Jianping Xu
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View article: Design of Artificial Peptide Against HIV-1 Based on the Heptad-Repeat Rules and Membrane-Anchor Strategies
Design of Artificial Peptide Against HIV-1 Based on the Heptad-Repeat Rules and Membrane-Anchor Strategies Open
Objective: The six-helix bundle (6-HB) is critical for HIV-1 membrane fusion. To disrupt this process, peptide inhibitors have been meticulously designed to target interactions within the 6-HB regions, thereby blocking membrane fusion and …
View article: Genomic evidence for a-α heterothallic and α-α unisexual mating and recombination in an environmental Cryptococcus deneoformans population
Genomic evidence for a-α heterothallic and α-α unisexual mating and recombination in an environmental Cryptococcus deneoformans population Open
Cryptococcus deneoformans is a human fungal pathogen capable of both a-α and α-α mating and sexual reproduction in laboratory settings. However, the extent of a-α and α-α sexual reproductions in natural populations remain unexplored. Here …
View article: Research advances and public health strategies in China on WHO priority fungal pathogens
Research advances and public health strategies in China on WHO priority fungal pathogens Open
Fungal pathogens pose significant and increasing threats to public health. Each year, over a billion people are infected by fungal pathogens, directly contributing to millions of deaths. To overcome the challenge of fungal threat, in 2022,…
View article: Analysis of FsTyDC1 Gene from Forsythia suspensa in Response to Drought and Salt Stress Treatment
Analysis of FsTyDC1 Gene from Forsythia suspensa in Response to Drought and Salt Stress Treatment Open
Background: Forsythia suspensa (Thunb.) Vahl is a perennial deciduous shrub of the Oleaceae family. Its dried mature fruits are used as medicine and hold an important position in traditional Chinese medicine. Tyrosine decarboxylase (TyDC) …
View article: The Study of Social Interaction and Sense of Place in Private Art Museums of Eastern China from the Perspective of Cultural Sustainability
The Study of Social Interaction and Sense of Place in Private Art Museums of Eastern China from the Perspective of Cultural Sustainability Open
This study investigates the social processes of place-making, sense of place, and place branding within the context of private art museums in Eastern China, highlighting their role in fostering social interaction and contributing to urban …
View article: Molecular epidemiology and antibiotic resistance of group B Streptococcus in pregnant women and neonates from Haikou, China: implications for vaccine development and antimicrobial stewardship
Molecular epidemiology and antibiotic resistance of group B Streptococcus in pregnant women and neonates from Haikou, China: implications for vaccine development and antimicrobial stewardship Open
Group B Streptococcus (GBS) is a major cause of pregnancy complication and neonatal morbidity and mortality worldwide, particularly in developing regions. Despite its clinical importance, data on the molecular epidemiology, antibiotic resi…
View article: Ore Genesis of the Jiawula Pb–Zn–Ag Deposit, Inner Mongolia: Constraints from C–H–O Isotopes, In Situ S Isotopes, Fluid Inclusions, and LA-ICP-MS Analysis of Chalcopyrite
Ore Genesis of the Jiawula Pb–Zn–Ag Deposit, Inner Mongolia: Constraints from C–H–O Isotopes, In Situ S Isotopes, Fluid Inclusions, and LA-ICP-MS Analysis of Chalcopyrite Open
The Jiawula large-scale Pb-Zn-Ag deposit occurs within Jurassic volcanic rocks, structurally controlled by NW-trending faults. This study integrates systematic analyses of chalcopyrite trace elements, fluid inclusions, and stable isotopes …
View article: Genome-wide identification and expression profiles of the superoxide dismutase (SOD) genes in Lentinula edodes
Genome-wide identification and expression profiles of the superoxide dismutase (SOD) genes in Lentinula edodes Open
The superoxide dismutase (SOD) enzymes are a group of key enzymes involved in oxidative stress defense and play a significant role in organismal growth and development. The SOD gene family has been identified in many plants, animals, and s…
View article: Genomic Evidence for a-α Heterothallic and α-α Unisexual Mating and Recombination in an Environmental Cryptococcus deneoformans Population
Genomic Evidence for a-α Heterothallic and α-α Unisexual Mating and Recombination in an Environmental Cryptococcus deneoformans Population Open
