Joyce E. Johnson
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View article: Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules
Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules Open
The diagnostic accuracy of navigational bronchoscopy was noninferior to that of transthoracic needle biopsy among patients with peripheral pulmonary nodules measuring 10 to 30 mm. (Funded by Medtronic and others; VERITAS ClinicalTrials.gov…
View article: Intraoperative Evaluation of Pediatric Bone and Soft Tissue Lesions: Retrospective Analysis of 595 Frozen Sections With Emphasis on Discrepancy and Diagnostic Pitfalls
Intraoperative Evaluation of Pediatric Bone and Soft Tissue Lesions: Retrospective Analysis of 595 Frozen Sections With Emphasis on Discrepancy and Diagnostic Pitfalls Open
Context.— Frozen section (FS) evaluation of pediatric bone and soft tissue (BST) lesions is infrequently encountered and may pose considerable diagnostic challenges. Limited data exist about the accuracy and related diagnostic difficulties…
View article: A novel case report of isolated cardiac myxedematosus
A novel case report of isolated cardiac myxedematosus Open
Background Cardiac mucinous deposits are a rare entity only previously described in the setting of scleromyxedema, a disorder characterized by cutaneous and systemic mucin deposits, fibroblastic proliferation, and monoclonal gammopathies. …
View article: Pulmonary vascular disease in Veterans with post-deployment respiratory syndrome
Pulmonary vascular disease in Veterans with post-deployment respiratory syndrome Open
Exertional dyspnea has been documented in US military personnel after deployment to Iraq and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associated with pulmonary vascular disease (PVD). We pe…
View article: Navigational Bronchoscopy vs CT Scan-Guided Transthoracic Needle Biopsy for the Diagnosis of Indeterminate Lung Nodules
Navigational Bronchoscopy vs CT Scan-Guided Transthoracic Needle Biopsy for the Diagnosis of Indeterminate Lung Nodules Open
Background: Lung nodule incidence is increasing. Many nodules require biopsy to discriminate between benign and malignant causes. The gold standard for minimally invasive biopsy, CT scan-guided transthoracic needle biopsy (CT-TTNB), has no…
View article: Pulmonary Vascular Disease in Veterans with Post-Deployment Respiratory Syndrome
Pulmonary Vascular Disease in Veterans with Post-Deployment Respiratory Syndrome Open
Background Increased frequency of exertional dyspnea has been documented in U.S. military personnel after deployment to Southwest Asia and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associate…
View article: Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease
Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease Open
Although profibrotic cytokines, such as IL-17A and TGF-β1, have been implicated in the pathogenesis of interstitial lung disease (ILD), the interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic c…
View article: Low Gut Microbial Diversity Augments Estrogen-driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease
Low Gut Microbial Diversity Augments Estrogen-driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease Open
Although profibrotic cytokines such as IL-17A and TGF-β1 have been implicated in interstitial lung disease (ILD) pathogenesis, interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic cytokine expre…
View article: Clinicopathological and Treatment Patterns of Combined Small-Cell Lung Carcinoma with Future Insight to Treatment: A Population-Based Study
Clinicopathological and Treatment Patterns of Combined Small-Cell Lung Carcinoma with Future Insight to Treatment: A Population-Based Study Open
Background: Primary lung cancer is the most common cause of cancer-related mortality in the United States (US). Approximately 90% of lung cancers are associated with smoking and the use of other tobacco products. Based on histology, lung c…
View article: Gut microbiota modulates lung fibrosis severity following acute lung injury in mice
Gut microbiota modulates lung fibrosis severity following acute lung injury in mice Open
Independent studies demonstrate the significance of gut microbiota on the pathogenesis of chronic lung diseases; yet little is known regarding the role of the gut microbiota in lung fibrosis progression. Here we show, using the bleomycin m…
View article: Characterization of Immunopathology and Small Airway Remodeling in Constrictive Bronchiolitis
Characterization of Immunopathology and Small Airway Remodeling in Constrictive Bronchiolitis Open
