Joshua G. Pierce
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View article: Bioinspired synthesis of a lactam analogue of abyssomicin C
Bioinspired synthesis of a lactam analogue of abyssomicin C Open
View article: Toxicology study of a tissue anchoring paclitaxel prodrug
Toxicology study of a tissue anchoring paclitaxel prodrug Open
View article: Toxicology study of a tissue anchoring paclitaxel prodrug
Toxicology study of a tissue anchoring paclitaxel prodrug Open
View article: Synthesis of Spiropyrrolines <i>via</i> One-Pot Tf<sub>2</sub>O-Mediated Amide Activation/Formal [3 + 2]-Cycloaddition of α-Formylamino Ketones
Synthesis of Spiropyrrolines <i>via</i> One-Pot Tf<sub>2</sub>O-Mediated Amide Activation/Formal [3 + 2]-Cycloaddition of α-Formylamino Ketones Open
An efficient method for the synthesis of spiropyrrolines from readily accessible α-formylamino ketones is reported. The method involves amide activation using Tf2O, followed by a formal [3 + 2]-cycloaddition of the resulting eno…
View article: Fighting fibrin with fibrin: Vancomycin delivery into coagulase‐mediated <i>Staphylococcus aureus</i> biofilms via fibrin‐based nanoparticle binding
Fighting fibrin with fibrin: Vancomycin delivery into coagulase‐mediated <i>Staphylococcus aureus</i> biofilms via fibrin‐based nanoparticle binding Open
Staphylococcus aureus skin and soft tissue infection is a common ailment placing a large burden upon global healthcare infrastructure. These bacteria are growing increasingly recalcitrant to frontline antimicrobial therapeutics like vancom…
View article: An enantioselective formal synthesis of thienamycin
An enantioselective formal synthesis of thienamycin Open
View article: Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues
Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues Open
New antimicrobial scaffolds are scarce, and there is a great need for the development of novel therapeutics. In this study, we report a convergent 9-step synthesis of leopolic acid A and a series of targeted analogues. The designed compoun…
View article: Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity
Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity Open
View article: Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate <i>S. aureus</i> biofilms
Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate <i>S. aureus</i> biofilms Open
Due to the looming risk of a new pre-antibiotic era, we report the synthesis and evaluation of a novel library of pyrrolidine-2,3-diones. As a new class of antimicrobials, these compounds have shown promising effectiveness against S. aureu…
View article: Photoredox Catalyzed C(sp<sup>3</sup>)–C(sp<sup>3</sup>) Coupling of α-Bromoesters and Triethylamine
Photoredox Catalyzed C(sp<sup>3</sup>)–C(sp<sup>3</sup>) Coupling of α-Bromoesters and Triethylamine Open
We report a photoredox methodology for C(sp3)-C(sp3) coupling between α-bromoesters and triethylamine capable of accessing building blocks with handles for further functionalization. Mechanistic studies indicate the p…
View article: Using Stem Mini-Organs to Find New Cures
Using Stem Mini-Organs to Find New Cures Open
Developing a new drug can cost as much as a billion dollars, mostly due to the very large number of candidate drugs that fail before they get to the patient.Thus, finding ways to identify those "bad" drugs early can have a huge impact in r…
View article: CCDC 2176718: Experimental Crystal Structure Determination
CCDC 2176718: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2176727: Experimental Crystal Structure Determination
CCDC 2176727: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2177087: Experimental Crystal Structure Determination
CCDC 2177087: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Total Synthesis of Bipolamine I
Total Synthesis of Bipolamine I Open
Indolizidine alkaloids have been the target of chemical and biological studies for decades, most recently highlighted by the isolation of the curvulamine and bipolamine polypyrrole-containing subclass. Herein we report a stereoselective 15…
View article: Chemistry Drives Solutions to Our Planet’s Largest Problems: COVID-19 and Beyond
Chemistry Drives Solutions to Our Planet’s Largest Problems: COVID-19 and Beyond Open
Note that this video was recorded in 2020, so some of the content about COVID-19 reflects the state of knowledge at that time, but is no longer accurate according to today's knowledge.Imagine a world where a small cut would often lead to d…
View article: Tissue-reactive drugs enable materials-free local depots
Tissue-reactive drugs enable materials-free local depots Open
View article: CCDC 2120591: Experimental Crystal Structure Determination
CCDC 2120591: Experimental Crystal Structure Determination Open
View article: CCDC 2120593: Experimental Crystal Structure Determination
CCDC 2120593: Experimental Crystal Structure Determination Open
View article: CCDC 2120592: Experimental Crystal Structure Determination
CCDC 2120592: Experimental Crystal Structure Determination Open
View article: CCDC 2120594: Experimental Crystal Structure Determination
CCDC 2120594: Experimental Crystal Structure Determination Open
View article: Stereoselective Synthesis of the Spirocyclic γ-Lactam Core of the Ansalactams
Stereoselective Synthesis of the Spirocyclic γ-Lactam Core of the Ansalactams Open
Ansalactam A is an ansa macrolide natural product that contains a densely functionalized spiro-γ-lactam core containing three contiguous stereocenters. This unusual motif distinguishes it from other members of this family and represents a …
View article: Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture
Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture Open
View article: Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach
Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach Open
View article: Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence
Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence Open
Antimicrobial resistance to existing antibiotics represents one of the greatest threats to human health and is growing at an alarming rate. To further complicate treatment of bacterial infections, many chronic infections are the result of …
View article: Genetic Determinants of <i>Salmonella</i> Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog
Genetic Determinants of <i>Salmonella</i> Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog Open
Biofilms are resistant to killing by disinfectants and antimicrobials. S. enterica biofilms facilitate long-term host colonization and persistence in food processing environments. Synthetic analogs of 4-oxazolidinone natural products show …
View article: CCDC 1991570: Experimental Crystal Structure Determination
CCDC 1991570: Experimental Crystal Structure Determination Open
View article: Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds
Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds Open
The Amaryllidaceae alkaloids have been a target of synthesis for decades due to their complex architectures and biological activity. A central feature of these natural product cores is a quaternary substituted hydroindole heterocycle. Buil…
View article: Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy
Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy Open
Herein, we describe a stereodivergent route to (±)-batzelladine D (2), (+)-batzelladine D (2), (-)-batzelladine D (2), and a series of stereochemical analogues and explore their antimicrobial activity for the first tim…
View article: Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of <i>Staphylococcus aureus</i> Biofilms (ChemBioChem 7/2020)
Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of <i>Staphylococcus aureus</i> Biofilms (ChemBioChem 7/2020) Open
By using an expanded set of 5-benzylidene-4-oxazolidinones it was possible to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilms and—in combination with common antibiotics—to significantly reduce the bacte…