Elizabeth Rivers
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View article: Combination therapy of favipiravir and nitazoxanide to treat respiratory viral infections in severe T-cell deficient children: A single centre experience
Combination therapy of favipiravir and nitazoxanide to treat respiratory viral infections in severe T-cell deficient children: A single centre experience Open
View article: Immunogenicity and Safety of Heterologous Omicron BA.1 and Bivalent SARS-CoV-2 Recombinant Spike Protein Booster Vaccines: A Phase 3 Randomized Clinical Trial
Immunogenicity and Safety of Heterologous Omicron BA.1 and Bivalent SARS-CoV-2 Recombinant Spike Protein Booster Vaccines: A Phase 3 Randomized Clinical Trial Open
Background Mutations present in emerging SARS-CoV-2 variants permit evasion of neutralization with prototype vaccines. A novel Omicron BA.1 subvariant–specific vaccine (NVX-CoV2515) was tested alone or as a bivalent preparation with the pr…
View article: Immunogenicity and safety of heterologous Omicron BA.1 and bivalent SARS-CoV-2 recombinant spike protein booster vaccines: a phase 3, randomized, clinical trial
Immunogenicity and safety of heterologous Omicron BA.1 and bivalent SARS-CoV-2 recombinant spike protein booster vaccines: a phase 3, randomized, clinical trial Open
Background Mutations present in emerging SARS-CoV-2 variants permit evasion of neutralization with prototype vaccines. A novel Omicron BA.1 subvariant-specific vaccine (NVX-CoV2515) was tested alone, or as a bivalent preparation in combina…
View article: Safety and Efficacy of the NVX-CoV2373 Coronavirus Disease 2019 Vaccine at Completion of the Placebo-Controlled Phase of a Randomized Controlled Trial
Safety and Efficacy of the NVX-CoV2373 Coronavirus Disease 2019 Vaccine at Completion of the Placebo-Controlled Phase of a Randomized Controlled Trial Open
Background The recombinant protein-based vaccine, NVX-CoV2373, demonstrated 89.7% efficacy against coronavirus disease 2019 (COVID-19) in a phase 3, randomized, observer-blinded, placebo-controlled trial in the United Kingdom. The protocol…
View article: Safety, Immunogenicity, and Efficacy of a COVID-19 Vaccine (NVX-CoV2373) Co-administered With Seasonal Influenza Vaccines
Safety, Immunogenicity, and Efficacy of a COVID-19 Vaccine (NVX-CoV2373) Co-administered With Seasonal Influenza Vaccines Open
Summary Background The safety and immunogenicity profile of COVID-19 vaccines when administered concomitantly with seasonal influenza vaccines has not yet been reported. Methods A sub-study on influenza vaccine co-administration was conduc…
View article: Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis
Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis Open
Prostate cancer (PCa) constitutes a serious health challenge and remains one of the main causes of cancer-related death among men. The more aggressive form of the disease has been attributed to androgen independence, resulting in a lack of…
View article: IL‐18: A potential inflammation biomarker in Wiskott–Aldrich syndrome
IL‐18: A potential inflammation biomarker in Wiskott–Aldrich syndrome Open
Analysis of serum cytokine levels in Wiskott-Aldrich syndrome patients pre- and post- treatment reveals IL-18 as a stable and reliable marker of inflammation. Definitive stem cell treatment with good myeloid correction correlates with reso…
View article: Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells
Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells Open
The actin cytoskeletal regulator Wiskott Aldrich syndrome protein (WASp) has been implicated in maintenance of the autophagy-inflammasome axis in innate murine immune cells. Here, we show that WASp deficiency is associated with impaired ra…
View article: Author response: Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells
Author response: Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells Open
View article: Absent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in folliculin-interacting protein 1 deficiency
Absent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in folliculin-interacting protein 1 deficiency Open
Agammaglobulinemia is the most profound primary antibody deficiency that can occur due to an early termination of B-cell development. We here investigated 3 novel patients, including the first known adult, from unrelated families with agam…
View article: Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome
Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome Open
View article: Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort Open
View article: Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Whole-genome sequencing of a sporadic primary immunodeficiency cohort Open
View article: Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells
Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells Open
The actin cytoskeletal regulator Wiskott Aldrich syndrome protein (WASp) has been implicated in maintenance of the autophagy-inflammasome axis in innate murine immune cells. Here, we show that WASp deficiency is associated with impaired ra…
View article: How I manage patients with Wiskott Aldrich syndrome
How I manage patients with Wiskott Aldrich syndrome Open
Summary Wiskott Aldrich syndrome (WAS) is a primary immunodeficiency disease resulting in recurrent infections, eczema and microthrombocytopaenia. In its classical form, significant combined immune deficiency, autoimmune complications and …
View article: Whole genome sequencing of a sporadic primary immunodeficiency cohort
Whole genome sequencing of a sporadic primary immunodeficiency cohort Open
Primary immunodeficiency (PID) is characterised by recurrent and often life-threatening infections, autoimmunity and cancer, and it presents major diagnostic and therapeutic challenges. Although the most severe forms present in early child…
View article: Bleeding and splenectomy in Wiskott-Aldrich syndrome: A single-centre experience
Bleeding and splenectomy in Wiskott-Aldrich syndrome: A single-centre experience Open
View article: Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells Open
View article: Contents: Eur. J. Immunol. 11'17
Contents: Eur. J. Immunol. 11'17 Open
View article: Wiskott‐Aldrich syndrome protein: Emerging mechanisms in immunity
Wiskott‐Aldrich syndrome protein: Emerging mechanisms in immunity Open
The Wiskott–Aldrich syndrome protein (WASP) participates in innate and adaptive immunity through regulation of actin cytoskeleton‐dependent cellular processes, including immune synapse formation, cell signaling, migration and cytokine rele…