Jothilingam Sivapackiam
YOU?
Author Swipe
View article: <i>Pseudomonas aeruginosa</i> infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection
<i>Pseudomonas aeruginosa</i> infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection Open
How pathogens inhibit transplant tolerance remains unclear. Here, we found that Pseudomonas aeruginosa infection, but not other common bacterial respiratory infections, increases antibody-mediated rejection (AMR) risk in recipients of lung…
View article: MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice Open
View article: Supplementary Methods from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Methods from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Additional details for methods and materials.
View article: Supplementary Figure S4 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S4 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
TEM quantitation of average area per mitochondrion and GO Biological Process GSEA in 4T1 cells.
View article: Supplementary Figure S2 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S2 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Validation of Itgb3 CRISPR knockout in 4T1 and PyMT-BO1 cells and assessment of docetaxel sensitivity in vitro and in vivo.
View article: Data from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Data from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Breast cancer bone metastases are common and incurable. Tumoral integrin β3 (β3) expression is induced through interaction with the bone microenvironment. Although β3 is known to promote bone colonization, its functional role during therap…
View article: Supplementary Figure S5 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S5 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
4T1 oxygen consumption rate on tissue culture-treated and poly-L-lysine-coated plates.
View article: Supplementary Methods from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Methods from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Additional details for methods and materials.
View article: Supplementary Figure S5 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S5 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
4T1 oxygen consumption rate on tissue culture-treated and poly-L-lysine-coated plates.
View article: Supplementary Figure S2 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S2 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Validation of Itgb3 CRISPR knockout in 4T1 and PyMT-BO1 cells and assessment of docetaxel sensitivity in vitro and in vivo.
View article: Supplementary Figure S3 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S3 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Docetaxel viability of hβ3-rescued β3KO1-BO1 cells compared to PyMT-BO1 in BMSC co-culture.
View article: Supplementary Figure S6 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S6 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Evaluation of cellular response to mTORC1 inhibition, BLI analysis of visceral metastases in PyMT-BO1 tumor-bearing mice receiving combination therapies, and αvβ3-NP-RAPA toxicity studies.
View article: Supplementary Figure S6 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S6 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Evaluation of cellular response to mTORC1 inhibition, BLI analysis of visceral metastases in PyMT-BO1 tumor-bearing mice receiving combination therapies, and αvβ3-NP-RAPA toxicity studies.
View article: Supplementary Figure S3 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S3 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Docetaxel viability of hβ3-rescued β3KO1-BO1 cells compared to PyMT-BO1 in BMSC co-culture.
View article: Data from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Data from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Breast cancer bone metastases are common and incurable. Tumoral integrin β3 (β3) expression is induced through interaction with the bone microenvironment. Although β3 is known to promote bone colonization, its functional role during therap…
View article: Supplementary Figure S4 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S4 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
TEM quantitation of average area per mitochondrion and GO Biological Process GSEA in 4T1 cells.
View article: Supplementary Figure S1 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S1 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Flow cytometric analysis of integrin β3 staining on breast cancer cells.
View article: Supplementary Figure S1 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Supplementary Figure S1 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Flow cytometric analysis of integrin β3 staining on breast cancer cells.
View article: MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy
MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy Open
Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD- UMOD ), one of the leading hereditary kidney diseases, and Alzheimer’s disease e…
View article: Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome
Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome Open
Albuminuria is a hallmark of glomerular disease of various etiologies. It is not only a symptom of glomerular disease but also a cause leading to glomerulosclerosis, interstitial fibrosis, and eventually, a decline in kidney function. The …
View article: Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases
Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases Open
Breast cancer bone metastases are common and incurable. Tumoral integrin β3 (β3) expression is induced through interaction with the bone microenvironment. Although β3 is known to promote bone colonization, its functional role during therap…
View article: Galuminox: Preclinical validation of a novel PET tracer for non-invasive imaging of oxidative stress in vivo
Galuminox: Preclinical validation of a novel PET tracer for non-invasive imaging of oxidative stress in vivo Open
View article: PET Radiopharmaceuticals for Imaging Chemotherapy-Induced Cardiotoxicity
PET Radiopharmaceuticals for Imaging Chemotherapy-Induced Cardiotoxicity Open
Purpose of Review Currently, cardiotoxicity is monitored through echocardiography or multigated acquisition scanning and is defined as 10% or higher LVEF reduction. The latter stage may represent irreversible myocardium injury and limits m…
View article: 68Ga-Galmydar: A PET imaging tracer for noninvasive detection of Doxorubicin-induced cardiotoxicity
68Ga-Galmydar: A PET imaging tracer for noninvasive detection of Doxorubicin-induced cardiotoxicity Open
68Ga-Galmydar could provide a noninvasive assessment of DOX-related and likely reversible metabolic changes at earliest stages. Further studies with other chemotherapeutics (potentially capable of inducing cardiomyopathy) are underway.
View article: <sup>67</sup>Ga-metalloprobes: monitoring the impact of geometrical isomers on accumulation profiles in rat cardiomyoblasts and human breast carcinoma cells
<sup>67</sup>Ga-metalloprobes: monitoring the impact of geometrical isomers on accumulation profiles in rat cardiomyoblasts and human breast carcinoma cells Open
67Ga-metalloprobes show uptake into rat cardiomyoblasts and human breast carcinoma cells, mediated by the delocalized positive charge on the molecular surface and hydrophobicity.
View article: CCDC 1496192: Experimental Crystal Structure Determination
CCDC 1496192: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 984596: Experimental Crystal Structure Determination
CCDC 984596: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: 67/68Galmydar: A metalloprobe for monitoring breast cancer resistance protein (BCRP)-mediated functional transport activity
67/68Galmydar: A metalloprobe for monitoring breast cancer resistance protein (BCRP)-mediated functional transport activity Open
View article: Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer’s disease
Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer’s disease Open