Joshua S. Siegel
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View article: Trends in Hallucinogen-Related Emergency Department and Hospital Admissions, 2016 to 2023
Trends in Hallucinogen-Related Emergency Department and Hospital Admissions, 2016 to 2023 Open
This cohort study evaluates trends in emergency department (ED) visits and hospitalizations related to hallucinogen use in the United States.
View article: Motion impact score for detecting spurious brain-behavior associations
Motion impact score for detecting spurious brain-behavior associations Open
In-scanner head motion introduces systematic bias to resting-state fMRI functional connectivity (FC) not completely removed by denoising algorithms. Researchers studying traits associated with motion (e.g. psychiatric disorders) need to kn…
View article: Psychedelic Therapies
Psychedelic Therapies Open
View article: Correction: Psilocybin’s acute and persistent brain effects: a precision imaging drug trials
Correction: Psilocybin’s acute and persistent brain effects: a precision imaging drug trials Open
View article: Psilocybin’s acute and persistent brain effects: a precision imaging drug trial
Psilocybin’s acute and persistent brain effects: a precision imaging drug trial Open
Psilocybin (PSIL) is a psychedelic drug and a promising experimental therapeutic for many psychiatric conditions. Precision functional mapping (PFM) combines densely repeated resting state fMRI sampling and individual-specific network mapp…
View article: Stimulant medications affect arousal and reward, not attention
Stimulant medications affect arousal and reward, not attention Open
Prescription stimulants such as methylphenidate are being used by an increasing portion of the population, primarily children. These potent norepinephrine and dopamine reuptake inhibitors promote wakefulness, suppress appetite, enhance phy…
View article: The human brainstem’s red nucleus was upgraded to support goal-directed action
The human brainstem’s red nucleus was upgraded to support goal-directed action Open
The red nucleus, a large brainstem structure, coordinates limb movement for locomotion in quadrupedal animals. In humans, its pattern of anatomical connectivity differs from that of quadrupeds, suggesting a different purpose. Here, we appl…
View article: Resource-Efficient Decision Making in Constrained Machine Learning Using the Pareto Data Framework
Resource-Efficient Decision Making in Constrained Machine Learning Using the Pareto Data Framework Open
View article: Psilocybin desynchronizes the human brain
Psilocybin desynchronizes the human brain Open
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials 1–4 . In animal models, psilocybin induces …
View article: Estimating heterogeneity of treatment effect in psychiatric clinical trials
Estimating heterogeneity of treatment effect in psychiatric clinical trials Open
Currently, placebo-controlled clinical trials report mean change and effect sizes, which masks information about heterogeneity of treatment effects (HTE). Here, we present a method to estimate HTE and evaluate the null hypothesis (H 0 ) th…
View article: Better Biomarkers, Faster Drugs, Stronger Models: Progress Towards Precision Psychiatry.
Better Biomarkers, Faster Drugs, Stronger Models: Progress Towards Precision Psychiatry. Open
The 21st century has brought novel therapies and new therapeutic targets for major depressive disorder (MDD). Until recently all antidepressant medications targeted monoamines-serotonin, norepinephrine, and dopamine- and their r…
View article: Psychedelic 5-HT2A receptor agonism: neuronal signatures and altered neurovascular coupling.
Psychedelic 5-HT2A receptor agonism: neuronal signatures and altered neurovascular coupling. Open
Psychedelics are promising therapeutics for mood disorders due to their rapid, sustained results. These effects rely on serotonin (5-hydroxytryptamine) receptor agonism, especially at the 2A receptor (5-HT2AR). Human neuroimagin…
View article: Psychedelic 5-HT2A receptor agonism: neuronal signatures and altered neurovascular coupling.