Cryptococcus deneoformans is a human fungal pathogen capable of both a-α and α-α mating and sexual reproduction in laboratory settings. However, the extent of a-α and α-α sexual reproductions in natural populations remain unexplored. Here …
View article: Functional differentiation of industrial hemp rhizosphere microbiome along environmental gradients
Functional differentiation of industrial hemp rhizosphere microbiome along environmental gradients Open
The southwestern, central, and northeastern regions of China are the primary cultivation areas for industrial hemp. Microorganisms within the soil-root continuum play a crucial role in plant health. However, the mechanisms by which these m…
View article: Investigation of the Main Factors Influencing Gen Z Users' Willingness to Subscribe/Renew Music Streaming Platforms
Investigation of the Main Factors Influencing Gen Z Users' Willingness to Subscribe/Renew Music Streaming Platforms Open
The global music industry is increasingly dominated by streaming services, which now account for 84% of recorded music revenue. For Gen Z, music streaming is a primary mode of consumption, making it vital to understand what drives their su…
View article: Genesis of the Erentaolegai Silver Deposit, Inner Mongolia, Northeast China: Evidence from Fluid Inclusion and H-O-S Isotopes
Genesis of the Erentaolegai Silver Deposit, Inner Mongolia, Northeast China: Evidence from Fluid Inclusion and H-O-S Isotopes Open
The Erentaolegai silver deposit is located within the Derbugan metallogenic belt in the eastern segment of the Central Asia–Mongolia giant orogenic belt. The ore bodies are primarily hosted in the volcanic rocks of the Middle Jurassic Tamu…
View article: Fatal cryptococcal meningitis in an immunocompetent patient
Fatal cryptococcal meningitis in an immunocompetent patient Open
Introduction: Cryptococcal meningitis (CM) typically affects immunocompromised individuals and are commonly caused by Cryptococcus neoformans. Case Report: We present CM case involving an immunocompetent male due to Cryptococcus gattii mol…
View article: Species diversity of Cladosporium in Citrus and the genetic mechanisms for C. cladosporioides complex to adapt broad host plants
Species diversity of Cladosporium in Citrus and the genetic mechanisms for C. cladosporioides complex to adapt broad host plants Open
Cladosporium represents one of the most common fungal groups on plants and has been reported as a core microbiome of several plants. Some species are important for agriculture because they are pathogens causing diseases in some economicall…
View article: Inbreeding and Genetic Differentiation Among Geographic Populations of Lactarius hatsudake in Southwest China
Inbreeding and Genetic Differentiation Among Geographic Populations of Lactarius hatsudake in Southwest China Open
Lactarius hatsudake is an economically important wild edible fungus in sub-tropical and temperate Asia. At present, little is known about its genetic diversity, mode of reproduction, and population structure in natural environments. In thi…
View article: Genomic characterization of Candida parapsilosis hospital isolates revealed the spread and persistence of a fluconazole-resistant cluster associated with increased erg11 copies
Genomic characterization of Candida parapsilosis hospital isolates revealed the spread and persistence of a fluconazole-resistant cluster associated with increased erg11 copies Open
Candida parapsilosis is one of the most common species associated with candidemia infections globally. Recently, the emergence of fluconazole-resistant C. parapsilosis has become a significant global public health concern. In this study, w…
View article: Splitting the difference: Genetically-tunable mycelial films using natural genetic variations in schizophyllum commune
Splitting the difference: Genetically-tunable mycelial films using natural genetic variations in schizophyllum commune Open
Fungal mycelium, renowned for its robust fiber structure, is gaining widespread attention as a sustainable alternative to traditional plastics and textiles. Strain optimization offers the opportunity to improve these mycelial materials by …
View article: DNA metabarcode analyses reveal similarities and differences in plant microbiomes of industrial hemp and medicinal Cannabis in China
