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View article: Secondary Resections and Survival After Breast-Conserving Surgery in Breast Cancer Patients: A Cancer Registry-Based Cohort Study
Secondary Resections and Survival After Breast-Conserving Surgery in Breast Cancer Patients: A Cancer Registry-Based Cohort Study Open
Breast cancer remains the most common malignancy in women, and breast-conserving surgery (BCS) with adjuvant radiotherapy is a standard treatment for early-stage disease. This study assessed the impact of positive surgical margins and seco…
View article: Adhesion Prevention in Gynecologic Surgery: Guidance and Clinical Experience
Adhesion Prevention in Gynecologic Surgery: Guidance and Clinical Experience Open
Postoperative adhesions represent a major medical challenge and are associated with serious health and economic consequences. 4DryField® PH (PlantTec Medical GmbH, Lueneburg, Germany) is a starch-based medical device designed both to preve…
View article: Prognostic Impact of HER2 Low Status in Male Breast Cancer: Prospective Cohort Analysis
Prognostic Impact of HER2 Low Status in Male Breast Cancer: Prospective Cohort Analysis Open
Background: Male breast cancer (MBC) is a rare disease, and the potential influence of low expression of human epidermal growth factor receptor 2 (HER2 low) remains unexplored. Methods: In this prospective cohort study, we evaluated 870 pa…
View article: Prevention of peritoneal adhesions after gynecological surgery: a systematic review
Prevention of peritoneal adhesions after gynecological surgery: a systematic review Open
Importance The formation of adhesions after gynecological surgery not only has detrimental impacts on those affected, including pain, obstruction, and infertility, but also imposes a high economic burden on healthcare systems worldwide. Ob…
View article: Oncologic Outcome of Robotic-Assisted and Laparoscopic Sentinel Node Biopsy in Endometrial Cancer
Oncologic Outcome of Robotic-Assisted and Laparoscopic Sentinel Node Biopsy in Endometrial Cancer Open
Background: Recently, sentinel lymph node biopsy (SLNB) has been introduced in the surgical staging of endometrial cancer as an alternative to systematic lymph node dissection (LND). However, the survival impact of SLNB is not yet well cha…
View article: The representational geometry of emotional states in basolateral amygdala
The representational geometry of emotional states in basolateral amygdala Open
Sensory stimuli associated with aversive outcomes cause multiple behavioral responses related to an animal’s evolving emotional state, but neural mechanisms underlying these processes remain unclear. Here aversive stimuli were presented to…
View article: Methods for automating the analysis of live-cell single-molecule FRET data
Methods for automating the analysis of live-cell single-molecule FRET data Open
Single-molecule FRET (smFRET) is a powerful imaging platform capable of revealing dynamic changes in the conformation and proximity of biological molecules. The expansion of smFRET imaging into living cells creates both numerous new resear…
View article: Contralateral lymph node metastases in patients with vulvar cancer and unilateral sentinel lymph node metastases
Contralateral lymph node metastases in patients with vulvar cancer and unilateral sentinel lymph node metastases Open
Introduction The risk of contralateral lymph node metastases following unilateral sentinel lymph node (SLN) metastases in patients with vulvar cancer(s) remains to be systematically assessed. Material and methods We performed a multicenter…
View article: Single-molecule FRET imaging of GPCR dimers in living cells
Single-molecule FRET imaging of GPCR dimers in living cells Open
View article: Chronic Pain Releases Parabrachial Activity from Central Amygdala Inhibition
Chronic Pain Releases Parabrachial Activity from Central Amygdala Inhibition Open
Chronic pain is a complex neurologic condition that involves both sensory and affective components. A crucial integrator of pain-related sensation and affect may be a set of neurons within the parabrachial nucleus. This area receives nocic…
View article: Localized semi-nonnegative matrix factorization (LocaNMF) of widefield calcium imaging data
Localized semi-nonnegative matrix factorization (LocaNMF) of widefield calcium imaging data Open
Widefield calcium imaging enables recording of large-scale neural activity across the mouse dorsal cortex. In order to examine the relationship of these neural signals to the resulting behavior, it is critical to demix the recordings into …
View article: Detecting G Protein-coupled Receptor Complexes in Postmortem Human Brain with Proximity Ligation Assay and a Bayesian Classifier
Detecting G Protein-coupled Receptor Complexes in Postmortem Human Brain with Proximity Ligation Assay and a Bayesian Classifier Open
Despite the controversy regarding the existence and physiological relevance of class A G protein-coupled receptor dimerization, there is substantial evidence for functional interactions between the dopamine D2 receptor (D2R) and the adenos…
View article: Localized semi-nonnegative matrix factorization (LocaNMF) of widefield calcium imaging data
Localized semi-nonnegative matrix factorization (LocaNMF) of widefield calcium imaging data Open
Widefield calcium imaging enables recording of large-scale neural activity across the mouse dorsal cortex. In order to examine the relationship of these neural signals to the resulting behavior, it is critical to demix the recordings into …
View article: A Magyar Államkincstár szerepvállalása az önkormányzati alrendszer szabályos működésének elősegítésében The Hungarian State Treasury’s role in promoting the proper functioning of the local government subsystem
A Magyar Államkincstár szerepvállalása az önkormányzati alrendszer szabályos működésének elősegítésében The Hungarian State Treasury’s role in promoting the proper functioning of the local government subsystem Open
A Magyar Államkincstár szerepvállalása az önkormányzati alrendszer szabályos működésének
\nelősegítésében című cikk az önkormányzati alrendszer szabályos működését elősegítő állami tevékenységeket veszi górcső alá, melyek közül kiemelten f…
View article: Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus
Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus Open
Dopamine neurotransmission is suspected to play important physiological roles in multiple sparsely innervated brain nuclei, but there has not been a means to measure synaptic dopamine release in such regions. The globus pallidus externa (G…
View article: Author response: Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus
Author response: Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Dopamine neurotransmission is suspected to…
View article: Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum Open
View article: Optical characterization of dopamine release in the globus pallidus and striatum
Optical characterization of dopamine release in the globus pallidus and striatum Open
The measurement of dopamine neurotransmission in the brain has evolved alongside techniques for measuring neuronal activity. This evolution has progressed from coarse physical inspection (using lesions or dialysis approaches) to measuring …
View article: Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action
Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action Open
Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in mice with upregulated…
View article: Evidence against dopamine D1/D2 receptor heteromers
Evidence against dopamine D1/D2 receptor heteromers Open