Josiane F. Silva
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View article: Leishmania chagasi Dihydrofolate Reductase-Thymidylate Synthase Potential Inhibitors Identified by Virtual Screening
Leishmania chagasi Dihydrofolate Reductase-Thymidylate Synthase Potential Inhibitors Identified by Virtual Screening Open
Visceral leishmaniasis is a disease with high lethality indicators and considerable incidence in Latin America, Africa, and Asia. Given the need to develop new drugs to treat leishmaniasis, this study aimed to identify potential selective …
View article: Sex‐specific mechanisms of cerebral microvascular BK<sub>Ca</sub> dysfunction in a mouse model of Alzheimer's disease
Sex‐specific mechanisms of cerebral microvascular BK<sub>Ca</sub> dysfunction in a mouse model of Alzheimer's disease Open
INTRODUCTION Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing hemodynamic regulation. Large conductance Ca 2+ ‐activated K + channels (BK Ca ) regulate cerebrovascular reactivity and are impaired in AD. BK Ca activ…
View article: Nitro‐oxidation of BK<sub>Ca</sub> mediates neuro‐ and micro‐vascular dysfunction in female <i>5x‐FAD</i> mice
Nitro‐oxidation of BK<sub>Ca</sub> mediates neuro‐ and micro‐vascular dysfunction in female <i>5x‐FAD</i> mice Open
Background Cerebral microvascular dysfunction and nitro‐oxidative stress are present in patients with Alzheimer’s disease (AD) and may contribute to disease progression and severity. A pro‐nitro‐oxidative environment can lead to post‐trans…
View article: Acute Chikungunya Infection Induces Vascular Dysfunction by Directly Disrupting Redox Signaling in Endothelial Cells
Acute Chikungunya Infection Induces Vascular Dysfunction by Directly Disrupting Redox Signaling in Endothelial Cells Open
Chikungunya virus (CHIKV) infection is characterized by febrile illness, severe joint pain, myalgia, and cardiovascular complications. Given that CHIKV stimulates reactive oxygen species (ROS) and pro- and anti-inflammatory cytokines, even…
View article: Endothelial Kir2 channel dysfunction in aged cerebral parenchymal arterioles
Endothelial Kir2 channel dysfunction in aged cerebral parenchymal arterioles Open
Advanced age in mice (>2 yr, similar to a 70- to 80-yr-old human) impairs P2Y and Kir2 channel-induced dilation. Reductions in endothelial Kir2 activity were associated with lower vasodilatory response to purinergic receptor activation and…
View article: Sex-specific mechanisms of cerebral microvascular BK<sub>Ca</sub>dysfunction in a mouse model of Alzheimer’s disease
Sex-specific mechanisms of cerebral microvascular BK<sub>Ca</sub>dysfunction in a mouse model of Alzheimer’s disease Open
Background Cerebral microvascular dysfunction and nitro-oxidative stress are present in patients with Alzheimer’s disease (AD) and may contribute to disease progression and severity. Large conductance Ca 2+ -activated K + channels (BK Ca )…
View article: Lectin Purification through Affinity Chromatography Exploiting Macroporous Monolithic Adsorbents
Lectin Purification through Affinity Chromatography Exploiting Macroporous Monolithic Adsorbents Open
Growing medical, engineering, biochemical, and biological interest has led to a steady pace of research and development into polymeric monolithic structures with densely interconnected pores for purifying bio compounds. Cryogels, which are…
View article: Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice
Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice Open
Cerebral parenchymal arterioles from menopause mice showed increased myogenic tone. We identified an impairment in smooth muscle cell BK Ca channel activity, without a reduction in endothelium-dependent dilation or nitric oxide production.…
View article: Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis
Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis Open
Objective: The mechanisms involved in NOX5 activation in atherosclerotic processes are not completely understood. The present study tested the hypothesis that lysophosphatidylcholine (LPC), a proatherogenic component of oxLDL, induces endo…
View article: Aldosterone Negatively Regulates Nrf2 Activity: An Additional Mechanism Contributing to Oxidative Stress and Vascular Dysfunction by Aldosterone
Aldosterone Negatively Regulates Nrf2 Activity: An Additional Mechanism Contributing to Oxidative Stress and Vascular Dysfunction by Aldosterone Open
High levels of aldosterone (Aldo) trigger oxidative stress and vascular dysfunction independent of effects on blood pressure. We sought to determine whether Aldo disrupts Nrf2 signaling, the main transcriptional factor involved in antioxid…
View article: NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes
NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes Open
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β cells. We show here that the protein NOD-like receptor family pyrin domain containing 1 (NLRP1) has a key role in the pathogenesis of mouse and…
View article: Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome
Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome Open
Sepsis is a systemic inflammatory response syndrome (SIRS) resulting from a severe infection that is characterized by immune dysregulation, cardiovascular derangements, and end-organ dysfunction. The modification of proteins by O-linked N-…
View article: Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes
Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes Open
Background: NLRP3 inflammasome activation in response to several signals, including mitochondrial DNA (mDNA), regulates inflammatory responses by caspase-1 activation and interleukin-1β (IL-1β) release. Circulating mDNA is linked to micro …
View article: NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus
NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus Open
Aldosterone excess aggravates endothelial dysfunction in diabetes and hypertension by promoting the increased generation of reactive oxygen species, inflammation, and insulin resistance. Aldosterone activates the molecular platform inflamm…
View article: P8 O-GlcNAcylation Increases Constriction in Common Carotid Artery of Senescent-Accelerated Female Mice
P8 O-GlcNAcylation Increases Constriction in Common Carotid Artery of Senescent-Accelerated Female Mice Open
The glycosylation with O -linked- N -acetylglucosamine ( O -GlcNAc) is an enzymatic process found on nuclear and cytoplasmic proteins. Augmented levels of O -GlcNAc-modified proteins have been associated to cardiovascular disease (CD) in m…
View article: Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases Open
Free radicals act as secondary messengers, modulating a number of important biological processes, including gene expression, ion mobilization in transport systems, protein interactions and enzymatic functions, cell growth, cell cycle, redo…
View article: Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery
Activation of eNOS by D-pinitol Induces an Endothelium-Dependent Vasodilatation in Mouse Mesenteric Artery Open
D-pinitol is a cyclitol present in several edible plant species and extensively investigated for the treatment of metabolic diseases in humans, as food supplement, and demonstrated protective effects in the cardiovascular system. For these…
View article: Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome
Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome Open
Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT func…
View article: Pomegranate Extract Enhances Endothelium-Dependent Coronary Relaxation in Isolated Perfused Hearts from Spontaneously Hypertensive Ovariectomized Rats
Pomegranate Extract Enhances Endothelium-Dependent Coronary Relaxation in Isolated Perfused Hearts from Spontaneously Hypertensive Ovariectomized Rats Open
Decline in estrogen levels promotes endothelial dysfunction and, consequently, the most prevalent cardiovascular diseases in menopausal women. The use of natural therapies such as pomegranate can change these results. Pomegranate [Punica g…
View article: Obesity, Inflammation, and Exercise Training: Relative Contribution of iNOS and eNOS in the Modulation of Vascular Function in the Mouse Aorta
Obesity, Inflammation, and Exercise Training: Relative Contribution of iNOS and eNOS in the Modulation of Vascular Function in the Mouse Aorta Open
Background: The understanding of obsesity-related vascular dysfunction remains controversial mainly because of the diseases associated with vascular injury. Exercise training is known to prevent vascular dysfunction. Using an obesity model…