Jowaher Alanazi
YOU?
Author Swipe
View article: Correlation of Pre-colonoscopy Blood Hemoglobin Levels With Significant Colorectal Pathology Among Fecal Immunochemical Test-Positive Patients
Correlation of Pre-colonoscopy Blood Hemoglobin Levels With Significant Colorectal Pathology Among Fecal Immunochemical Test-Positive Patients Open
View article: Generational Differences in Dietary Behaviours: A Cross-Sectional Study of Generations X, Y, and Z
Generational Differences in Dietary Behaviours: A Cross-Sectional Study of Generations X, Y, and Z Open
Background Dietary behaviours influence obesity and chronic disease. In Saudi Arabia, Westernised diets and sedentary lifestyles have driven rising obesity. This study explores generational dietary patterns to inform Saudi Vision 2030 plan…
View article: Comparative Analysis of Speckle-Tracking Echocardiography and Cardio-Specific Markers for Early Detection of Cardiotoxicity in Patients with Breast Cancer
Comparative Analysis of Speckle-Tracking Echocardiography and Cardio-Specific Markers for Early Detection of Cardiotoxicity in Patients with Breast Cancer Open
STE shows promise for early cardiotoxicity detection in BC patients undergoing chemotherapy due to its sensitivity and ability to assess myocardial mechanics. Integrating STE into cardiac monitoring can improve early detection and manageme…
View article: Correlation of rivaroxaban solubility in mixed solvents for optimization of solubility using machine learning analysis and validation
Correlation of rivaroxaban solubility in mixed solvents for optimization of solubility using machine learning analysis and validation Open
In this study, the solubility of rivaroxaban, a poorly water-soluble drug, was investigated in mixed solvent systems to address challenges in pharmaceutical formulation and bioavailability enhancement. Solubility optimization is essential …
View article: Computational models based on machine learning and validation for predicting ionic liquids viscosity in mixtures
Computational models based on machine learning and validation for predicting ionic liquids viscosity in mixtures Open
View article: Deciphering quinazoline derivatives’ interactions with EGFR: a computational quest for advanced cancer therapy through 3D-QSAR, virtual screening, and MD simulations
Deciphering quinazoline derivatives’ interactions with EGFR: a computational quest for advanced cancer therapy through 3D-QSAR, virtual screening, and MD simulations Open
Introduction The epidermal growth factor receptor (EGFR) presents a crucial target for combatting cancer mortality. Methods This study employs a suite of computational techniques, including 3D-QSAR, ligand-based virtual screening, molecula…
View article: A novel combination of machine learning models and metaheuristic algorithm to predict important parameters of twin screw wet granulation process
A novel combination of machine learning models and metaheuristic algorithm to predict important parameters of twin screw wet granulation process Open
Twin screw granulation (TSG) has recently been emerged as a novel approach for the continuous wet granulation of fine particles (i.e., powders) in the pharmaceutical industry. The presence of brilliant advantages like the ability of operat…
View article: Development of a novel machine learning approach to optimize important parameters for improving the solubility of an anti-cancer drug within green chemistry solvent
Development of a novel machine learning approach to optimize important parameters for improving the solubility of an anti-cancer drug within green chemistry solvent Open
Understanding the solubility of drug particles in solvents has remained a big challenge in different fields. Development of advanced computational methods to predict the solubility of drugs is an important necessity due to the difficulty a…
View article: Combination of an Oxindole Derivative with (−)-β-Elemene Alters Cell Death Pathways in FLT3/ITD+ Acute Myeloid Leukemia Cells
Combination of an Oxindole Derivative with (−)-β-Elemene Alters Cell Death Pathways in FLT3/ITD+ Acute Myeloid Leukemia Cells Open
Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options. Mutations in FLT3 tyrosine kinase receptors make the currently available therapies l…
View article: Application of different mathematical models based on artificial intelligence technique to predict the concentration distribution of solute through a polymeric membrane
Application of different mathematical models based on artificial intelligence technique to predict the concentration distribution of solute through a polymeric membrane Open
Membrane-based purification of therapeutic agents has recently attracted global attention as a promising replacement for conventional techniques like distillation and pervaporation. Despite the conduction of different investigations, devel…
View article: Advanced modeling and intelligence-based evaluation of pharmaceutical nanoparticle preparation using green supercritical processing: Theoretical assessment of solubility
Advanced modeling and intelligence-based evaluation of pharmaceutical nanoparticle preparation using green supercritical processing: Theoretical assessment of solubility Open
Modeling and simulations based on machine learning techniques were conducted in this research for determination of pharmaceutical solubility in supercritical solvent for the sake of green processing development in the area of pharmaceutics…