Psychedelic 5-HT2A receptor agonism: neuronal signatures and altered neurovascular coupling. Open
Psychedelics hold therapeutic promise for mood disorders due to rapid, sustained results. Human neuroimaging studies have reported dramatic serotonin-2A receptor-(5-HT2AR)-dependent changes in functional brain reorganization that presumabl…
View article: Psilocybin desynchronizes brain networks
Psilocybin desynchronizes brain networks Open
1 Summary The relationship between the acute effects of psychedelics and their persisting neurobiological and psychological effects is poorly understood. Here, we tracked brain changes with longitudinal precision functional mapping in heal…
View article: Motion Impact Score for Detecting Spurious Brain-Behavior Associations
Motion Impact Score for Detecting Spurious Brain-Behavior Associations Open
Between-participant differences in head motion introduce systematic bias to resting state fMRI brain-wide association studies (BWAS) that is not completely removed by denoising algorithms. Researchers who study traits, or phenotypes associ…
View article: Psychedelic Drug Legislative Reform and Legalization in the US
Psychedelic Drug Legislative Reform and Legalization in the US Open
Importance Psychedelic drugs are becoming accessible in the US through a patchwork of state legislative reforms. This shift necessitates consensus on treatment models, education and guidance for health care professionals, and planning for …
View article: Plasticity markers in the human brain associated with rapid antidepressants
Plasticity markers in the human brain associated with rapid antidepressants Open
View article: Mapping correlated neurological deficits after stroke to distributed brain networks
Mapping correlated neurological deficits after stroke to distributed brain networks Open
View article: Temporal exponential random graph models of longitudinal brain networks after stroke
Temporal exponential random graph models of longitudinal brain networks after stroke Open
Plasticity after stroke is a complex phenomenon. Functional reorganization occurs not only in the perilesional tissue but throughout the brain. However, the local connection mechanisms generating such global network changes remain largely …
View article: File_S1 from Temporal exponential random graph models of longitudinal brain networks after stroke
File_S1 from Temporal exponential random graph models of longitudinal brain networks after stroke Open
Clinical and demographic information of stroke patients and healthy controls
View article: File S5: from Temporal exponential random graph models of longitudinal brain networks after stroke
File S5: from Temporal exponential random graph models of longitudinal brain networks after stroke Open
Analysis of variance (ANOVA) for the behavioral scores of stroke patients.
View article: File S4: from Temporal exponential random graph models of longitudinal brain networks after stroke
File S4: from Temporal exponential random graph models of longitudinal brain networks after stroke Open
Estimated tERGM coefficients for stroke patients and healthy controls
View article: File S3 from Temporal exponential random graph models of longitudinal brain networks after stroke
File S3 from Temporal exponential random graph models of longitudinal brain networks after stroke Open
Nuisance variables associated with fMRI recordings for stroke patients and healthy controls
View article: File S2: from Temporal exponential random graph models of longitudinal brain networks after stroke
File S2: from Temporal exponential random graph models of longitudinal brain networks after stroke Open
Multidomain behavioral recovery of stroke patients and helathy controls
View article: Effective connectivity extracts clinically relevant prognostic information from resting state activity in stroke
Effective connectivity extracts clinically relevant prognostic information from resting state activity in stroke Open
Recent resting-state functional MRI studies in stroke patients have identified two robust biomarkers of acute brain dysfunction: a reduction of inter-hemispheric functional connectivity between homotopic regions of the same network, and an…
View article: Individualized Functional Subnetworks Connect Human Striatum and Frontal Cortex
Individualized Functional Subnetworks Connect Human Striatum and Frontal Cortex Open
The striatum and cerebral cortex are interconnected via multiple recurrent loops that play a major role in many neuropsychiatric conditions. Primate corticostriatal connections can be precisely mapped using invasive tract-tracing. However,…
View article: Human Fronto-Striatal Connectivity is Organized into Discrete Functional Subnetworks
Human Fronto-Striatal Connectivity is Organized into Discrete Functional Subnetworks Open
The striatum is interconnected with the cerebral cortex via multiple recurrent loops that play a major role in many neuropsychiatric conditions. Primate cortico-striatal connections can be precisely mapped using invasive tract-tracing. How…
View article: Brain network reorganisation in an adolescent after bilateral perinatal strokes
Brain network reorganisation in an adolescent after bilateral perinatal strokes Open
View article: Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression
Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression Open
Ketamine produces a rapid antidepressant response in over 50% of adults with treatment-resistant depression. A long infusion of ketamine may provide durable remission of depressive symptoms, but the safety, efficacy, and neurobiological co…
View article: Effective connectivity extracts clinically relevant prognostic information from resting state activity in stroke
Effective connectivity extracts clinically relevant prognostic information from resting state activity in stroke Open
Recent resting-state fMRI studies in stroke patients have identified two robust biomarkers of acute brain dysfunction: a reduction of inter-hemispheric functional connectivity (FC) between homotopic regions of the same network, and an abno…