Jozeph L. Pendleton
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View article: A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function
A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function Open
Cardiac arrhythmias afflict tens of millions of people, causing one-fifth of all deaths 1 . Although mouse models have aided understanding of some pacemaker genes and arrhythmias 2,3 , mice are not known to naturally acquire arrhythmias, a…
View article: An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome
An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome Open
Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, hormone signaling by its very nature con…
View article: Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism
Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism Open
Mouse lemurs are the smallest, fastest reproducing, and among the most abundant primates, and an emerging model organism for primate biology, behavior, health and conservation. Although much has been learned about their physiology and thei…
View article: Fibrous Osteodystrophy, Chronic Renal Disease, and Uterine Adenocarcinoma in Aged Gray Mouse Lemurs (<i>Microcebus murinus</i>)
Fibrous Osteodystrophy, Chronic Renal Disease, and Uterine Adenocarcinoma in Aged Gray Mouse Lemurs (<i>Microcebus murinus</i>) Open
The gray mouse lemur ( Microcebus murinus , GML) is a nocturnal, arboreal, prosimian primate that is native to Madagascar. Captive breeding colonies of GMLs have been established primarily for noninvasive studies on questions related to ci…
View article: The Mouse Lemur, a Genetic Model Organism for Primate Biology, Behavior, and Health
The Mouse Lemur, a Genetic Model Organism for Primate Biology, Behavior, and Health Open
Systematic genetic studies of a handful of diverse organisms over the past 50 years have transformed our understanding of biology. However, many aspects of primate biology, behavior, and disease are absent or poorly modeled in any of the c…