Jovan Mircetic
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View article: A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis
A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis Open
Glioblastoma (GBM) employs various strategies to resist therapy, resulting in poor patient survival. A key aspect of its survival mechanisms lies in metabolic regulation, maintaining rapid growth and evading cell death. Recent studies reve…
View article: Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome
Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome Open
View article: ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription
ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription Open
Rationale: Current therapies for metastatic osseous disease frequently fail to provide a durable treatment response. To date, there are only limited therapeutic options for metastatic prostate cancer, the mechanisms that drive the s…
View article: Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
Supplementary Data from Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
View article: Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
Supplementary Data from Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
View article: Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
Supplementary Data from Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
View article: Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
KRAS is the most frequently mutated oncogene in human cancer, and its activating mutations represent long-sought therapeutic targets. Programmable nucleases, particularly the CRISPR-Cas9 system, provide an attractive tool for geneti…
View article: Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
Supplementary Data from Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
View article: Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
Supplementary Data from Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
View article: Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Supplementary Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
Supplementary Data from Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
View article: Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Data from Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
KRAS is the most frequently mutated oncogene in human cancer, and its activating mutations represent long-sought therapeutic targets. Programmable nucleases, particularly the CRISPR-Cas9 system, provide an attractive tool for geneti…
View article: Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing
Efficient Correction of Oncogenic <i>KRAS</i> and <i>TP53</i> Mutations through CRISPR Base Editing Open
KRAS is the most frequently mutated oncogene in human cancer, and its activating mutations represent long-sought therapeutic targets. Programmable nucleases, particularly the CRISPR-Cas9 system, provide an attractive tool for genetically t…
View article: DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins
DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins Open
The programmable CRISPR/Cas9 DNA nuclease is a versatile genome editing tool, but it requires the host cell DNA repair machinery to alter genomic sequences. This fact leads to unpredictable changes of the genome at the cut sites. Genome ed…
View article: The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells
The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells Open
The RNA polymerase II (RNAPII) associated factor 1 complex (Paf1C) plays critical roles in modulating the release of paused RNAPII into productive elongation. However, regulation of Paf1C-mediated promoter-proximal pausing is complex and c…
View article: Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors
Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors Open
In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE) enable predefined nucleotide exchanges in genomic sequences without generating DNA double strand breaks. Here, we employed BE and PE mRNAs in conjunction…
View article: LncRNA <i>Panct1</i> Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1
LncRNA <i>Panct1</i> Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1 Open
View article: lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1
lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1 Open
View article: Development of a genetic sensor that eliminates p53 deficient cells
Development of a genetic sensor that eliminates p53 deficient cells Open
View article: Inactivation of Cancer Mutations Utilizing CRISPR/Cas9
Inactivation of Cancer Mutations Utilizing CRISPR/Cas9 Open
Although whole-genome sequencing has uncovered a large number of mutations that drive tumorigenesis, functional ratification for most mutations remains sparse. Here, we present an approach to test functional relevance of tumor mutations em…