Carl J. Lavie
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View article: Fit Is It and Muscling Up to Prevent Chronic Kidney Disease
Fit Is It and Muscling Up to Prevent Chronic Kidney Disease Open
View article: Late stent failure: Rethinking biomarkers through the lens of the neutrophil-to-high -density lipoprotein ratio
Late stent failure: Rethinking biomarkers through the lens of the neutrophil-to-high -density lipoprotein ratio Open
View article: Reply
Reply Open
View article: Worsening versus advanced heart failure: Management and challenges
Worsening versus advanced heart failure: Management and challenges Open
Heart failure (HF) is a progressive condition marked by recurrent episodes of symptom exacerbation, leading to worsening cardiac function, increased hospitalization and mortality risk. Worsening HF (WHF) and advanced HF (AdvHF) represent t…
View article: Multimorbidity and the Risk of Sudden Cardiac Death
Multimorbidity and the Risk of Sudden Cardiac Death Open
In middle-aged and older men, multimorbidity is strongly linked to an increased risk of SCD, independent of known cardiovascular risk factors. Furthermore, the risk of SCD rises progressively with the number of coexisting health conditions.
View article: U‐Shaped Relationship Between White Blood Cell Counts and Incident Hypertension in Military Young Adults: The CHIEF Study, 2014–2020
U‐Shaped Relationship Between White Blood Cell Counts and Incident Hypertension in Military Young Adults: The CHIEF Study, 2014–2020 Open
Background Systemic low‐grade inflammation, which is characterized by increased counts of blood leukocytes (white blood cells, WBCs), can lead to hypertension, while reduced WBC counts caused by the use of some substances, e.g., alcohol, c…
View article: Fit Is it for Longevity and Prevention of Multimorbidity
Fit Is it for Longevity and Prevention of Multimorbidity Open
View article: Association Between Trunk Fat Mass Index and Diabetes in a Multinational Population
Association Between Trunk Fat Mass Index and Diabetes in a Multinational Population Open
Within a specific BMI category, individuals with a high trunk fat mass are more likely to experience diabetes compared with those with lower levels of central fat.
View article: Toxic Grounds: A Narrative Review of the Role of Heavy Metal Soil and Water Contamination in Cardiovascular Disease Development
Toxic Grounds: A Narrative Review of the Role of Heavy Metal Soil and Water Contamination in Cardiovascular Disease Development Open
Cardiovascular disease (CVD) remains a leading cause of global mortality, with environmental exposures increasingly recognized as significant contributors alongside traditional risk factors. Among these, heavy metal contamination of soil a…
View article: Mental stress and the risks of metabolic syndrome and related components in military personnel: CHIEF cohort study
Mental stress and the risks of metabolic syndrome and related components in military personnel: CHIEF cohort study Open
Background The association observed between mental stress and metabolic syndrome (MetS) has varied across studies and may be confounded by physical activity (PA) and fitness status. Method This study included a military cohort of 2,854 par…
View article: Integrating omics to optimize precision cardiac rehabilitation
Integrating omics to optimize precision cardiac rehabilitation Open
Cardiovascular diseases (CVD) remain the leading global cause of mortality with a complex etiology involving both genetic and environmental factors. Despite the identification of numerous genetic loci associated with CVD, the mechanisms un…
View article: Broad adoption of healthy living education in medical school–the time has come
Broad adoption of healthy living education in medical school–the time has come Open
View article: Practical Implications of Obesity for Cardiovascular Diagnostics
Practical Implications of Obesity for Cardiovascular Diagnostics Open
Obesity, one of the most prevalent and pressing global health challenges, has significant implications for cardiovascular disease (CVD) morbidity and mortality. Diagnostic testing for CVD is substantially affected by obesity, which affects…
View article: SGLT2 inhibitors across various patient populations in the era of precision medicine: the multidisciplinary team approach
SGLT2 inhibitors across various patient populations in the era of precision medicine: the multidisciplinary team approach Open
View article: Bolstering Health Outcomes by Emerging from the Least Fit Population Cohort: The Impact of Exercise Training Intensities > 3 Metabolic Equivalents
Bolstering Health Outcomes by Emerging from the Least Fit Population Cohort: The Impact of Exercise Training Intensities > 3 Metabolic Equivalents Open
View article: Physical activity fragmentation—a new frontier in physical health?
