Moon S. Chen
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View article: Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative
Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative Open
We present a large whole-body and total-body curated dataset of dual-modality 2-deoxy-2-[18F]fluoro-D-glucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) studies, consisting of 1,597 PET/CT images and the corresponding …
View article: Quantitative Total-Body Imaging of Blood Flow with High-Temporal-Resolution Early Dynamic<sup>18</sup>F-FDG PET Kinetic Modeling
Quantitative Total-Body Imaging of Blood Flow with High-Temporal-Resolution Early Dynamic<sup>18</sup>F-FDG PET Kinetic Modeling Open
Past efforts to measure blood flow with the widely available radiotracer 18F-FDG were limited to tissues with high 18F-FDG extraction fraction. In this study, we developed an early dynamic 18F-FDG PET metho…
View article: Quantitative PET imaging and modeling of molecular blood-brain barrier permeability
Quantitative PET imaging and modeling of molecular blood-brain barrier permeability Open
Neuroimaging of blood-brain barrier permeability has been instrumental in identifying its broad involvement in neurological and systemic diseases. However, current methods evaluate the blood-brain barrier mainly as a structural barrier. He…
View article: Elevated risk of lung cancer among Asian American women who have never smoked: an emerging cancer disparity
Elevated risk of lung cancer among Asian American women who have never smoked: an emerging cancer disparity Open
Lung cancer is a leading cause of cancer mortality for most ethnic groups of Asian American women, including Chinese, Korean, Japanese, and Vietnamese Americans, a striking pattern given the exceedingly low prevalence of smoking among Asia…
View article: Quantitative Total-Body Imaging of Blood Flow with High Temporal Resolution Early Dynamic<sup>18</sup>F-Fluorodeoxyglucose PET Kinetic Modeling
Quantitative Total-Body Imaging of Blood Flow with High Temporal Resolution Early Dynamic<sup>18</sup>F-Fluorodeoxyglucose PET Kinetic Modeling Open
Quantitative total-body PET imaging of blood flow can be performed with freely diffusible flow radiotracers such as 15 O-water and 11 C-butanol, but their short half-lives necessitate close access to a cyclotron. Past efforts to measure bl…
View article: Quantitative PET imaging and modeling of molecular blood-brain barrier permeability
Quantitative PET imaging and modeling of molecular blood-brain barrier permeability Open
Blood-brain barrier (BBB) disruption is involved in the pathogenesis and progression of many neurological and systemic diseases. Non-invasive assessment of BBB permeability in humans has mainly been performed with dynamic contrast-enhanced…
View article: Association Between COVID-19 and Planned and Postponed Cancer Screenings Among American Indian Adults Residing in California and Oklahoma, March–December 2020
Association Between COVID-19 and Planned and Postponed Cancer Screenings Among American Indian Adults Residing in California and Oklahoma, March–December 2020 Open
Objective: Little is known about how the COVID-19 pandemic affected cancer screenings among American Indian people residing in California and Oklahoma, 2 states with the largest American Indian populations. We assessed rates and factors as…
View article: “You Don’t Know If It’s the Truth or a Lie”: Exploring Human Papillomavirus (HPV) Vaccine Hesitancy among Communities with Low HPV Vaccine Uptake in Northern California
“You Don’t Know If It’s the Truth or a Lie”: Exploring Human Papillomavirus (HPV) Vaccine Hesitancy among Communities with Low HPV Vaccine Uptake in Northern California Open
Background: Vaccine hesitancy, delaying or refusing to vaccinate despite the availability of vaccines, impedes the progress of achieving optimal HPV vaccine coverage. Little is known about the sources of human papillomavirus (HPV) vaccine …
View article: Tobacco and marijuana use during the COVID-19 pandemic lockdown among American Indians residing in California and Oklahoma
Tobacco and marijuana use during the COVID-19 pandemic lockdown among American Indians residing in California and Oklahoma Open
We observed high rates of tobacco use during the COVID-19 pandemic, consistent with other studies. Research is needed to examine whether tobacco and marijuana use will decrease to pre-pandemic levels post-pandemic or if these behaviors wil…
View article: Avoidance of medical care among American Indians with a history of cancer during the coronavirus pandemic
Avoidance of medical care among American Indians with a history of cancer during the coronavirus pandemic Open