Rationale: Constrictive bronchiolitis (ConB) is a relatively rare and understudied form of lung disease whose underlying immunopathology remains incompletely defined. Objectives: Our objectives were to quantify specific pathological featur…
View article: Nondiagnostic category of Milan System for Reporting Pediatric Salivary Gland Cytopathology: outcomes and root cause analysis
Nondiagnostic category of Milan System for Reporting Pediatric Salivary Gland Cytopathology: outcomes and root cause analysis Open
BACKGROUND Fine‐needle aspiration (FNA) results classified as the nondiagnostic category of the Milan system for reporting salivary gland cytopathology (MSRSGC) may be infrequently encountered in children. Clinical management may be challe…
View article: Fine-Needle Aspiration Biopsy of Pediatric Salivary Gland Tumors: Analysis of Patient Tolerability, Sedation Requirement, and Procedural Complication
Fine-Needle Aspiration Biopsy of Pediatric Salivary Gland Tumors: Analysis of Patient Tolerability, Sedation Requirement, and Procedural Complication Open
Objective: Fine-needle aspiration (FNA) biopsy is the standard diagnostic tool recommended by consensus management guidelines for preoperative evaluation of salivary gland tumors in adults. However, its utility in the pediatric population …
View article: Fatal enhanced respiratory syncytial virus disease in toddlers
Fatal enhanced respiratory syncytial virus disease in toddlers Open
Fatal enhanced respiratory syncytial virus disease in toddlers has distinctive immune and transcriptional features.
View article: CD19 + CD21lo/neg cells are increased in systemic sclerosis-associated interstitial lung disease
CD19 + CD21lo/neg cells are increased in systemic sclerosis-associated interstitial lung disease Open
Interstitial lung disease (ILD) represents a significant cause of morbidity and mortality in systemic sclerosis (SSc). The purpose of this study was to examine recirculating lymphocytes from SSc patients for potential biomarkers of interst…
View article: Postdeployment Respiratory Syndrome in Soldiers With Chronic Exertional Dyspnea
Postdeployment Respiratory Syndrome in Soldiers With Chronic Exertional Dyspnea Open
After deployment to Southwest Asia, some soldiers develop persistent respiratory symptoms, including exercise intolerance and exertional dyspnea. We identified 50 soldiers with a history of deployment to Southwest Asia who presented with u…
View article: Application of the Milan System for Reporting Pediatric Salivary Gland Cytopathology: Analysis of histologic follow‐up, risk of malignancy, and diagnostic accuracy
Application of the Milan System for Reporting Pediatric Salivary Gland Cytopathology: Analysis of histologic follow‐up, risk of malignancy, and diagnostic accuracy Open
Background The diagnosis and management of salivary gland tumors in pediatric patients can be challenging. The utility of fine‐needle aspiration (FNA) cytopathology and the performance of the Milan System for Reporting Salivary Gland Cytop…
View article: Persistent focal pulmonary opacity elucidated by transbronchial cryobiopsy: a case for larger biopsies
Persistent focal pulmonary opacity elucidated by transbronchial cryobiopsy: a case for larger biopsies Open
Persistent pulmonary opacities associated with respiratory symptoms that progress despite medical treatment present a diagnostic dilemma for pulmonologists. We describe the case of a 37‐year‐old woman presenting with progressive fatigue, s…
View article: PD-1 up-regulation on CD4 <sup>+</sup> T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production
PD-1 up-regulation on CD4 <sup>+</sup> T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production Open
PD-1 + T H 17 cells enhance collagen-1 production from human lung fibroblasts.
View article: Transbronchial Cryobiopsy Can Diagnose Constrictive Bronchiolitis in Veterans of Recent Conflicts in the Middle East
Transbronchial Cryobiopsy Can Diagnose Constrictive Bronchiolitis in Veterans of Recent Conflicts in the Middle East Open
Transbronchial lung biopsy with a cryoprobe, or cryobiopsy, provides larger tissue samples than traditional forceps biopsy (1, 2).Investigations of this technique in diffuse parenchymal lung diseases have reported favorable results, with d…
View article: Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes
Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes Open
Lipid droplets are intracellular energy storage organelles composed of a hydrophobic core of neutral lipid, surrounded by a monolayer of phospholipid and a diverse array of proteins. The function of the vast majority of these proteins with…