View article: Potential anti-obesity/inflammatory flavonoid-derived biomolecules against Obesity to prevent WAT differentiation by targeting a DNA-binding protein inhibitor, ID-1
Potential anti-obesity/inflammatory flavonoid-derived biomolecules against Obesity to prevent WAT differentiation by targeting a DNA-binding protein inhibitor, ID-1 Open
A concoction of unhealthy eating, inactivity, and the adverse effects of specific drugs brings on obesity. The primary cause of Obesity is the storage of too much energy and triglycerides in adipocytes, particularly white adipose tissue (W…
View article: Evaluating the Counseling Standards and Ability of Pharmacy Staff to Detect Antibiotic-Drugs Interactions: A Simulated Client Study from Pakistan
Evaluating the Counseling Standards and Ability of Pharmacy Staff to Detect Antibiotic-Drugs Interactions: A Simulated Client Study from Pakistan Open
Effective and safe medication use can be maximized by providing medication counseling, which aims to optimize therapeutic results. This approach improves the effectiveness of antibacterial treatment, reduces treatment expenses, and mitigat…
View article: Computational and In Vitro Assessment of a Natural Triterpenoid Compound Gedunin against Breast Cancer via Caspase 3 and Janus Kinase/STAT Modulation
Computational and In Vitro Assessment of a Natural Triterpenoid Compound Gedunin against Breast Cancer via Caspase 3 and Janus Kinase/STAT Modulation Open
Breast cancer is the most prevalent type of malignancy among females as per the report of the World Health Organization. There are several established chemotherapeutic regimes for the clinical management of different solid cancers; however…
View article: Validation of a Novel RP-HPLC Technique for Simultaneous Estimation of Lignocaine Hydrochloride and Tibezonium Iodide: Greenness Estimation Using AGREE Penalties
Validation of a Novel RP-HPLC Technique for Simultaneous Estimation of Lignocaine Hydrochloride and Tibezonium Iodide: Greenness Estimation Using AGREE Penalties Open
Herein, we reported an HPLC method for the simultaneous determination of tibezonium iodide (TBN) and lignocaine hydrochloride (LGN). The method was developed according to the International Conference for Harmonization guidelines (ICH) Q2R1…
View article: DFT study of carboplatin encapsulation interactions with carboxylated carbon nanotubes and conjugated to folic acid for targeted nano delivery systems
DFT study of carboplatin encapsulation interactions with carboxylated carbon nanotubes and conjugated to folic acid for targeted nano delivery systems Open
In this study, a nano-drug delivery design based on (8, 8) carboxylated single-walled carbon nanotube (CNT-COOH) and folic acid (FA) decorated on CNT-COOH (CNT-FA) were investigated. These nanocarriers were applied to enhance therapeutic e…
View article: Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins
Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins Open
Enterococci are troublesome nosocomial, opportunistic Gram-positive cocci bacteria showing enhanced resistance to many commonly used antibiotics. This study aims to investigate the prevalence and genetic basis of antibiotic resistance to m…
View article: Drug Repurposing: A New Hope in Drug Discovery for Prostate Cancer
Drug Repurposing: A New Hope in Drug Discovery for Prostate Cancer Open
Prostate cancer (PCA), the most common cancer in men, accounted for 1.3 million new incidences in 2018. An increase in incidences is an issue of concern that should be addressed. Of all the reported prostate cancers, 85% were detected in s…
View article: 3-Methoxy Carbazole Impedes the Growth of Human Breast Cancer Cells by Suppressing NF-κB Signaling Pathway
3-Methoxy Carbazole Impedes the Growth of Human Breast Cancer Cells by Suppressing NF-κB Signaling Pathway Open
Breast cancer represents the most frequently occurring cancer globally among women. As per the recent report of the World Health Organization (WHO), it was documented that by the end of the year 2020, approximately 7.8 million females were…
View article: Prevalence of pharmacological and non-pharmacological coping mechanisms for anxiety management during the COVID-19 pandemic: investigating the transition to online learning among medical students
Prevalence of pharmacological and non-pharmacological coping mechanisms for anxiety management during the COVID-19 pandemic: investigating the transition to online learning among medical students Open
View article: Can Natural Products Targeting EMT Serve as the Future Anticancer Therapeutics?
Can Natural Products Targeting EMT Serve as the Future Anticancer Therapeutics? Open
Cancer is the leading cause of death and has remained a big challenge for the scientific community. Because of the growing concerns, new therapeutic regimens are highly demanded to decrease the global burden. Despite advancements in chemot…
View article: Farnesiferol C Exerts Antiproliferative Effects on Hepatocellular Carcinoma HepG2 Cells by Instigating ROS-Dependent Apoptotic Pathway
Farnesiferol C Exerts Antiproliferative Effects on Hepatocellular Carcinoma HepG2 Cells by Instigating ROS-Dependent Apoptotic Pathway Open
Farnesiferol C (Far-C) is a coumarin commonly extracted from Ferula asafetida and is popularly used as a traditional source of natural remedy. Liver cancer or hepatocellular carcinoma (HCC) has emerged as a major cause behind cancer burden…