James R. Baker
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View article: Transepidermal water loss increases during murine food anaphylaxis and reflects reaction severity
Transepidermal water loss increases during murine food anaphylaxis and reflects reaction severity Open
Background An increase in transepidermal water loss (TEWL) presages food anaphylaxis in allergic humans during oral food challenges. We sought to determine whether similar TEWL changes occur in mouse food anaphylaxis models. Methods Using …
View article: Rational adjuvant selection for the neonatal period shapes unique and lasting immune polarization in mice
Rational adjuvant selection for the neonatal period shapes unique and lasting immune polarization in mice Open
A major knowledge gap exists in understanding immune effects of adjuvants in early life. As environmental stimuli shape the infant immune system, adjuvants may also influence this process. Using a neonatal mouse model, we investigated the …
View article: Bone health perspectives among Indigenous people: a qualitative study
Bone health perspectives among Indigenous people: a qualitative study Open
Objectives To explore perspectives and beliefs on bone health among Indigenous adults in Victoria. Design Qualitative focus groups with semi‐structured questions. Focus group discussions were analysed for themes and subthemes using an Indi…
View article: Enhanced mucosal SARS-CoV-2 immunity after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant
Enhanced mucosal SARS-CoV-2 immunity after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant Open
Current COVID-19 mRNA vaccines delivered intramuscularly (IM) induce effective systemic immunity, but with suboptimal immunity at mucosal sites, limiting their ability to impart sterilizing immunity. There is strong interest in rerouting i…
View article: Nanoemulsion is an effective antimicrobial for methicillin-resistant <i>Staphylococcus aureus</i> in infected swine skin burn wounds
Nanoemulsion is an effective antimicrobial for methicillin-resistant <i>Staphylococcus aureus</i> in infected swine skin burn wounds Open
Burns are one of the most common injuries in both civilian and combat settings and are difficult to treat. This is particularly true when the wounds are infected with antibiotic-resistant bacteria such as methicillin-resistant Staphylococc…
View article: Enhanced mucosal B- and T-cell responses against SARS-CoV-2 after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant
Enhanced mucosal B- and T-cell responses against SARS-CoV-2 after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant Open
Current COVID-19 mRNA vaccines delivered intramuscularly (IM) induce effective systemic immunity, but with suboptimal immunity at mucosal sites, limiting their ability to impart sterilizing immunity. There is strong interest in rerouting i…
View article: Recent patents in allergy and immunology: Transepidermal water loss for anaphylaxis monitoring
Recent patents in allergy and immunology: Transepidermal water loss for anaphylaxis monitoring Open
Peer Reviewed
View article: Delicate Hybrid Laponite–Cyclic Poly(ethylene glycol) Nanoparticles as a Potential Drug Delivery System
Delicate Hybrid Laponite–Cyclic Poly(ethylene glycol) Nanoparticles as a Potential Drug Delivery System Open
The objective of the study was to explore the feasibility of a new drug delivery system using laponite (LAP) and cyclic poly(ethylene glycol) (cPEG). Variously shaped and flexible hybrid nanocrystals were made by both the covalent and phys…
View article: Retinoic Acid Signaling Is Required for Dendritic Cell Maturation and the Induction of T Cell Immunity
Retinoic Acid Signaling Is Required for Dendritic Cell Maturation and the Induction of T Cell Immunity Open
Vitamin A and its biologically active metabolites, all-trans and 9-cis retinoic acid (RA), are thought to be important in generating and modulating immune function. However, RA modulates the function of many types of immune cells, and its …
View article: A rationally designed combined intranasal adjuvant drives robust and broad humoral, cellular, and mucosal immune responses to SARS-CoV-2
A rationally designed combined intranasal adjuvant drives robust and broad humoral, cellular, and mucosal immune responses to SARS-CoV-2 Open
Multiple FDA-approved SARS-CoV-2 vaccines have provided excellent protection against severe disease. Despite this, immunity can wane relatively fast, particularly in the elderly and novel viral variants capable of evading infection- and va…
View article: Effective Treatment of Skin Wounds Co-Infected with Multidrug-Resistant Bacteria with a Novel Nanoemulsion
Effective Treatment of Skin Wounds Co-Infected with Multidrug-Resistant Bacteria with a Novel Nanoemulsion Open
Infections, specifically polymicrobial, can cause serious consequences when it comes to wound treatment. Prolonged treatment with antibiotics can lead to an increased risk of bacterial resistance; co-infections can complicate treatment opt…
View article: Targeted Allergen-Specific Immunotherapy within the Skin Improves Allergen Delivery to Induce Desensitization to Peanut
Targeted Allergen-Specific Immunotherapy within the Skin Improves Allergen Delivery to Induce Desensitization to Peanut Open
Aim: Epicutaneous immunotherapy (EPIT) with peanut has been demonstrated to be safe but efficacy may be limited by allergen uptake through the skin barrier. To enhance allergen uptake into the skin, the authors used peanut-coated microneed…
View article: Safety of peanut (Arachis hypogaea) allergen powder-dnfp in children and teenagers with peanut allergy: Pooled summary of phase 3 and extension trials
Safety of peanut (Arachis hypogaea) allergen powder-dnfp in children and teenagers with peanut allergy: Pooled summary of phase 3 and extension trials Open
The safety profile of PTAH was consistent across trials, manageable, and improved over time. AEs were predominantly mild to moderate, and all grades declined in frequency with continued treatment. These data can be used to facilitate share…
View article: A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine
A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine Open
Several SARS-CoV-2 vaccines have received EUAs, but many issues remain unresolved, including duration of conferred immunity and breadth of cross-protection. Adjuvants that enhance and shape adaptive immune responses that confer broad prote…
View article: Mild SARS-CoV-2 Illness Is Not Associated with Reinfections and Provides Persistent Spike, Nucleocapsid, and Virus-Neutralizing Antibodies
Mild SARS-CoV-2 Illness Is Not Associated with Reinfections and Provides Persistent Spike, Nucleocapsid, and Virus-Neutralizing Antibodies Open
This article demonstrates that people who have mild COVID-19 illnesses and produce antibodies are protected from reinfection for up to 6 months afterward. The antibodies that people produce in this situation are stable for up to 6 months a…
View article: Dermal Nanoemulsion Treatment Reduces Burn Wound Conversion and Improves Skin Healing in a Porcine Model of Thermal Burn Injury
Dermal Nanoemulsion Treatment Reduces Burn Wound Conversion and Improves Skin Healing in a Porcine Model of Thermal Burn Injury Open
Burn wound progression is an inflammation-driven process where an initial partial-thickness thermal burn wound can evolve over time to a full-thickness injury. We have developed an oil-in-water nanoemulsion formulation (NB-201) containing …