Joshua R. Sanes
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View article: Lynn Landmesser (1943–2024): A pioneer in developmental neurobiology
Lynn Landmesser (1943–2024): A pioneer in developmental neurobiology Open
Lynn Landmesser, whose studies transformed our view of how neurons find the proper partners on which to form synapses, died at the age of 80 in November 2024. Using elegant electrophysiological methods, she showed that specificity is appar…
View article: Altered proportions of retinal cell types and distinct visual codes in rodents occupying divergent ecological niches
Altered proportions of retinal cell types and distinct visual codes in rodents occupying divergent ecological niches Open
Vertebrate retinas share a basic blueprint comprising 5 neuronal classes arranged according to a common wiring diagram. Yet, vision is aligned with species differences in behavior and ecology, raising the question of how evolution acts on …
View article: Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells Open
View article: Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells Open
View article: Reconfiguration of the visual code and retinal cell type complement in closely related diurnal and nocturnal mice
Reconfiguration of the visual code and retinal cell type complement in closely related diurnal and nocturnal mice Open
How does evolution act on neuronal populations to match computational characteristics to functional demands? We address this problem by comparing visual code and retinal cell composition in closely related murid species with different beha…
View article: Comprehensive single-cell atlas of the mouse retina
Comprehensive single-cell atlas of the mouse retina Open
Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellular heterogeneity by characterizing cell types across tissues and species. While several mouse retinal scRNA-seq datasets exist, each dataset is either limited i…
View article: Ancient origin of the rod bipolar cell pathway in the vertebrate retina
Ancient origin of the rod bipolar cell pathway in the vertebrate retina Open
Vertebrates rely on rod photoreceptors for vision in low-light conditions. The specialized downstream circuit for rod signalling, called the primary rod pathway, is well characterized in mammals, but circuitry for rod signalling in non-mam…
View article: Evolutionary and developmental specialization of foveal cell types in the marmoset
Evolutionary and developmental specialization of foveal cell types in the marmoset Open
In primates, high-acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal matura…
View article: Comprehensive single-cell atlas of the mouse retina
Comprehensive single-cell atlas of the mouse retina Open
Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellular heterogeneity at the single-cell resolution by classifying and characterizing cell types in multiple tissues and species. While several mouse retinal scRNA-s…
View article: Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma Open
View article: Comprehensive Single-Cell Atlas of the Mouse Retina
Comprehensive Single-Cell Atlas of the Mouse Retina Open
View article: Evolution of neuronal cell classes and types in the vertebrate retina
Evolution of neuronal cell classes and types in the vertebrate retina Open
View article: Evolutionary and Developmental Specialization of Foveal Cell Types in the Marmoset
Evolutionary and Developmental Specialization of Foveal Cell Types in the Marmoset Open
In primates, high-acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal matura…
View article: Suppressing DNMT3a Alleviates the Intrinsic Epigenetic Barrier for Optic Nerve Regeneration and Restores Vision in Adult Mice
Suppressing DNMT3a Alleviates the Intrinsic Epigenetic Barrier for Optic Nerve Regeneration and Restores Vision in Adult Mice Open
The limited regenerative potential of the optic nerve in adult mammals presents a major challenge for restoring vision after optic nerve trauma or disease. The mechanisms of this regenerative failure are not fully understood 1,2 . Here, th…
View article: Integrated multi-omics single cell atlas of the human retina
Integrated multi-omics single cell atlas of the human retina Open
View article: Integrated multi-omics single cell atlas of the human retina
Integrated multi-omics single cell atlas of the human retina Open
Single-cell sequencing has revolutionized the scale and resolution of molecular profiling of tissues and organs. Here, we present an integrated multimodal reference atlas of the most accessible portion of the mammalian central nervous syst…
View article: Ancient origin of the rod bipolar cell pathway in the vertebrate retina
Ancient origin of the rod bipolar cell pathway in the vertebrate retina Open
Vertebrates rely on rod photoreceptors for vision in low-light conditions. Mammals have a specialized downstream circuit for rod signaling called the primary rod pathway, which comprises specific cell types and wiring patterns that are tho…
View article: Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting
Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting Open
Post-training increases in hippocampal neurogenesis are associated with forgetting of hippocampus-dependent memories in adult mice. This form of forgetting might be due to increased numbers of new neurons, remodeling of hippocampal circuit…
View article: Ancient origin of the rod bipolar cell pathway in the vertebrate retina
Ancient origin of the rod bipolar cell pathway in the vertebrate retina Open
Vertebrates rely on rod photoreceptors for vision in low-light conditions 1 . Mammals have a specialized downstream circuit for rod signaling called the primary rod pathway, which comprises specific cell types and wiring patterns that are …
View article: Transcriptomic analysis of the ocular posterior segment completes a cell atlas of the human eye
Transcriptomic analysis of the ocular posterior segment completes a cell atlas of the human eye Open
Although the visual system extends through the brain, most vision loss originates from defects in the eye. Its central element is the neural retina, which senses light, processes visual signals, and transmits them to the rest of the brain …
View article: Transcriptomic Analysis of the Ocular Posterior Segment Completes a Cell Atlas of the Human Eye
Transcriptomic Analysis of the Ocular Posterior Segment Completes a Cell Atlas of the Human Eye Open
Although the visual system extends through the brain, most vision loss originates from defects in the eye. Its central element is the neural retina, which senses light, processes visual signals, and transmits them to the rest of the brain …
View article: Evolution of neuronal cell classes and types in the vertebrate retina
Evolution of neuronal cell classes and types in the vertebrate retina Open
The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs (Baden et al., 2020). One might expect that retinal cell types evolved to accommodate these varied needs, but this has not be…
View article: Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells Open
View article: Encoding of environmental illumination by primate melanopsin neurons
Encoding of environmental illumination by primate melanopsin neurons Open
Light regulates physiology, mood, and behavior through signals sent to the brain by intrinsically photosensitive retinal ganglion cells (ipRGCs). How primate ipRGCs sense light is unclear, as they are rare and challenging to target for ele…
View article: Vision-Dependent and -Independent Molecular Maturation of Mouse Retinal Ganglion Cells
Vision-Dependent and -Independent Molecular Maturation of Mouse Retinal Ganglion Cells Open
View article: Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types
Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types Open
The anterior segment of the eye consists of the cornea, iris, ciliary body, crystalline lens, and aqueous humor outflow pathways. Together, these tissues are essential for the proper functioning of the eye. Disorders of vision have been as…
View article: Temporal single cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury
Temporal single cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury Open
Non-neuronal cells play key roles in the complex cellular interplay that follows central nervous system (CNS) insult. To understand this interplay at a tissue level, we generated a single-cell atlas of immune, glial and retinal pigment epi…
View article: Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression
Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression Open
View article: Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells Open
View article: Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells
Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells Open