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View article: Syringomyelia Associated with Magendie's Foramen Obstruction Due to Probably Congenital Gliomesenchymal Anomaly
Syringomyelia Associated with Magendie's Foramen Obstruction Due to Probably Congenital Gliomesenchymal Anomaly Open
We report a case of syringomyelia in a 55-year-old man with a unique obstruction of Magendie's foramen. Spinal magnetic resonance imaging revealed a large syrinx extending from C1 to C3, with intermittent syringomyelia extending down to Th…
View article: Near-Infrared Photoimmunotherapy in Brain Tumors—An Unexplored Frontier
Near-Infrared Photoimmunotherapy in Brain Tumors—An Unexplored Frontier Open
Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer treatment that uses near-infrared light to activate a conjugate of a monoclonal antibody (mAb) and a photoactivatable silica phthalocyanine dye (IRDye700DX: IR700). Unlike co…
View article: Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of <i>H3F3A</i> K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid
Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of <i>H3F3A</i> K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid Open
Introduction Leptomeningeal disease (LMD) in diffuse midline gliomas (DMGs) can lead to devastating symptoms such as severe pain, urinary incontinence, and tetraparesis, with limited treatment options. We determined whether detecting H3F3A…
View article: 10199- ET-16 NEAR-INFRARED PHOTOIMMUNOTHERAPY FOR THE TREATMENT OF MALIGNANT BRAIN TUMORS
10199- ET-16 NEAR-INFRARED PHOTOIMMUNOTHERAPY FOR THE TREATMENT OF MALIGNANT BRAIN TUMORS Open
BACKGROUND Near-infrared photoimmunotherapy (NIR-PIT) is a novel intraoperative local therapy. It involves a photosensitizer a near-infrared dye (IR700) conjugated to monoclonal antibodies targeting surface antigens of cancer cells. After …
View article: Reliable detection of genetic alterations in cyst fluid DNA for the diagnosis of brain tumors
Reliable detection of genetic alterations in cyst fluid DNA for the diagnosis of brain tumors Open
Purpose Liquid biopsy of cyst fluid in brain tumors has not been extensively studied to date. The present study was performed to see whether diagnostic genetic alterations found in brain tumor tissue DNA could also be detected in cell-free…
View article: Lysosomal acid lipase-activity as a novel target to efficiently address triple-negative breast cancer high malignancy
Lysosomal acid lipase-activity as a novel target to efficiently address triple-negative breast cancer high malignancy Open
Increased metabolism of neutral lipids, e.g. triglycerides and cholesterol esters, is a hallmark of malignant cancers such as triple-negative breast cancer (TNBC). Predominantly, cancer cells with a high epigenetic stem cell-associated sig…
View article: Preliminary Experience of Photodynamic Therapy for Malignant Gliomas and Shooting for Next-generation Treatment
Preliminary Experience of Photodynamic Therapy for Malignant Gliomas and Shooting for Next-generation Treatment Open
2018年7月に当科に光線力学療法（photodynamic therapy: PDT）を導入してから2021年6月まで，当科でPDTを施行した悪性脳腫瘍症例の臨床的特徴および無増悪生存期間（progression free survival: PFS），全生存期間（overall survival: OS），主な合併症について検討した．初発膠芽腫9例におけるPFSの中央値は14ヶ月，OS中央値は未達であった．死亡例は早期に遠隔再発を来した1例のみであった．主な合併症は光過…
View article: Diffusely Infiltrating Gliomas With Poor Prognosis, TERT Promotor Mutations, and Histological Anaplastic Pleomorphic Xanthoastrocytoma-Like Appearance Classify as Mesenchymal Type of Glioblastoma, IDH-wildtype by Methylation Analysis
Diffusely Infiltrating Gliomas With Poor Prognosis, TERT Promotor Mutations, and Histological Anaplastic Pleomorphic Xanthoastrocytoma-Like Appearance Classify as Mesenchymal Type of Glioblastoma, IDH-wildtype by Methylation Analysis Open
BACKGROUND: Pleomorphic xanthoastrocytoma (PXA) (World Health Organization grade II) is classified as a relatively benign and circumscribed glioma; however, anaplastic PXA (APXA, World Health Organization grade III) has a poorer prognosis,…
View article: ET-6 EFFICACY OF NEAR-INFRARED PHOTOIMMUNOTHERAPY TARGETING PODOPLANIN IN MALIGNANT GLIOMAS
ET-6 EFFICACY OF NEAR-INFRARED PHOTOIMMUNOTHERAPY TARGETING PODOPLANIN IN MALIGNANT GLIOMAS Open
Background Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment based on a conjugate of photosensitizer IR700 and an antibody which selectively binds to the surface antigen of cancer cells. Upon exposure to near infrared li…
View article: Epigenetic upregulation of Schlafen11 renders &#x2028;WNT- and SHH-activated medulloblastomas sensitive to cisplatin
Epigenetic upregulation of Schlafen11 renders 
WNT- and SHH-activated medulloblastomas sensitive to cisplatin Open
Background Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However, survival markedly differs among molecular subgroups and their biomarkers are unknown. Through…
View article: Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing a Dramatic Response to Methotrexate—Case Report
Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing a Dramatic Response to Methotrexate—Case Report Open
Background: Primary central nervous system lymphomas (PCNSLs) are sensitive to chemotherapy. The standard treatment is high-dose methotrexate (MTX)-based chemotherapy. There are no reports of successful treatment of acute uric acid nephrop…
