-world data and real-world evidence
Advancing regulatory science through real-world data and real-world evidence Open
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View article: Defining and Promoting Pediatric Pulmonary Health: A NHLBI Workshop Executive Summary
Defining and Promoting Pediatric Pulmonary Health: A NHLBI Workshop Executive Summary Open
View article: Paxlovid (nirmatrelvir/ritonavir) effectiveness against hospitalization and death in N3C: A target trial emulation study
Paxlovid (nirmatrelvir/ritonavir) effectiveness against hospitalization and death in N3C: A target trial emulation study Open
Importance COVID-19 has placed a monumental burden on the health care system globally. Although no longer a public health emergency, there is still a pressing need for effective treatments to prevent hospitalization and death. Paxlovid (ni…
View article: Beyond the symptom: the biology of fatigue
Beyond the symptom: the biology of fatigue Open
A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience…
View article: A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male
A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male Open
We present a case study of a 20-year-old male with an unknown neurodegenerative disease who was referred to the Undiagnosed Diseases Network Vanderbilt Medical Center site. A previous metabolic panel showed that the patient had a critical …
View article: Real-world data for 21<sup>st</sup>-century medicine: The clinical and translational science awards program perspective
Real-world data for 21<sup>st</sup>-century medicine: The clinical and translational science awards program perspective Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the 'Save PDF' action button.
View article: Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation
Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation Open
View article: Impact of Sex and Gender on Autoimmune Lung Disease: Opportunities for Future Research: NHLBI Working Group Report
Impact of Sex and Gender on Autoimmune Lung Disease: Opportunities for Future Research: NHLBI Working Group Report Open
"Impact of Sex and Gender on Autoimmune Lung Disease: Opportunities for Future Research: NHLBI Working Group Report." American Journal of Respiratory and Critical Care Medicine, 206(7), pp. 817–823
View article: Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines—Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials
Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines—Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials Open
Given the urgent need for coronavirus disease 2019 therapeutics, early in the pandemic the Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership rapidly designed a unique therapeuti…
View article: NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification
NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification Open
View article: Diagnosing and treating lung disease at the cellular level
Diagnosing and treating lung disease at the cellular level Open
View article: Enhanced Expression of Catalase in Mitochondria Modulates NF-κB–Dependent Lung Inflammation through Alteration of Metabolic Activity in Macrophages
Enhanced Expression of Catalase in Mitochondria Modulates NF-κB–Dependent Lung Inflammation through Alteration of Metabolic Activity in Macrophages Open
NF-κB is a reduction-oxidation–sensitive transcription factor that plays a key role in regulating the immune response. In these studies, we intended to investigate the role of mitochondrial-derived reactive oxygen species in regulating NF-…
View article: PET Imaging of Glutamine Uptake in Lymphangioleiomyomatosis
PET Imaging of Glutamine Uptake in Lymphangioleiomyomatosis Open
View article: Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension
Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is increasingly recognized as a systemic disease driven by alteration in the normal functioning of multiple metabolic pathways affecting all of the major carbon substrates, including amino acids. We fo…
View article: <i>BMPR2</i> dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes
<i>BMPR2</i> dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes Open
Insulin resistance and right ventricular (RV) dysfunction are associated with lipotoxicity in heritable forms of pulmonary arterial hypertension (PAH), commonly due to mutations in bone morphogenetic protein receptor type 2 (BMPR2). How BM…
View article: A Perspective: Division of Lung Diseases at Fifty
A Perspective: Division of Lung Diseases at Fifty Open
21-year-old National Heart Institute to become the National Heart and Lung Institute (NHLI) to consolidate pulmonary research from across NIH under one office.Over the last 50 years, this office, which became the Division of Lung Diseases …
View article: Abstract 2894: Overcoming intrinsic resistance to<i>BRAF</i>-inhibitors by modulating redox balance in<i>BRAF</i>-mutated melanoma cells
Abstract 2894: Overcoming intrinsic resistance to<i>BRAF</i>-inhibitors by modulating redox balance in<i>BRAF</i>-mutated melanoma cells Open
Post-resistant tumor analyses or static measurements provide most of our current knowledge of tumor recurrence. Unfortunately, these studies neither elucidate critical events that precede resistance nor explain the dynamics of drug respons…
View article: Mitochondrial DNA Haplogroups and Delirium During Sepsis
Mitochondrial DNA Haplogroups and Delirium During Sepsis Open
Objectives: Studies suggest that mitochondrial dysfunction underlies some forms of sepsis-induced organ failure. We sought to test the hypothesis that variations in mitochondrial DNA haplogroup affect susceptibility to sepsis-associated de…
View article: Low‐grade albuminuria in pulmonary arterial hypertension
Low‐grade albuminuria in pulmonary arterial hypertension Open
Low‐grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the …
View article: Human PAH is characterized by a pattern of lipid-related insulin resistance
Human PAH is characterized by a pattern of lipid-related insulin resistance Open
NIH DK096994, HL060906, UL1 RR024975-01, UL1 TR000445-06, DK020593, P01 HL108800-01A1, and UL1 TR002243; American Heart Association 13FTF16070002.
View article: Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study
Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study Open
Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 famil…
View article: Author response: Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study
Author response: Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Bcl-2 family proteins reorgan…
View article: A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is a deadly disease with no cure. Alternate conversion of angiotensin II (AngII) to angiotensin-(1–7) (Ang-(1–7)) by angiotensin-converting enzyme 2 (ACE2) resulting in Mas receptor (Mas1) activation i…
View article: Lower Concentrations of Circulating Medium and Long-Chain Acylcarnitines Characterize Insulin Resistance in Persons with HIV
Lower Concentrations of Circulating Medium and Long-Chain Acylcarnitines Characterize Insulin Resistance in Persons with HIV Open
In human immunodeficiency virus (HIV)-negative individuals, a plasma metabolite profile, characterized by higher levels of branched-chain amino acids (BCAA), aromatic amino acids, and C3/C5 acylcarnitines, is associated with insulin resist…
View article: Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA
Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA Open
Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M1dG, a major endogeno…