Józef R. Lewandowski
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View article: Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase
Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase Open
Iterative polyketide synthases (iPKSs) rely on communication between acyl carrier protein (ACP) and acyltransferase (AT) domains to ensure efficient delivery of starter and extender substrates during biosynthesis. However, the molecular de…
View article: Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in <i>trans</i>-Acyltransferase Polyketide Synthases
Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in <i>trans</i>-Acyltransferase Polyketide Synthases Open
Polyketide synthases (PKSs) are multidomain enzymatic assembly lines that biosynthesize a wide selection of bioactive natural products from simple building blocks. In contrast to their cis-acyltransferase (AT) counterparts, trans…
View article: Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers
Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers Open
The complex multistep activation cascade of Ire1 involves changes in the Ire1 conformation and oligomeric state. Ire1 activation enhances ER folding capacity, in part by overexpressing the ER Hsp70 molecular chaperone BiP; in turn, BiP pro…
View article: Molecular chaperone BiP controls activity of the ER stress sensor Ire1 through interactions with its oligomers
Molecular chaperone BiP controls activity of the ER stress sensor Ire1 through interactions with its oligomers Open
The complex multistep activation cascade of Ire1 involves changes in the Ire1 conformation and oligomeric state. Ire1 activation enhances ER folding capacity, in part by overexpressing the ER Hsp70 molecular chaperone BiP; in turn, BiP pro…
View article: Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in<i>trans</i>-acyltransferase polyketide synthases
Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in<i>trans</i>-acyltransferase polyketide synthases Open
Polyketide synthases (PKSs) are multi-domain enzymatic assembly lines that biosynthesise a wide selection of bioactive natural products from simple building blocks. In contrast to their cis -acyltransferase (AT) counterparts, trans -AT PKS…
View article: Nuclear spin diffusion under fast magic-angle spinning in solid-state NMR
Nuclear spin diffusion under fast magic-angle spinning in solid-state NMR Open
Solid-state nuclear spin diffusion is the coherent and reversible process through which spin order is transferred via dipolar couplings. With the recent increases in magic-angle spinning (MAS) frequencies and magnetic fields becoming routi…
View article: CoMPaDReS: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants
CoMPaDReS: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants Open
Supporting dataset for paper
View article: CoMPaDReS: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants
CoMPaDReS: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants Open
Supporting dataset for paper
View article: Spin Diffusion under Fast Magic-Angle Spinning in Solid-State NMR
Spin Diffusion under Fast Magic-Angle Spinning in Solid-State NMR Open
Supporting data, scripts, and source code to go with the paper manuscript.
View article: Spin Diffusion under Fast Magic-Angle Spinning in Solid-State NMR
Spin Diffusion under Fast Magic-Angle Spinning in Solid-State NMR Open
Supporting data, scripts, and source code to go with the paper manuscript.
View article: CoMPaDReS: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants
CoMPaDReS: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants Open
Supporting data, scripts, and source code to go with the paper manuscript.
View article: CoMPaDReS: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants
CoMPaDReS: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants Open
Supporting data, scripts, and source code to go with the paper manuscript.
View article: Molecular dynamics simulations PksD AH
Molecular dynamics simulations PksD AH Open
This data set includes topology files, trajectories and force field parameters for non-standard residues for the molecular dynamics simulations discussed in the accompanying manuscript "Basis for controlled acyl chain hydrolysis in…
View article: Molecular dynamics simulations PksD AH
Molecular dynamics simulations PksD AH Open
This data set includes topology files, trajectories and force field parameters for non-standard residues for the molecular dynamics simulations discussed in an accompanying manuscript "Basis for controlled acyl chain hydrolysis in …
View article: Molecular dynamics simulations PksD AH
Molecular dynamics simulations PksD AH Open
This data set includes topology files, trajectories and force field parameters for non-standard residues for the molecular dynamics simulations discussed in the accompanying manuscript "Basis for controlled acyl chain hydrolysis in…
View article: Molecular dynamics simulations PksD AH
Molecular dynamics simulations PksD AH Open
This data set includes topology files, trajectories and force field parameters for non-standard residues for the molecular dynamics simulations discussed in the accompanying manuscript "Basis for controlled acyl chain hydrolysis in…
View article: Spin Diffusion under Fast Magic-Angle Spinning in Solid-State NMR
Spin Diffusion under Fast Magic-Angle Spinning in Solid-State NMR Open
Supporting data, scripts, and source code to go with the paper manuscript.
