Joyce Mhlanga
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View article: Comparability of Quantifying Relative Lung Ventilation with Inhaled<sup>99m</sup>Tc-Technegas and<sup>133</sup>Xe in Patients Undergoing Evaluation for Lung Transplantation
Comparability of Quantifying Relative Lung Ventilation with Inhaled<sup>99m</sup>Tc-Technegas and<sup>133</sup>Xe in Patients Undergoing Evaluation for Lung Transplantation Open
99mTc-Technegas was recently approved by the U.S. Food and Drug Administration as a radiopharmaceutical for ventilation scintigraphy. However, there are currently no data comparing the quantification of relative lung ventilation with 99mTc…
View article: Need for Objective Task-Based Evaluation of Image Segmentation Algorithms for Quantitative PET: A Study with ACRIN 6668/RTOG 0235 Multicenter Clinical Trial Data
Need for Objective Task-Based Evaluation of Image Segmentation Algorithms for Quantitative PET: A Study with ACRIN 6668/RTOG 0235 Multicenter Clinical Trial Data Open
Reliable performance of PET segmentation algorithms on clinically relevant tasks is required for their clinical translation. However, these algorithms are typically evaluated using figures of merit (FoMs) that are not explicitly designed t…
View article: LUNG STAGING IN PEDIATRIC HODGKIN LYMPHOMA: STAGING EVALUATION & RESPONSE CRITERIA HARMONIZATION FOR CHILDHOOD, ADOLESCENT & YOUNG ADULT HL (SEARCH FOR CAYAHL) CONSENSUS
LUNG STAGING IN PEDIATRIC HODGKIN LYMPHOMA: STAGING EVALUATION & RESPONSE CRITERIA HARMONIZATION FOR CHILDHOOD, ADOLESCENT & YOUNG ADULT HL (SEARCH FOR CAYAHL) CONSENSUS Open
Introduction: Staging of lung lesions in pediatric Hodgkin lymphoma (HL) is a long standing, controversial issue. Consortium groups define lung involvement and its distinction from E-lesions differently. Application of these criteria to in…
View article: Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C
Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C Open
Background National Cancer Institute-Children’s Oncology Group Pediatric Molecular Analysis for Therapy Choice assigns patients aged 1-21 years with refractory solid tumors, brain tumors, lymphomas, and histiocytic disorders to phase II tr…
View article: Need for objective task-based evaluation of AI-based segmentation methods for quantitative PET
Need for objective task-based evaluation of AI-based segmentation methods for quantitative PET Open
Artificial intelligence (AI)-based methods are showing substantial promise in segmenting oncologic positron emission tomography (PET) images. For clinical translation of these methods, assessing their performance on clinically relevant tas…
View article: Observer-study-based approaches to quantitatively evaluate the realism of synthetic medical images
Observer-study-based approaches to quantitatively evaluate the realism of synthetic medical images Open
Objective. Synthetic images generated by simulation studies have a well-recognized role in developing and evaluating imaging systems and methods. However, for clinically relevant development and evaluation, the synthetic images must be cli…
View article: Imaging of pediatric hematopoietic stem cell transplant recipients: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Imaging of pediatric hematopoietic stem cell transplant recipients: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper Open
Imaging in hematopoietic stem cell transplantation patients is not targeted at evaluating the transplant per se. Rather, imaging is largely confined to evaluating peri‐procedural and post‐procedural complications. Alternatively, imaging ma…
View article: Imaging of pediatric thyroid tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Imaging of pediatric thyroid tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper Open
Pediatric thyroid cancer is rare in children; however, incidence is increasing. Papillary thyroid cancer and follicular thyroid cancer are the most common subtypes, comprising about 90% and 10% of cases, respectively. This paper provides c…
View article: Imaging recommendations in pediatric lymphoma: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Imaging recommendations in pediatric lymphoma: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper Open
Hodgkin lymphoma (HL) and non‐Hodgkin lymphoma (NHL) are both malignancies originating in the lymphatic system and both affect children, but many features differ considerably, impacting workup and management. This paper provides consensus‐…
View article: Imaging of Pediatric Thyroid Tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Imaging of Pediatric Thyroid Tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper Open
Pediatric thyroid cancer is rare in children, however incidence is increasing. Papillary thyroid cancer and follicular thyroid cancer are the most common subtypes, comprising about 90% and 10% of cases respectively. This manuscript provide…
View article: Diagnostic Accuracy of<sup>99m</sup>Tc-Sestamibi SPECT/CT for Characterization of Solid Renal Masses
Diagnostic Accuracy of<sup>99m</sup>Tc-Sestamibi SPECT/CT for Characterization of Solid Renal Masses Open
Our objective was to assess the diagnostic accuracy of 99mTc-sestamibi SPECT/CT for characterizing solid renal masses. Methods: Imaging and clinical records of patients who underwent 99mTc-sestamibi SPECT/CT for clinical work-up of their s…
View article: Metabolic Biomarkers Assessed with PET/CT Predict Sex-Specific Longitudinal Outcomes in Patients with Diffuse Large B-Cell Lymphoma
Metabolic Biomarkers Assessed with PET/CT Predict Sex-Specific Longitudinal Outcomes in Patients with Diffuse Large B-Cell Lymphoma Open
In many cancers, including lymphoma, males have higher incidence and mortality than females. Emerging evidence demonstrates that one mechanism underlying this phenomenon is sex differences in metabolism, both with respect to tumor nutrient…
View article: Phase II Study of Selumetinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Genetic Alterations: Arm E of the NCI-COG Pediatric MATCH Trial
Phase II Study of Selumetinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Genetic Alterations: Arm E of the NCI-COG Pediatric MATCH Trial Open