View article: Meningoencephalocele in the Lateral Sphenoid Sinus Showing Malformation of Cortical Development: A Case Report
Meningoencephalocele in the Lateral Sphenoid Sinus Showing Malformation of Cortical Development: A Case Report Open
Meningoencephalocele in the lateral sphenoid sinus (SS) has been determined to be a rare entity often detected by cerebrospinal fluid (CSF) rhinorrhea. To date, the pathology of meningoencephalocele in the lateral SS has remained to be unc…
View article: Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing Dramatic Response to Methotrexate – Case Report
Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing Dramatic Response to Methotrexate – Case Report Open
Background: Primary central nervous system lymphomas (PCNSLs) are sensitive to chemotherapy. Standard treatment is high-dose methotrexate (MTX)-based chemotherapy. There are no reports of successful treatment of acute uric acid nephropathy…
View article: Novel Repositioning Therapy for Drug-Resistant Glioblastoma: In Vivo Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide
Novel Repositioning Therapy for Drug-Resistant Glioblastoma: In Vivo Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide Open
Multimodal therapy including surgery, radiation treatment, and temozolomide (TMZ) is performed on glioblastoma (GBM). However, the prognosis is still poor and there is an urgent need to develop effective treatments to improve survival. Mol…
View article: Novel Repositioning Therapy for Drug-Resistant Glioblastoma: <i>In</i> <i>vivo</i> Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide
Novel Repositioning Therapy for Drug-Resistant Glioblastoma: <i>In</i> <i>vivo</i> Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide Open
Multimodal therapy including surgery, radiation treatment and temozolomide (TMZ) is performed on glioblastoma (GBM). However, the prognosis is still poor and there is an urgent need to develop effective treatments to improve survival. Mole…
View article: Combination of Near-Infrared Photoimmunotherapy Using Trastuzumab and Small Protein Mimetic for HER2-Positive Breast Cancer
Combination of Near-Infrared Photoimmunotherapy Using Trastuzumab and Small Protein Mimetic for HER2-Positive Breast Cancer Open
Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer therapy based on a monoclonal antibody conjugated to a photosensitizer (IR700Dye) that is activated by near-infrared light irradiation. We previously reported on the use of N…
View article: Low Detection Rate of H3K27M Mutations in Cerebrospinal Fluid Obtained from Lumbar Puncture in Newly Diagnosed Diffuse Midline Gliomas
Low Detection Rate of H3K27M Mutations in Cerebrospinal Fluid Obtained from Lumbar Puncture in Newly Diagnosed Diffuse Midline Gliomas Open
Recent studies have suggested the feasibility of detecting H3K27M mutations in the cerebrospinal fluid of diffuse midline glioma (DMG) patients. However, cerebrospinal fluid from patients in these studies were collected mainly during biops…
View article: Hemodynamic features of an intracranial aneurysm rupture predicted by perianeurysmal edema: A case report
Hemodynamic features of an intracranial aneurysm rupture predicted by perianeurysmal edema: A case report Open
Background: Perianeurysmal edema (PAE) has been suggested as an indicator of potential aneurysm rupture; however, the hemodynamic features of these aneurysms are still unknown. A computational fluid dynamic (CFD) analysis was performed to …
View article: Anaplastic Pleomorphic Xanthoastrocytoma With Long-term Survival: An Autopsy Case Report
Anaplastic Pleomorphic Xanthoastrocytoma With Long-term Survival: An Autopsy Case Report Open
Background: The survival rate of anaplastic pleomorphic xanthoastrocytoma (APXA) is not well established due to the limited number of cases, but a few reports have suggested that the 5-year overall survival rate for APXA patients isaround …
View article: ACT-05 Present and future of precision-based medicine using cancer genome panels
ACT-05 Present and future of precision-based medicine using cancer genome panels Open
Background: Two cancer genome panels were approved for use in Japan in 2019, and their application in brain tumors are awaited. We have used CANCERPLEXR and FoundationOne CDx (F1) panels for the realization of precision-based medicine in b…
View article: Systematic review and meta-analysis on outcomes of salvage therapy in patients with tumour recurrence during ‘watch and wait’ in rectal cancer
Systematic review and meta-analysis on outcomes of salvage therapy in patients with tumour recurrence during ‘watch and wait’ in rectal cancer Open
Introduction The ‘watch and wait’ approach has recently emerged as an alternative approach for managing patients with complete clinical response in rectal cancer. However, less is understood whether the intervention is associated with a fa…
View article: Treatment Strategies for Infectious Intracranial Aneurysms: Report of Three Cases and Review of the Literature
Treatment Strategies for Infectious Intracranial Aneurysms: Report of Three Cases and Review of the Literature Open
We retrospectively reviewed the cases of three patients with infectious intracranial aneurysms (IIAs), and discuss the indications for surgical and endovascular treatments. We treated two men and one woman with a total of six aneurysms. Th…