DNA metabarcode analyses reveal similarities and differences in plant microbiomes of industrial hemp and medicinal Cannabis in China Open
Endophytic bacteria within plant tissues play crucial roles in plant health, stress tolerance, and contribute to the metabolite diversity of host plants. Cannabis sativa L. is an economically significant plant, with industrial hemp (IH) an…
View article: High Diversity and Low Genetic Differentiation Among Geographic Populations of Myotis yumanensis in Western Canada
High Diversity and Low Genetic Differentiation Among Geographic Populations of Myotis yumanensis in Western Canada Open
Myotis yumanensis is a small insectivorous bat distributed in Western North America and is susceptible to white-nose syndrome, a devastating fungal disease. Effective management of the disease in M. yumanensis requires an understanding of …
View article: Prevalence, drug resistance and genetic diversity of <i>Candida glabrata</i> in the reproductive tract of pregnant women in Hainan and comparison with global multilocus sequence data
Prevalence, drug resistance and genetic diversity of <i>Candida glabrata</i> in the reproductive tract of pregnant women in Hainan and comparison with global multilocus sequence data Open
This study investigates the prevalence, drug resistance, and genetic diversity of Candida glabrata, a significant non-albicans Candida species, among pregnant women in Hainan, China. We collected 3,806 reproductive tract secretion samples …
View article: Genomic analyses reveal high diversity and rapid evolution of <i>Pichia kudriavzevii</i> within a neonatal intensive care unit in Delhi, India
Genomic analyses reveal high diversity and rapid evolution of <i>Pichia kudriavzevii</i> within a neonatal intensive care unit in Delhi, India Open
Pichia kudriavzevii causes life-threatening infections in immunocompromised hosts, including hospitalized neonates. This pathogen is intrinsically resistant to fluconazole, while uncommon P. kudriavzevii strains resistant to multiple antif…
View article: Structures and determinants of soil microbiomes along a steep elevation gradient in Southwest China
Structures and determinants of soil microbiomes along a steep elevation gradient in Southwest China Open
Soil microbial communities play a vital role in accelerating nutrient cycling and stabilizing ecosystem functions in forests. However, the diversity of soil microbiome and the mechanisms driving their distribution patterns along elevationa…
View article: Co‐Infection of Pulmonary Aspergillosis and Cryptococcal Meningitis in an HIV‐Positive Patient: A Case Report
Co‐Infection of Pulmonary Aspergillosis and Cryptococcal Meningitis in an HIV‐Positive Patient: A Case Report Open
Opportunistic fungal infections (OFIs) are common among human immunodeficiency virus (HIV) –positive patients, especially in those with delayed diagnosis and treatment. Patients with severe HIV/AIDS with clusters of differentiation 4 (CD4)…
View article: Geologic hydrogen: a review of resource potential, subsurface dynamics, exploration, production, transportation, and research opportunities
Geologic hydrogen: a review of resource potential, subsurface dynamics, exploration, production, transportation, and research opportunities Open
This paper provides a comprehensive review of geologic hydrogen, covering its resource potential, origins, migration and trapping mechanisms, exploration techniques, production strategies, and pipeline transportation.
View article: Characterization of Endofungal Bacteria and Their Role in the Ectomycorrhizal Fungus Helvella bachu
Characterization of Endofungal Bacteria and Their Role in the Ectomycorrhizal Fungus Helvella bachu Open
Helvella bachu, an ectomycorrhizal fungus, forms a symbiotic relationship with Populus euphratica, a rare and endangered species crucial to desert riparian ecosystems. In this study, endofungal bacteria (EFBs) within the fruiting bodies of…
View article: Genomic and Transcriptomic Analyses Revealed DdSTE2 Play a Role in Constricting Ring Formation in the Nematode-Trapping Fungi Drechslerella dactyloides
Genomic and Transcriptomic Analyses Revealed DdSTE2 Play a Role in Constricting Ring Formation in the Nematode-Trapping Fungi Drechslerella dactyloides Open
The carnivorous fungus Drechslerella dactyloides can form constricting rings through hyphal specialization to capture nematodes. The formation of constricting rings is a prerequisite for capturing nematodes and a characteristic of entering…