View article: Editorial: Biomolecular solid-state NMR: Methods and applications
Editorial: Biomolecular solid-state NMR: Methods and applications Open
EDITORIAL article Front. Mol. Biosci., 08 December 2022Sec. Structural Biology Volume 9 - 2022 | https://doi.org/10.3389/fmolb.2022.1082067
View article: Slice & Dice: nested spin–lattice relaxation measurements
Slice & Dice: nested spin–lattice relaxation measurements Open
Slice & Dice experiment accelerates up to 2.5 times measurements of spin–lattice relaxation rates for characterizing protein dynamics by nesting 13 C and 15 N experiments.
View article: MALPRACTICE: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants Dataset
MALPRACTICE: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants Dataset Open
Supporting data, scripts, and source code to go with the paper manuscript.
View article: MALPRACTICE: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants Dataset
MALPRACTICE: Quantification of Protein Dynamics by Solid-State NMR in the Presence of Paramagnetic Dopants Dataset Open
Supporting data, scripts, and source code to go with the paper manuscript.
View article: Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments
Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments Open
This is a supporting dataset for the manuscript "Slice and Dice: Nested Spin-lattice Relaxation Measurements" by W. Trent Franks, Jacqueline Tognetti and Józef R. Lewandowski. NMR_data.zip : Raw NMR data in the Bruker form…
View article: Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments
Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments Open
This is a supporting dataset for the manuscript "Slice and Dice: Nested Spin-lattice Relaxation Measurements" by W. Trent Franks, Jacqueline Tognetti and Józef R. Lewandowski. NMR_data.zip : Raw NMR data in the Bruker form…
View article: Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments
Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments Open
This is a supporting dataset for the manuscript "Slice and Dice: Nested Spin-lattice Relaxation Measurements" by W. Trent Franks, Jacqueline Tognetti and Józef R. Lewandowski. NMR_data.zip : Raw NMR data in the Bruker form…
View article: Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments
Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments Open
This is a supporting dataset for the manuscript "Slice and Dice: Nested Spin-lattice Relaxation Measurements" by W. Trent Franks, Jacqueline Tognetti and Józef R. Lewandowski. NMR_data.zip : Raw NMR data in the Bruker form…
View article: Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments
Supporting data for manuscript describing Slice and Dice method to measure NMR relaxation with nested experiments Open
This is a supporting dataset for the manuscript "Slice and Dice: Nested Spin-lattice Relaxation Measurements" by W. Trent Franks, Jacqueline Tognetti and Józef R. Lewandowski. NMR_data.zip : Raw NMR data in the Bruker form…
View article: Correction: Optimisation of <sup>1</sup>H PMLG homonuclear decoupling at 60 kHz MAS to enable <sup>15</sup>N–<sup>1</sup>H through-bond heteronuclear correlation solid-state NMR spectroscopy
Correction: Optimisation of <sup>1</sup>H PMLG homonuclear decoupling at 60 kHz MAS to enable <sup>15</sup>N–<sup>1</sup>H through-bond heteronuclear correlation solid-state NMR spectroscopy Open
Correction for ‘Optimisation of 1 H PMLG homonuclear decoupling at 60 kHz MAS to enable 15 N– 1 H through-bond heteronuclear correlation solid-state NMR spectroscopy’ by Jacqueline Tognetti et al. , Phys. Chem. Chem. Phys. , 2022, 24 , 202…
View article: Optimisation of <sup>1</sup>H PMLG homonuclear decoupling at 60 kHz MAS to enable <sup>15</sup>N–<sup>1</sup>H through-bond heteronuclear correlation solid-state NMR spectroscopy
Optimisation of <sup>1</sup>H PMLG homonuclear decoupling at 60 kHz MAS to enable <sup>15</sup>N–<sup>1</sup>H through-bond heteronuclear correlation solid-state NMR spectroscopy Open
15 N– 1 H heteronuclear NMR correlation at natural abundance in the solid state via J couplings is enabled by optimisation of phase-modulated Lee–Goldburg (PMLG) 1 H homonuclear decoupling during the spin echoes, far from the ideal magic-a…
View article: Dipolar Order Parameters in Large Systems With Fast Spinning
Dipolar Order Parameters in Large Systems With Fast Spinning Open
Order parameters are a useful tool for quantifying amplitudes of molecular motions. Here we measure dipolar order parameters by recoupling heteronuclear dipole-dipole couplings under fast spinning. We apply symmetry based recoupling method…
View article: Accelerating 15N and 13C R1 and R1ρ relaxation measurements by multiple pathway solid-state NMR experiments
Accelerating 15N and 13C R1 and R1ρ relaxation measurements by multiple pathway solid-state NMR experiments Open
Magic angle spinning (MAS) Solid-state NMR is a powerful technique to probe dynamics of biological systems at atomic resolution. R1 and R1ρ relaxation measurements can provide detailed insight on amplitudes and time s…