Explanipedia

Operational approaches and recommendations to interrupt transmission of Mycobacterium leprae Open

Wim H. van Brakel, Bouke C. de Jong, Jayashree P. Kunju, Neeraj Mistry, Alice Cruz , et al. · 2025

Vaping during pregnancy: a systematic review of health outcomes Open

Michael Ussher, Joy Fleming, Leonie S. Brose · 2024

Introduction Smoking during pregnancy is harmful to maternal and child health. Vaping is used for smoking cessation but evidence on health effects during pregnancy is scarce. We conducted a systematic review of health outcomes of vaping du…

Vaping during pregnancy: A systematic review of health outcomes Open

Michael Ussher, Joy Fleming, Leonie S. Brose · 2024

Introduction Smoking during pregnancy is harmful to maternal and child health; vaping is used for smoking cessation but evidence on health effects during pregnancy is scarce. We conducted a systematic review of health outcomes of vaping du…

EspB and HtpG interact with the type III-A CRISPR/Cas system of Mycobacterium tuberculosis Open

Mingmin Shi, Hongtai Zhang, Joy Fleming, Wenjing Wei, Hong Chen , et al. · 2023

Introduction: Mycobacterium tuberculosis (MTB) has a type III-A clustered regularly interspaced short palindromic repeat/CRISPR-associated protein (CRISPR/Cas) system consisting of a Csm1-5 and CRISPR RNA (crRNA) complex involved in the de…

Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene Open

Li Wan, Peilei Hu, Lili Zhang, Zhao‐Xi Wang, Joy Fleming , et al. · 2023

CD84 is a Suppressor of T and B Cell Activation during Mycobacterium tuberculosis Pathogenesis Open

Nan Zheng, Joy Fleming, Peilei Hu, Jianjian Jiao, Zhang Guo-qin , et al. · 2022

Immune checkpoint therapies, such as targeting checkpoints like PD-1/PD-L1, have proved successful in cancer therapy and can reinvigorate immune responses. The potential of this approach for treating chronic infectious diseases like TB has…

M. tuberculosis CRISPR/Cas proteins are secreted virulence factors that trigger cellular immune responses Open

Jianjian Jiao, Nan Zheng, Wenjing Wei, Joy Fleming, Xingyun Wang , et al. · 2021

The role of prokaryotic CRISPR/Cas system proteins as a defensive shield against invasive nucleic acids has been studied extensively. Non-canonical roles in pathogenesis involving intracellular targeting of certain virulence-associated end…

relA Inactivation Converts Sulfonamides Into Bactericidal Compounds Open

Lizhen Si, Jing Gu, Mi Wen, Ruiqi Wang, Joy Fleming , et al. · 2021

Folates are required for the de novo biosynthesis of purines, thymine, methionine, glycine, and pantothenic acid, key metabolites that bacterial cells cannot survive without. Sulfonamides, which inhibit bacterial folate biosynthesis and ar…

Systematic Evaluation of Mycobacterium tuberculosis Proteins for Antigenic Properties Identifies Rv1485 and Rv1705c as Potential Protective Subunit Vaccine Candidates Open

Yaguo Wang, Zihui Li, Shucai Wu, Joy Fleming, Chuanyou Li , et al. · 2020

The lack of efficacious vaccines against Mycobacterium tuberculosis (MTB) infection is a limiting factor in the prevention and control of tuberculosis (TB), the leading cause of death from an infectious agent. Improvement or replacement of…

Mycobacterium smegmatis MSMEG_0129 is a nutrition-associated regulator that interacts with CarD and ClpP2 Open

Ying Zhou, Wenjing Wei, Joy Fleming, Chen Ye, Shuping Zheng , et al. · 2020

Mycobacterium smegmatis MSMEG_0129 and Rv0164, its homologue in Mycobacterium tuberculosis, are single START-domain proteins essential for bacterial growth and survival, but their biochemical activities and biological roles remain undeterm…

Rare cause of Peritoneal Dialysis–Related Peritonitis in a child: Abiotrophi defectiva Open

Juanjuan Zhou, Yang Jun-wen, Kaijie Gao, Joy Fleming, Junmei Yang · 2019

Background: Abiotrophia defective is a frequently reported clinical infection; however, it is rarely implicated in peritoneal dialysis–related infections in peritonitis patients. Case presentation: We report a rare case of peritoneal dialy…

Extending health messaging to the consumption experience: a focus group study exploring smokers’ perceptions of health warnings on cigarettes Open

Crawford Moodie, Rachel O’Donnell, Joy Fleming, Richard Purves, Jennifer McKell , et al. · 2019

Introduction: While most countries require health warnings on cigarette packs, the Scottish and Canadian Governments are considering requiring health warnings on cigarette sticks. Methods: Twenty focus groups were conducted i…