Objectives Assess the percentage of cancer-related appointment delays, cancelations, and the unavailability of medications experienced by American Indian participants during the COVID-19 pandemic. Methods This cross-sectional survey study …
View article: A pharmacist-led community-based survey study: Determining the impact of the Covid-19 pandemic on actionable factors associated with worse cancer outcomes and cancer health disparities
A pharmacist-led community-based survey study: Determining the impact of the Covid-19 pandemic on actionable factors associated with worse cancer outcomes and cancer health disparities Open
Our data can be used to help guide pharmacist-led targeted outreach in our community which will help mitigate Covid-19 pandemic-driven changes in behaviors associated with worse cancer outcomes and exacerbation of cancer health disparities…
View article: 18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner
18F-FDG gallbladder uptake: observation from a total-body PET/CT scanner Open
Background Total-body positron emission tomography/computed tomography (PET/CT) scanners are characterized by higher signal collection efficiency and greater spatial resolution compared to conventional scanners, allowing for delayed imagin…
View article: Automated electronic health <scp>registry‐based</scp> hepatitis B screening
Automated electronic health <span>registry‐based</span> hepatitis B screening Open
Gilead Sciences, Inc. (Eric Chak received a research grant). The other authors have no conflicts of interest to report. Eric Chak served as the guarantor of the article. The data that support the findings of this study are openly available…
View article: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis
A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis Open
Patient-derived xenografts (PDXs) model human intra-tumoral heterogeneity in the context of the intact tissue of immunocompromised mice. Histological imaging via hematoxylin and eosin (H&E) staining is performed on PDX samples for routine …
View article: A Cancer Health Needs Assessment Reveals Important Differences Between US-Born and Foreign-Born Latinos in California
A Cancer Health Needs Assessment Reveals Important Differences Between US-Born and Foreign-Born Latinos in California Open
Background Cancer is the leading cause of death among Latinos, the largest minority population in the United States (US). To address cancer challenges experienced by Latinos, we conducted a catchment area population assessment (CAPA) using…
View article: Implementation and evaluation of a multilevel intervention to increase uptake of the human papillomavirus vaccine among rural adolescents
Implementation and evaluation of a multilevel intervention to increase uptake of the human papillomavirus vaccine among rural adolescents Open
Purpose Geographic disparities exist in uptake of the human papillomavirus vaccine (HPV). In 2020, the National Immunization Survey‐Teen reported that adolescents living in nonmetropolitan statistical areas (MSAs) had lower HPV vaccination…
View article: Charting a Path Towards Asian American Cancer Health Equity: A Way Forward
Charting a Path Towards Asian American Cancer Health Equity: A Way Forward Open
On July 29, 2021, the US Food and Drug Administration’s Oncology Center of Excellence convened Conversations on Cancer. This Conversation, the first ever by the US Food and Drug Administration, focused on Asian Americans and served as the …
View article: Electronic Population Health Tools Enhance Preventive Care for Older Adults
Electronic Population Health Tools Enhance Preventive Care for Older Adults Open
View article: A Framework for Equitable Partnerships to Promote Cancer Prevention and Control in Rural Settings
A Framework for Equitable Partnerships to Promote Cancer Prevention and Control in Rural Settings Open
Rural populations continue to experience persistent cancer disparities compared with urban populations particularly in cancers that can be prevented or detected early through screening and vaccination. Although the National Cancer Institut…
View article: PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery
PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery Open
We created the PDX Network (PDXNet) Portal ( https://portal.pdxnetwork.org/ ) to centralize access to the National Cancer Institute-funded PDXNet consortium resources (i.e., PDX models, sequencing data, treatment response data, and bioinfo…
View article: Enhancing Electronic Health Systems to End Transmission of Chronic Hepatitis B During COVID‐19: A Collaborative Approach
Enhancing Electronic Health Systems to End Transmission of Chronic Hepatitis B During COVID‐19: A Collaborative Approach Open