PURPOSE The NCI-COG Pediatric MATCH trial assigns patients age 1-21 years with relapsed or refractory solid tumors, lymphomas, and histiocytic disorders to phase II studies of molecularly targeted therapies on the basis of detection of pre…
View article: No-gold-standard evaluation of quantitative imaging methods in the presence of correlated noise
No-gold-standard evaluation of quantitative imaging methods in the presence of correlated noise Open
Objective evaluation of quantitative imaging (QI) methods with patient data is highly desirable, but is hindered by the lack or unreliability of an available gold standard. To address this issue, techniques that can evaluate QI methods wit…
View article: <scp>MR‐assisted PET</scp> respiratory motion correction using <scp>deep‐learning</scp> based <scp>short‐scan</scp> motion fields
<span>MR‐assisted PET</span> respiratory motion correction using <span>deep‐learning</span> based <span>short‐scan</span> motion fields Open
Purpose We evaluated the impact of PET respiratory motion correction (MoCo) in a phantom and patients. Moreover, we proposed and examined a PET MoCo approach using motion vector fields (MVFs) from a deep‐learning reconstructed short MRI sc…
View article: No-gold-standard evaluation of quantitative imaging methods in the presence of correlated noise
No-gold-standard evaluation of quantitative imaging methods in the presence of correlated noise Open
Objective evaluation of quantitative imaging (QI) methods with patient data is highly desirable, but is hindered by the lack or unreliability of an available gold standard. To address this issue, techniques that can evaluate QI methods wit…
View article: <sup>18</sup>F‐FDG positron emission tomography–computed tomography has a low positive predictive value for detecting occult recurrence in asymptomatic patients with high‐risk Stages IIB, IIC, and IIIA melanoma
<sup>18</sup>F‐FDG positron emission tomography–computed tomography has a low positive predictive value for detecting occult recurrence in asymptomatic patients with high‐risk Stages IIB, IIC, and IIIA melanoma Open
Background and Objectives High recurrence rates of Stages II and IIIA melanoma make close follow‐up essential, especially with new adjuvant therapies for metastatic disease. However, there are currently no consensus guidelines for routine …
View article: <sup>18</sup>F-FDG PET in Myocardial Viability Assessment: A Practical and Time-Efficient Protocol
<sup>18</sup>F-FDG PET in Myocardial Viability Assessment: A Practical and Time-Efficient Protocol Open
We assessed image quality using a practical and time-efficient protocol for intravenous glucose loading and insulin injection before administration of 18F-FDG for PET myocardial viability evaluation in patients with ischemic cardiomyopathy…
View article: A Bayesian approach to tissue-fraction estimation for oncological PET segmentation
A Bayesian approach to tissue-fraction estimation for oncological PET segmentation Open
Tumor segmentation in oncological PET is challenging, a major reason being the partial-volume effects (PVEs) that arise due to low system resolution and finite voxel size. The latter results in tissue-fraction effects (TFEs), i.e. voxels c…
View article: 00006 Yield of routine PET/CT surveillance imaging after primary surgical treatment for asymptomatic patients with high-risk stage II/III melanoma
00006 Yield of routine PET/CT surveillance imaging after primary surgical treatment for asymptomatic patients with high-risk stage II/III melanoma Open
IMPACT: The results of this research may influence NCCN guidelines on PET/CT surveillance for this population of patients for whom the guidelines are currently vague. OBJECTIVES/GOALS: We aim to quantify and describe the yield of surveilla…
View article: Observer study-based evaluation of a stochastic and physics-based method to generate oncological PET images
Observer study-based evaluation of a stochastic and physics-based method to generate oncological PET images Open
Objective evaluation of new and improved methods for PET imaging requires access to images with ground truth, as can be obtained through simulation studies. However, for these studies to be clinically relevant, it is important that the sim…
View article: A no-gold-standard technique to objectively evaluate quantitative imaging methods using patient data: Theory
A no-gold-standard technique to objectively evaluate quantitative imaging methods using patient data: Theory Open
Objective evaluation of quantitative imaging (QI) methods using measurements directly obtained from patient images is highly desirable but hindered by the non-availability of gold standards. To address this issue, statistical techniques ha…
View article: An estimation-based method to segment PET images.
An estimation-based method to segment PET images. Open
Tumor segmentation in oncological PET images is challenging, a major reason being the partial-volume effects that arise from low system resolution and a finite pixel size. The latter results in pixels containing more than one region, also …
View article: An estimation-based approach to tumor segmentation in oncological PET
An estimation-based approach to tumor segmentation in oncological PET Open
Tumor segmentation in oncological PET is challenging, a major reason being the partial-volume effects due to the low system resolution and finite voxel size. The latter results in tissue-fraction effects, i.e. voxels contain a mixture of t…
View article: Imaging of Pheochromocytoma and Paraganglioma
Imaging of Pheochromocytoma and Paraganglioma Open
With improvements in genetics and oncology, and increased cross-sectional imaging, there is rapid expansion in the existing knowledge regarding diagnosis and management of pheochromocytomas and paragangliomas (PPGL). According to the 2017 …
View article: Magnetic resonance enterography features of small bowel Crohn’s disease activity: an inter-rater reliability study of small bowel active inflammation in clinical practice setting
Magnetic resonance enterography features of small bowel Crohn’s disease activity: an inter-rater reliability study of small bowel active inflammation in clinical practice setting Open
Objective: The aim of this study is to determine the interrater agreement in a clinical practice environment for the most commonly used magnetic resonance enterography (MRE) features of Crohn’s disease (CD). Methods: CD patients with MRE’s…