Retrospective Analysis of False-Positive and Disputed Rifampin Resistance Xpert MTB/RIF Assay Results in Clinical Samples from a Referral Hospital in Hunan, China Open

Peilei Hu, Hongtai Zhang, Joy Fleming, Guofeng Zhu, Shuai Zhang , et al. · 2019

Concerns about the specificity of the Xpert MTB/RIF (Xpert) assay have arisen, as false-positive errors in the determination of Mycobacterium tuberculosis complex (MTBC) infection and rifampin (RIF) resistance in clinical practice have bee…

Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis Open

Shuping Zheng, Ying Zhou, Joy Fleming, Ya‐Feng Zhou, Mengting Zhang , et al. · 2018

Mycobacterium tuberculosis is a notorious pathogen that continues to threaten human health. Rv0164, an antigen of both T‐ and B cells conserved across mycobacteria, and MSMEG _0129, its close homolog in Mycobacterium smegmatis , are predic…

Dataset for: Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis Open

Shuping Zheng, Ying Zhou, Joy Fleming, Ya‐Feng Zhou, Mengting Zhang , et al. · 2018

Mycobacterium tuberculosis, a notorious pathogen, still threatens human health. Rv0164, an antigen of both T- and B-cells conserved across the mycobacteria, and MSMEG_0129, its close homolog in Mycobacterium smegmatis, are pr…

A standardised method for interpreting the association between mutations and phenotypic drug resistance inMycobacterium tuberculosis Open

Paolo Miotto, Belay Tessema, Elisa Tagliani, Leonid Chindelevitch, Angela M. Starks , et al. · 2017

A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence. Raw genotype–phenotype corr…

Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis Open

Yunrong Gao, De‐Feng Li, Joy Fleming, Ya‐Feng Zhou, Ying Liu , et al. · 2017

MarR family proteins are transcriptional regulators that control expression of bacterial proteins involved in metabolism, virulence, stress responses and multi-drug resistance, mainly via ligand-mediated attenuation of DNA binding. Greater…

Crystal structure of Rv3899c184–410, a hypothetical protein fromMycobacterium tuberculosis Open

Yingying Liu, Yunrong Gao, De‐Feng Li, Joy Fleming, Honglin Li , et al. · 2016

Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; howeve…

An automated approach for global identification of sRNA-encoding regions in RNA-Seq data from <italic>Mycobacterium tuberculosis</italic> Open

Ming Wang, Joy Fleming, Zihui Li, Chuanyou Li, Hongtai Zhang , et al. · 2016

Deep-sequencing of bacterial transcriptomes using RNA-Seq technology has made it possible to identify small non-coding RNAs, RNA molecules which regulate gene expression in response to changing environments, on a genome-wide scale in an ev…

The β2 clamp in the Mycobacterium tuberculosis DNA polymerase III αβ2ε replicase promotes polymerization and reduces exonuclease activity Open

Shoujin Gu, Wenjuan Li, Hongtai Zhang, Joy Fleming, Weiqiang Yang , et al. · 2016

DNA polymerase III (DNA pol III) is a multi-subunit replication machine responsible for the accurate and rapid replication of bacterial genomes, however, how it functions in Mycobacterium tuberculosis ( Mtb ) requires further investigation…

Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 fromMycobacterium tuberculosis Open

Xiaoqian Xie, Xiaoli Zhang, Chao Qi, De‐Feng Li, Joy Fleming , et al. · 2016

The protein EccB1, a core component of the type VII secretion system (T7SS) of Mycobacterium tuberculosis , has been identified as an ATPase and is essential for the secretion of virulence factors by the ESX-1 system. In a previous study, …

Cytokine and Antibody Based Diagnostic Algorithms for Sputum Culture-Positive Pulmonary Tuberculosis Open

Tao Chen, Jin‐Fei Lin, Wei Wang, Joy Fleming, Liang Chen , et al. · 2015

Our results show that combining detection of TB-related cytokines and TB-specific antibodies significantly enhances diagnostic accuracy for active TB, providing greater accuracy than conventional diagnostic methods such as interferon gamma…

Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria Open

Wenjuan Li, Shoujin Gu, Joy Fleming, Lijun Bi · 2015

Fatty acid degradation protein D32 (FadD32), an enzyme required for mycolic acid biosynthesis and essential for mycobacterial growth, has recently been identified as a valid and promising target for anti-tuberculosis drug development. Here…

Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells* Open

Peng Zheng, Qian Xiong, Ying Wu, Ying Chen, Zhuo Chen , et al. · 2015

Long noncoding RNAs (lncRNAs), which have emerged in recent years as a new and crucial layer of gene regulators, regulate various biological processes such as carcinogenesis and metastasis. HOTAIR (Hox transcript antisense intergenic RNA),…

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