The work described in this paper was funded in part by grant CPIMP191176 ("END B") from the Office of Minority Health, US Department of Health and Human Services and by grant A18‐2016‐001 from the Bristol‐Meyers Squibb Foundation, "UC Davi…
View article: Patient and clinician factors associated with uptake of the human papillomavirus (HPV) vaccine among adolescent patients of a primary care network
Patient and clinician factors associated with uptake of the human papillomavirus (HPV) vaccine among adolescent patients of a primary care network Open
View article: How a Priority of Community Outreach and Engagement Is Changing Health Equity at Cancer Centers
How a Priority of Community Outreach and Engagement Is Changing Health Equity at Cancer Centers Open
View article: Recommendations from a Dialogue on Evolving National Cancer Institute-Designated Comprehensive Cancer Center Community Outreach and Engagement Requirements: A Path Forward
Recommendations from a Dialogue on Evolving National Cancer Institute-Designated Comprehensive Cancer Center Community Outreach and Engagement Requirements: A Path Forward Open
While cancer mortality is declining in the United States, significant racial, ethnic, economic and geographic inequities persist. To help address inequities in cancer treatment, care, support and research, the National Cancer Institute (NC…
View article: Special Convening and Listening Session on Health Equity and Community Outreach and Engagement at National Cancer Institute-Designated Comprehensive Cancer Centers
Special Convening and Listening Session on Health Equity and Community Outreach and Engagement at National Cancer Institute-Designated Comprehensive Cancer Centers Open
In recent years, the cancer research and care community has been more attuned to health equity, increasingly pursuing coordinated and comprehensive action to achieve equitable health outcomes. In addition to its support of a joint research…
View article: Electronic health record alerts enhance mass screening for chronic hepatitis B
Electronic health record alerts enhance mass screening for chronic hepatitis B Open
To measure the effect of an electronic health record (EHR) alert on chronic hepatitis B (CHB) screening among at-risk Asian and Pacific Islanders (API). API patients who had not yet completed hepatitis B surface antigen (HBsAg) testing wer…
View article: The Emergence of a Sustainable Tobacco Treatment Program across the Cancer Care Continuum: A Systems Approach for Implementation at the University of California Davis Comprehensive Cancer Center
The Emergence of a Sustainable Tobacco Treatment Program across the Cancer Care Continuum: A Systems Approach for Implementation at the University of California Davis Comprehensive Cancer Center Open
Tobacco treatment is increasingly recognized as important to cancer care, but few cancer centers have implemented sustainable tobacco treatment programs. The University of California Davis Comprehensive Cancer Center (UCD CCC) was funded t…
View article: Screen to Save: Results from NCI's Colorectal Cancer Outreach and Screening Initiative to Promote Awareness and Knowledge of Colorectal Cancer in Racial/Ethnic and Rural Populations
Screen to Save: Results from NCI's Colorectal Cancer Outreach and Screening Initiative to Promote Awareness and Knowledge of Colorectal Cancer in Racial/Ethnic and Rural Populations Open
Background: The Center to Reduce Cancer Health Disparities (CRCHD), National Cancer Institute (NCI), launched Screen to Save, NCI's Colorectal Cancer Outreach and Screening Initiative to promote awareness and knowledge of colorectal cancer…
View article: “There’s Always Next Year”: Primary Care Team and Parent Perspectives on the Human Papillomavirus Vaccine
“There’s Always Next Year”: Primary Care Team and Parent Perspectives on the Human Papillomavirus Vaccine Open
Acceptance of the human papillomavirus (HPV) vaccination among parents and clinicians is high, but uptake remains low. Little is known about organizational and primary care team factors that influence the uptake of the HPV vaccine. Intervi…
View article: Operational strategies in US cancer centers of excellence that support the successful accrual of racial and ethnic minorities in clinical trials
Operational strategies in US cancer centers of excellence that support the successful accrual of racial and ethnic minorities in clinical trials Open
We have identified operational practices that facilitate increased inclusion of REMGs in cancer trials. In order to establish a sustainable cancer center inclusion research strategy, it is valuable to include an operational framework that …