Josuel Ora
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View article: ABS0653 VALIDATION OF “CLINICAL RED FLAGS” FOR RA-ILD IN AN ITALIAN COHORT: THE ROLE OF DYSPNEA, COUGH AND CRACKLES
ABS0653 VALIDATION OF “CLINICAL RED FLAGS” FOR RA-ILD IN AN ITALIAN COHORT: THE ROLE OF DYSPNEA, COUGH AND CRACKLES Open
View article: Lungenfunktionstest: Einfache Interpretation in drei Schritten
Lungenfunktionstest: Einfache Interpretation in drei Schritten Open
Lungenfunktionstests (LuFu) sind für die Diagnose und Behandlung einer Vielzahl von Atemwegserkrankungen von entscheidender Bedeutung. Sie liefern wichtige Informationen über die Gesundheit der Lunge und helfen bei der Diagnose, der Beurte…
View article: Systematic Review and Meta-Analysis of the Application of T-PEP in the Therapeutic Management of COPD Patients
Systematic Review and Meta-Analysis of the Application of T-PEP in the Therapeutic Management of COPD Patients Open
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, characterized by chronic mucus hypersecretion (CMH) that exacerbates airway obstruction and accelerates disease progression. …
View article: β-Blockers and Asthma: Surprising findings from the FAERS database
β-Blockers and Asthma: Surprising findings from the FAERS database Open
Although the signals detected by disproportionality analysis are only candidate risks, the risk stratification resulting from our analysis highlights the need for cautious β-blocker selection in asthmatic patients or those predisposed to a…
View article: Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis
Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis Open
View article: Pulmonary Function Tests: Easy Interpretation in Three Steps
Pulmonary Function Tests: Easy Interpretation in Three Steps Open
Pulmonary function tests (PFTs) are pivotal in diagnosing and managing a broad spectrum of respiratory disorders. These tests provide critical insights into lung health, guiding diagnoses, assessing disease severity, and shaping patient ma…
View article: Exercise-Induced Asthma: Managing Respiratory Issues in Athletes
Exercise-Induced Asthma: Managing Respiratory Issues in Athletes Open
Asthma is a complex respiratory condition characterized by chronic airway inflammation and variable expiratory airflow limitation, affecting millions globally. Among athletes, particularly those competing at elite levels, the prevalence of…
View article: Hyperglycaemia and Chronic Obstructive Pulmonary Disease
Hyperglycaemia and Chronic Obstructive Pulmonary Disease Open
Chronic obstructive pulmonary disease (COPD) may coexist with type 2 diabetes mellitus (T2DM). Patients with COPD have an increased risk of developing T2DM compared with a control but, on the other side, hyperglycaemia and DM have been ass…
View article: Clinically Important Deterioration (CID) and Ageing in COPD: A Systematic Review and Meta-Regression Analysis According to PRISMA Statement
Clinically Important Deterioration (CID) and Ageing in COPD: A Systematic Review and Meta-Regression Analysis According to PRISMA Statement Open
This quantitative synthesis suggests that inhaled therapy is effective in reducing the risk of CID in COPD, although such a protective effect may be affected in older patients with impaired lung function. Further studies specifically desig…
View article: Effects of SARS-CoV-2 on Pulmonary Function and Muscle Strength Testing in Military Subjects According to the Period of Infection: Cross-Sectional Study
Effects of SARS-CoV-2 on Pulmonary Function and Muscle Strength Testing in Military Subjects According to the Period of Infection: Cross-Sectional Study Open
Background: Pulmonary function can be impaired as a long-term consequence of SARS-CoV-2 infection. The aim of this study was to evaluate the effect of SARS-CoV-2 infection on pulmonary function, exercise tolerance, and muscle strength in h…
View article: The BNT162b2 mRNA COVID-19 Vaccine Increases the Contractile Sensitivity to Histamine and Parasympathetic Activation in a Human Ex Vivo Model of Severe Eosinophilic Asthma
The BNT162b2 mRNA COVID-19 Vaccine Increases the Contractile Sensitivity to Histamine and Parasympathetic Activation in a Human Ex Vivo Model of Severe Eosinophilic Asthma Open
The BNT162b2 COVID-19 vaccine is composed of lipid-nanoparticles (LNP) containing the mRNA that encodes for SARS-CoV-2 spike glycoprotein. Bronchospasm has been reported as an early reaction after COVID-19 mRNA vaccines in asthmatic patien…
View article: Prolonged higher dose methylprednisolone<i>versus</i>conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS)
Prolonged higher dose methylprednisolone<i>versus</i>conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS) Open
Background Dysregulated systemic inflammation is the primary driver of mortality in severe coronavirus disease 2019 (COVID-19) pneumonia. Current guidelines favour a 7–10-day course of any glucocorticoid equivalent to dexamethasone 6 mg da…
View article: Effects of SARS-CoV-2 Infection on Pulmonary Function Tests and Exercise Tolerance
Effects of SARS-CoV-2 Infection on Pulmonary Function Tests and Exercise Tolerance Open
