Josiah Gerdts
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View article: Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism
Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism Open
View article: Molecular Studies of SARM1, an Axonal Self-Destruction Switch
Molecular Studies of SARM1, an Axonal Self-Destruction Switch Open
Axons are neuronal extensions that make up the wiring of the nervous system. Recent studies have revealed that axons possess a unique and largely uncharacterized self-destruction program that may be a therapeutic target for diseases in whi…
View article: SARM1 activation triggers axon degeneration locally via NAD <sup>+</sup> destruction
SARM1 activation triggers axon degeneration locally via NAD <sup>+</sup> destruction Open
SARM1-driven axon degeneration Axons, the long protrusions of nerve cells, are programmed to self-destruct under certain conditions that occur during development, stress, or disease states. Gerdts et al. outline a biochemical mechanism tha…