Physical activity fragmentation—a new frontier in physical health? Open
View article: Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel
Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel Open
Background Left atrial (LA) size and function are linked to exercise intolerance in heart failure, while associations between LA parameters and exercise performance remain unclear in athletes. Objectives This study aimed to identify correl…
View article: Epicardial adipose tissue, cardiac damage, and mortality in patients undergoing TAVR for aortic stenosis
Epicardial adipose tissue, cardiac damage, and mortality in patients undergoing TAVR for aortic stenosis Open
Computed tomography (CT)-derived Epicardial Adipose Tissue (EAT) is linked to cardiovascular disease outcomes. However, its role in patients undergoing Transcatheter Aortic Valve Replacement (TAVR) and the interplay with aortic stenosis (A…
View article: Pharmaceutical and clinical implications of proton pump inhibitors with dual antiplatelet therapies: a systematic review
Pharmaceutical and clinical implications of proton pump inhibitors with dual antiplatelet therapies: a systematic review Open
View article: Lifestyle, Environment, and Cardiovascular Diseases
Lifestyle, Environment, and Cardiovascular Diseases Open
View article: Management of children with heterozygous familial hypercholesterolaemia worldwide: a meta-analysis
Management of children with heterozygous familial hypercholesterolaemia worldwide: a meta-analysis Open
Aims Heterozygous familial hypercholesterolaemia (HeFH) is one of the most frequent monogenic disorders in the world, leading to premature atherosclerotic cardiovascular diseases. The aim of this meta-analysis was to evaluate the efficacy …
View article: Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword
Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword Open
View article: Soft drinks, fish oil and atrial fibrillation
Soft drinks, fish oil and atrial fibrillation Open
View article: Reducing Rates of Exercise- and Sports-Related Cardiac Mortality
Reducing Rates of Exercise- and Sports-Related Cardiac Mortality Open
View article: Bolstering the Prognostic Utility of Coronary Risk Assessments with PAI: A Physical Activity Metric
Bolstering the Prognostic Utility of Coronary Risk Assessments with PAI: A Physical Activity Metric Open
Purpose Personal activity intelligence (PAI) translates heart rate during physical activity (PA) into a weekly score, which credits vigorous over low- and moderate-intensity PA. We prospectively investigated the association between PAI and…
View article: Management of Children with Heterozygous Familial Hypercholesterolemia Worldwide: A Meta-Analysis.
Management of Children with Heterozygous Familial Hypercholesterolemia Worldwide: A Meta-Analysis. Open
Heterozygous familial hypercholesterolemia (HeFH) is one of the most frequent monogenic disorders in the world, leading to premature atherosclerotic cardiovascular diseases (ASCVD). The aim of this meta-analysis was to evaluate the efficac…
View article: Healthy Lifestyle and Cardiac Rehabilitation for Weight Loss
Healthy Lifestyle and Cardiac Rehabilitation for Weight Loss Open
View article: Racial disparities in trend, clinical characteristics and outcomes in Takotsubo syndrome
Racial disparities in trend, clinical characteristics and outcomes in Takotsubo syndrome Open
Our study suggested significant differences in the outcomes of TTS across different racial groups. Hispanic populations experienced a higher mortality rate with TTS during the COVID-19 era. Further research should emphasize discovering the…
View article: Physical Activity, Cardiorespiratory Fitness, and the Obesity Paradox with Consideration for Racial and/or Ethnic Differences: A Broad Review and Call to Action
Physical Activity, Cardiorespiratory Fitness, and the Obesity Paradox with Consideration for Racial and/or Ethnic Differences: A Broad Review and Call to Action Open
Despite decades of extensive research and clinical insights on the increased risk of all-cause and disease-specific morbidity and mortality due to obesity, the obesity paradox still presents a unique perspective, i.e., having a higher body…
View article: Exploring the Molecular Adaptations, Benefits, and Future Direction of Exercise Training: Updated Insights into Cardiovascular Health
Exploring the Molecular Adaptations, Benefits, and Future Direction of Exercise Training: Updated Insights into Cardiovascular Health Open
This review emphasizes the globally accepted physical activity guidelines and explores the various molecular adaptations that occur with continuous exercise. It is essential to highlight the critical roles of cardiorespiratory fitness, mus…