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to cause long-term pulmonary sequelae. Objects: The aim of this study was to evaluate the consequences of the SARS-CoV-2 infection on pulmonary funct…
View article: Comparing the Efficacy and Safety Profile of Triple Fixed-Dose Combinations in COPD: A Meta-Analysis and IBiS Score
Comparing the Efficacy and Safety Profile of Triple Fixed-Dose Combinations in COPD: A Meta-Analysis and IBiS Score Open
Background: Triple fixed-dose combination (FDC) therapy is recommended in severe chronic obstructive pulmonary disease (COPD) patients experiencing frequent exacerbations and/or symptoms not controlled by dual FDCs. Since no randomized con…
View article: Asthma and comorbidities: recent advances
Asthma and comorbidities: recent advances Open
Asthma is usually associated with pulmonary and extrapulmonary comorbidities that are more common in patients with severe asthma than in those with mild‑to‑moderate illness or in the general population. These comorbidities may affect the c…
View article: Efficacy of respiratory tele-rehabilitation in COPD patients: Systematic review and meta-analysis
Efficacy of respiratory tele-rehabilitation in COPD patients: Systematic review and meta-analysis Open
Pulmonary rehabilitation (PR) is a proven and effective intervention for chronic obstructive pulmonary disease (COPD). The recent pandemic has raised interest on new services, such as telerehabilitation (Tele-R). The aim of this study was …
View article: The future of inhalation therapy in chronic obstructive pulmonary disease
The future of inhalation therapy in chronic obstructive pulmonary disease Open
View article: Acute effect of oxygen therapy on exercise tolerance and dyspnea perception in ILD patients
Acute effect of oxygen therapy on exercise tolerance and dyspnea perception in ILD patients Open
Ambulatory oxygen therapy (AOT) is commonly prescribed in Interstitial Lung Disease (ILD) patients, with the aim of reducing dyspnea and increasing exercise tolerance. Despite its frequent use and a reasonable physiological rationale, ther…
View article: An Overview of the Safety and Efficacy of Monoclonal Antibodies for the Chronic Obstructive Pulmonary Disease
An Overview of the Safety and Efficacy of Monoclonal Antibodies for the Chronic Obstructive Pulmonary Disease Open
Several mAbs have been tested or are currently under clinical evaluation for the treatment of COPD. They can be subdivided into those that aim to block specific pro-inflammatory and pro-neutrophilic cytokines and chemokines, such as TNF-α,…
View article: Use of Thiols in the Treatment of COVID-19: Current Evidence
Use of Thiols in the Treatment of COVID-19: Current Evidence Open
View article: New Avenues for Phosphodiesterase Inhibitors in Asthma
New Avenues for Phosphodiesterase Inhibitors in Asthma Open
Many data indicate the potential benefits of PDE inhibitors as an add-on treatment especially in severe asthma due to their bronchodilator and/or anti-inflammatory activity, but no compound has yet reached the market as asthma treatment ma…
View article: Treatable Mechanisms in Asthma
Treatable Mechanisms in Asthma Open
Asthma is a heterogeneous condition, but firm identification of heterogeneity-focused treatments is still lacking. Dividing patients into subgroups of asthma pheno-/endotypes based on combined clinical and cellular biological characteristi…
View article: Happy hypoxemia, or blunted ventilation?
Happy hypoxemia, or blunted ventilation? Open
View article: <p>Long-Acting Muscarinic Antagonists Under Investigational to Treat Chronic Obstructive Pulmonary Disease</p>
Long-Acting Muscarinic Antagonists Under Investigational to Treat Chronic Obstructive Pulmonary Disease Open
Research on LAMA seems to have come to a standstill, the few new molecules under study do not show distinctive characteristics compared to the previous ones. Muscarinic antagonist/β2-agonist (MABAs) appear to be the major innovation curren…
View article: Guidance on nebulization during the current COVID-19 pandemic
Guidance on nebulization during the current COVID-19 pandemic Open
View article: Depressive and anxiety symptoms in patients with SARS-CoV2 infection
Depressive and anxiety symptoms in patients with SARS-CoV2 infection Open
View article: Dyspnea perception and neurological symptoms in non-severe COVID-19 patients
Dyspnea perception and neurological symptoms in non-severe COVID-19 patients Open
View article: Does bronchoscopy help the diagnosis in COVID-19 infection?
Does bronchoscopy help the diagnosis in COVID-19 infection? Open
This study evaluates the real value of using bronchoscopy to exclude the diagnosis of COVID-19 in patients with multiple negative nasal/oropharyngeal swabs https://bit.ly/2zmSgE8
View article: SMART and as-needed therapies in mild-to-severe asthma: a network meta-analysis
SMART and as-needed therapies in mild-to-severe asthma: a network meta-analysis Open
To date, there are no network meta-analyses comparing the impact of as-needed treatments in asthma, including the single maintenance and reliever therapy (known as “SMART” or “MART”; for simplicity, SMART will be used hereafter) and the us…
View article: Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection
Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection Open